[PDF] Top 20 Modeling mouse and human development using organoid cultures
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Modeling mouse and human development using organoid cultures
... pancreas development to be studied ex vivo, it does not support the long-term expansion of pancreas ...adult mouse pancreas cultures were established using similar culture conditions as those ... See full document
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Intersections of lung progenitor cells, lung disease and lung cancer
... in organoid co-culture studies have been transformative in providing functional assays for lung progenitor cell activity that allow analysis of cell–cell interactions in differentiation and ...from mouse ... See full document
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Derivation of a robust mouse mammary organoid system for studying tissue dynamics
... tissue development and disease (Clevers, ...This organoid system was subsequently adapted for other organs, including the liver, prostate and pancreas (Boj et ...1998). Development of mammary ... See full document
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The physics of organoids: a biophysical approach to understanding organogenesis
... organ development, including the exciting prospect of observing aspects of human embryo development ...silico modeling can complement the measurements performed in organoids to understand the ... See full document
6
Single-cell analysis reveals congruence between kidney organoids and human fetal kidney
... Thus, human kidney organoids contain stromal populations similar to hFK cortical stromal populations, which form part of the nephrogenic niche and have been shown to influence nephron formation in mice [46, ...and ... See full document
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The science and engineering of stem cell–derived organoids-examples from hepatic, biliary, and pancreatic tissues
... an organoid? Since self-organization within embryos has been analyzed using mathematical and physical laws, a key question is can organoid ...Mathematical modeling and simulations have been ... See full document
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Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infections
... 3D cultures more closely resemble in vivo con- ...neuronal cultures have been generated through hiPSC differentiation in scaffolds made of collagen [6], poly(lac- tic-co-glycolic acid)/poly( L -lactic acid) ... See full document
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Development of a human cardiac organoid injury model reveals innate regenerative potential
... to human heart tissue for basic biological studies, disease modeling, drug screening and regenerative medicine applications (Eder et ...differentiate human pluripotent stem cells (hPSC), such as ... See full document
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Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development
... of a homogeneous cellular identity is not occurring, in some cases (e.g., columns 10 to 12 and 19 to 21 in Fig. 2C and columns 1 to 9 in Fig. 5C), we are getting very close. Overall, our data support the concept that the ... See full document
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Brain organoids: advances, applications and challenges
... from using organoids to fully recapitulate late stages of human brain ...long-term organoid cultures ...Current organoid preparations also lack vascular cells and, although endothelial ... See full document
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Organoid single cell profiling identifies a transcriptional signature of glomerular disease
... diseased human glomerular tissues does not simply represent inclusion of healthy PECs in the glomerular tissue ...in human tissue and lineage tracing in a mouse FSGS model ...independent mouse ... See full document
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Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids
... the development of dis- ease pathology. Human cerebral organoids were generated from induced pluripotent stem cells (iPSCs) ...the cultures to develop glial populations, organoids were grown for 5 ... See full document
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Isolation and Propagation of Human Papillomavirus Type 16 in Human Xenografts Implanted in the Severe Combined Immunodeficiency Mouse
... neonatal human fore- skin prepared as before was incubated in 225 ml of the lysate for 1 h at ...repeated, using a different foreskin on six additional SCID ... See full document
6
Amyotrophic lateral sclerosis mutant TDP 43 may cause synaptic dysfunction through altered dendritic spine function
... genotyping. The top layer of the cortex was removed from single embryos and dissociated by 5 min enzymatic digestion at 37°C (0.025% w/v trypsin in 5 ml Hank ’ s Buffered Salt Solution; both Thermo Fisher Scientific), ... See full document
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Gene transfer vectors targeted to human prostate cancer : do we need better preclinical testing systems?
... The translation from cell lines in culture, and of rapidly growing xenografts of the same cell lines, to a heterogeneous and relatively slowly growing tumor in an immunocompetent patient is rarely considered in vector ... See full document
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Shan, Bing (2010): The novel sumoylation enhancer RSUME is implicated in pituitary tumor pathogenesis. Dissertation, LMU München: Fakultät für Biologie
... In contrast to studies in other types of solid tumors, it has been shown that pituitary adenomas appear less vascularized than non-tumorous anterior pituitary tissues (Jugenburg, et al. 1995; Schechter 1972; Turner, et ... See full document
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Murine Coronavirus Delays Expression of a Subset of Interferon-Stimulated Genes
... 293T cultures with MHV, however, was unable to inhibit SeV-induced translocation of IRF-3 ...(ChIP) using an IRF-3-specific antibody and assayed the precipitated chromatin fragments by qRT-PCR using ... See full document
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VEINCTR-N, an Immunogenic Epitope of Fas (CD95/Apo-I), and Soluble Fas Enhance T-cell Apoptosis in vitro. II. Functional Analysis and Possible Implications in HIV-1 Disease
... T-cell cultures from both patients and controls. T-cell cultures were started in plates at 1 10 6 /ml in RPMI-1640 plus 10% fetal calf serum, 10 g/ml PHA and interleukin-2 (IL-2), and maintained for up to ... See full document
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Tissue engineering laboratory models of the small intestine
... with intestinal stem cells, organoid units or human colonic adenocarcinoma cell lines.. such as Caco-2 and HT29-MTX to generate a number of in vitro and in vivo models.[r] ... See full document
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Metastatic tumor evolution and organoid modeling implicate TGFBR2as a cancer driver in diffuse gastric cancer
... The primary and metastatic tumor also shared biallelic splice donor site mutation (c.559 + 1G > A) of the fifth in- tron of TP53 and a chromosome 17p LOH event encom- passing the TP53 locus (Additional file 1: Figure ... See full document
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