[PDF] Top 20 Molecular function and regulation of the histone methyltransferase, Ezh2
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Molecular function and regulation of the histone methyltransferase, Ezh2
... relevant histone modifications (Mikkelsen et ...that EZH2 contributes to the repression of lncRNAs in ES cells as shRNA-mediated knockdown of EZH2 resulted in their ...novel function for ... See full document
179
Down regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells
... this methyltransferase in undifferentiated cells enhanced the subsequent induction of both PRL and IGFBP-1 transcripts in response to 8-Br-cAMP and MPA treatment ...upon EZH2 knockdown. To confirm that ... See full document
36
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
... of EZH2 repression in GC B ...This regulation was critical to repress Blimp1 and Irf4, since transcripts for both PC determinants were significantly upregulated in Ezh2 mutant GC B ...following ... See full document
15
Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2
... retain EZH2 activation. Unlike the MELK signaling mechanism, the regulation of EZH2 by NEK2 was at least partially dependent on the formation of a pro- tein complex that prolonged the half-life of ... See full document
16
Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo
... with EZH2. KDM2B depletion reduced the expression of EZH2 in ovarian cancer and suppressed the capability of cell proliferation and migration in ...in EZH2 epigenetic regulation in ovarian ... See full document
14
The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia
... of EZH2 expression and miR-101 in U-CLL, thus, corroborating our previous finding [15] that miR-101 is indeed implicated in the regulation of EZH2 ...other molecular mechanisms besides miR-101 ... See full document
14
Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
... epigenetic regulation and cross-talk between epigenetic regulators, the discovery of inhibitors of epigenetic processes that lead to reversal of epigenetic silencing may be more suited to cell-based methods meas- ... See full document
12
Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential
... highlighted EZH2 as a rational target for therapeutic intervention in sunitinib-resistant ...Modulating EZH2 expression or activity sup- pressed phosphorylation of certain RTK, restoring the anti-tumor ... See full document
10
Histone methyltransferase SUV39H2 regulates cell growth and chemosensitivity in glioma via regulation of hedgehog signaling
... the histone meth- yltransferases EZH2, which methylates H3K27, modifies the nonhistone protein by directly binding to STAT3 in ...by histone methylation needs to be fur- ther ... See full document
12
PubMedCentral-PMC5072726.pdf
... the histone methyltransferase activity of EZH2 is not required for the regulation of RelB transcription, yet tumorsphere number decreases when treated with inhibitors of EZH2 catalytic ... See full document
12
Fate determination in mesenchymal stem cells: a perspective from histone-modifying enzymes
... of EZH2 activates PIP5K1C and increases the intracellular Ca 2+ level via the PI3-kinase/Akt signaling pathway, which ultimately leads to the neuronal differentiation of MSCs both in vitro and in vivo ...[43]. ... See full document
9
EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer
... with EZH2 overexpression and increased H3K27me3 ...the histone methylation inhibitor 3-deazaneplanocin A (DZNep), recovery of CDKN1C expression was observed sug- gesting a direct link between H3K27me3 and ... See full document
7
Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens
... the regulation of multiple antiviral components and pathways by EZH2/1 inhibitors, it was hypothesized that these compounds would function as broad- spectrum antiviral ... See full document
14
Identification of SUV39H2 as a potential oncogene in lung adenocarcinoma
... transcriptional regulation of OPTN. However, the detailed molecular mechanism is still ...Moreover, histone demethylase LSD1 was found to be stabilized by SUV39H2 via methylation [45], which raised ... See full document
11
Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects
... [15], histone methylation/demethy- lation and acetylation/deacetylation [16, 17], microRNAs [18] and long non-coding RNAs [19, ...endothelial function [21], lineage commitment [22], and atherogenesis ... See full document
15
Conservation and function of the histone methyltransferase Set2
... H3K36 methyltransferase in vitro, but whether it functions as such in vivo has yet to be determined (Rayasam et ...H3K36 methyltransferase that interacts with elongating RNAPII (Sun et ...H3K36 ... See full document
179
Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells
... Low histone H3K27me3 levels in EZH2-KO cells during ...assess histone H3K27me3 levels in the viral promoters in EZH2-KO cells latently infected with EBV, we carried out ChIP assays followed by ... See full document
14
Thyroid hormone receptor actions on transcription in amphibia: The roles of histone modification and chromatin disruption
... organ function and during vertebrate ...the molecular mechanisms governing T3 action during vertebrate ...vivo. Molecular studies on amphibian metamorphosis have also revealed that developmental gene ... See full document
10
Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors
... HR alpha HPVs, and in particular HPV type 16 (HPV16), have been causally related to a subset of OPSCC arising from the crypt epithelium of the palatine tonsils and base of tongue [20, 21] as well as to a sub- stantial ... See full document
19
Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma
... mammalian histone methyltransferase which targets the H3K79 position ...transcriptional regulation, DNA damage response, cell cycle progression, somatic reprogramming and embryonic cell development ... See full document
10
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