[PDF] Top 20 Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex
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Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex
... the structural features of complexes purified from the ⌬ cagT mu- tant, we collected a data set of particles and generated class aver- ages (see ...T4SS core com- plexes, the 2D class averages of complexes ... See full document
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Microevolution of Helicobacter pylori Type IV Secretion Systems in an Ulcer Disease Patient over a Ten Year Period
... H. pylori by such microevolution of virulence-encoding genes are also not under- ...H. pylori J99 across 6 years ...croarray analysis revealed acquisition and deletion of several genes ...microarray ... See full document
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Structure of a bacterial type IV secretion core complex at subnanometre resolution
... example, Helicobacter pylori, the main causative agent of gastric ulcers and gastric adenocarcinoma, disrupts the homeostasis of the gastrointestinal tract via effectors secreted by the Cag T4S ... See full document
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CagY Dependent Regulation of Type IV Secretion in Helicobacter pylori Is Associated with Alterations in Integrin Binding
... elicobacter pylori infection most often causes only asymptomatic gastritis, but ...H. pylori is considered an important human pathogen because it is the major risk factor for development of peptic ulcer ... See full document
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Schindele, Franziska Maria (2017): Development and application of a novel Cag type IV secretion reporter assay in Helicobacter pylori. Dissertation, LMU München: Medizinische Fakultät
... general, Cag components can be discriminated into four factor classes [87]: secretion apparatus components (SA), translocation factors (TF), supportive components (SC) and accessory factors ...(AF). ... See full document
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Recent advances in the structural and molecular biology of type IV secretion systems
... the core/OM complex, six- fold symmetry for each IMC barrel, and two-fold sym- metry between the two IMC barrels), the stalk does not exhibit any evident ...T4S system, the stalk might form a ... See full document
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Jimenez Soto, Luisa Fernanda (2009): Studies on the function of the Cag Type IV Secretion System of Helicobacter pylori with integrin Beta1. Dissertation, LMU München: Medizinische Fakultät
... crystal structural studies, as well as EM negative staining studies, have revealed a bend/extended conformation change associated with the inactive/active form of the integrins (Arnaout et ...this molecular ... See full document
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Distinct Diversity of the cag Pathogenicity Island among Helicobacter pylori Strains in Japan
... Helicobacter pylori is a gram-negative microaerophilic bacte- rium that chronically colonizes the gastric epithelium of more than half of all people ...H. pylori and is highly ...of cag PAI ... See full document
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Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens
... utilize complex type IV secretion systems (T4SSs) to translocate diverse effector proteins or DNA into tar- get ...pathogens. Helicobacter pylori exploits a pilus appendage ... See full document
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Structural organisation of the type IV secretion systems
... which type IV secretion (T4S) systems form the most functionally ver- satile class ...of secretion systems from the ...as Helicobacter pylori, Brucella suis and Legionella ... See full document
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In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System
... ype IV secretion systems (T4SSs) are deployed by most species of bacteria for the conjugative transfer of mobile genetic elements (MGEs) to other bacteria and by many pathogenic species of bacteria for the ... See full document
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Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomes
... Background: Helicobacter pylori infection is associated with risk for chronic gastritis (CG), gastric ulcer (GU), duodenal ulcer (DU), and gastric cancer ...H. pylori Cag type IV ... See full document
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Type IV secretion of Helicobacter pylori CagA into oral epithelial cells is prevented by the absence of CEACAM receptor expression
... H. pylori strains Three different cell lines originating from oral epithelial cells, HN, CAL-27 and BHY, were infected with ...H. pylori and cell morphology was compared to an infected gastric epithelial ... See full document
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Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance
... bacterium Helicobacter pylori ( H. pylori ) causes chronic gastritis, gastric and duodenal ulcers, gastric cancer and mucosa-associated lymphoid tissue ...H. pylori infection are outlined in ... See full document
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Postreplication Roles of the Brucella VirB Type IV Secretion System Uncovered via Conditional Expression of the VirB11 ATPase
... Quantitation of virB gene expression. To measure expression of virB genes during infection, BMMs were seeded in 6-well plates and infected with wild-type B. abortus strain 2308 at a MOI of 200 (1, 4, 8, and 16 h ... See full document
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Twin Arginine Translocation System in Helicobacter pylori: TatC, but Not TatB, Is Essential for Viability
... H. pylori possesses only one AmiA protein (HP0772 in strain 26695 [21]), which shares 28% identity with ...AmiC. Analysis of the protein sequence of H. pylori AmiA (HpAmiA) reveals the presence of a ... See full document
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Structural and functional characterization of the <em>Helicobacter pylori </em>cytidine 5'-monophosphate-pseudaminic acid synthase PseF: molecular insight into substrate recognition and catalysis mechanism
... Analysis of PPI networks is necessary for better understand- ing of intricate molecular mechanisms and identification of novel therapeutics to combat multidrug-resistant bacteria. Figure 12 shows PPI ... See full document
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Helicobacter pylori down regulates expression of human ß defensin 1 in the gastric mucosa in a type IV secretion dependent fashion
... H. pylori usurps NF- κ B signalling to downregulate h β D1 We next aimed to determine the intracellular signalling pathways through which ...H. pylori regulates h β D1 expres- sion. Sequence analysis ... See full document
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Membrane and Core Periplasmic Agrobacterium tumefaciens Virulence Type IV Secretion System Components Localize to Multiple Sites around the Bacterial Perimeter during Lateral Attachment to Plant Cells
... Immunofluorescence microscopy. vir-induced cells were fixed in 2.67% paraformaldehyde and 0.01% gluteraldehyde for 15 minutes at room temperature. Cells were washed once in GTE (50 mM glucose, 25 mM Tris, pH 8, 10 mM ... See full document
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Pediatric Helicobacter pylori Isolates Display Distinct Gene Coding Capacities and Virulence Gene Marker Profiles
... Helicobacter pylori strains display remarkable genetic diversity, and the presence of strains bearing the toxigenic vacA s1 allele, a complete cag pathogenicity island (PAI), cagA alleles containing ... See full document
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