[PDF] Top 20 Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
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Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
... the human immunodeficiency virus type 1 (HIV-1) genome into a chromosome of an infected cell is a pivotal step in virus ...the virus-encoded integrase, which ... See full document
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Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues.
... The role of these residues in IN function has been investigated in vitro, using deletion and substitution mutants of IN protein from human immunodeficiency virus type 1 HIV-1 11, 14, 30,[r] ... See full document
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Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection.
... The viral integrase (IN) protein is the only viral protein known to be required for integration of the human immunodeficiency virus type 1 (HIV-1) genome ... See full document
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Role of Human Immunodeficiency Virus Type 1 Integrase in Uncoating of the Viral Core
... the viral life cycle, including re- verse transcription, nuclear import of the PIC, and integration of the viral cDNA into the host genome ...during viral replication ...tain mutations ... See full document
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Posttranslational Acetylation of the Human Immunodeficiency Virus Type 1 Integrase Carboxyl-Terminal Domain Is Dispensable for Viral Replication
... in integrase (3). The mutations were introduced by overlap PCR and the entire recombined fragment confirmed by DNA sequence ...pro- viral clone with a genetic pedigree convergent with that of R7/3 ... See full document
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Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells.
... of integrase necessary for replication-competent ...a replication-competent mutant or is not conservatively substi- tuted in other HIV-1 ...for viral replication, a panel of 14 ... See full document
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Effects of Random Mutations in the Human Immunodeficiency Virus Type 1 Transcriptional Promoter on Viral Fitness in Different Host Cell Environments
... ⫺ 1 is subsequently inherited in both LTRs of the viral progeny after the first round of virus ...extra mutations in the genome which may influence the obtained fitness measurements we took ... See full document
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Human Immunodeficiency Virus Type 1 Envelope-Mediated Neuronal Death: Uncoupling of Viral Replication and Neurotoxicity
... with human immunodeficiency virus (HIV) and/or AIDS is consistently infected by HIV type 1 (HIV-1), only 20 to 30% of patients exhibit clinical or neuropathological evidence of ... See full document
14
Targeting Human Immunodeficiency Virus (HIV) Type 2 Integrase Protein into HIV Type 1
... other viral and cellular proteins that make up the viral nucleo- protein complex ...the virus life cycle. Host cell proteins that bind to IN or the HIV-1 preintegration complex (PIC) and ... See full document
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Irreversible Inhibition of Human Immunodeficiency Virus Type 1 Integrase by Dicaffeoylquinic Acids
... as integrase inhibitors by using the biochemical assay and purified recombinant integrase, though structurally belonging to different chemical classes, contain one or more hydroxyl substituents (6, 13, 14, ... See full document
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Lys-34, Dispensable for Integrase Catalysis, Is Required for Preintegration Complex Function and Human Immunodeficiency Virus Type 1 Replication
... wild-type virus at 7 hpi ...wild type at 7 hpi ...mutant viral reverse transcription remained low at 24 hpi, we concluded that the reductions observed at 7 hpi were due to overall impairment ... See full document
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Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations.
... Making the entire viral DNA portion single-stranded further reduced the disintegration activity approximately twofold observed with the wild type and mutants ING47L, DISCUSSION We expres[r] ... See full document
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Compensatory Point Mutations in the Human Immunodeficiency Virus Type 1 Gag Region That Are Distal from Deletion Mutations in the Dimerization Initiation Site Can Restore Viral Replication
... the viral protease during the processing of Gag precursor proteins (18, ...with virus assembly and to result in fewer infectious particles, and more aberrant morphology, in spite of the presence of the ... See full document
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Monoclonal antibodies against human immunodeficiency virus type 1 integrase: epitope mapping and differential effects on integrase activities in vitro.
... the viral DNA ends but is dispensable for binding of the branched disintegration sub- strate, binding of MAbs to this region would lead to the ob- served complete inhibition of end processing, integration, and ... See full document
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Formation of a Human Immunodeficiency Virus Type 1 Core of Optimal Stability Is Crucial for Viral Replication
... study were previously found to be competent for particle as- sembly, to exhibit normal processing of Gag, and to incorpo- rate envelope protein (Env) at levels similar to those for wild- type HIV-1 (von ... See full document
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HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers
... that virus-specific cy- totoxic T lymphocytes (CTLs) play a crucial role in controlling AIDS virus replication (1, 17, 18, 20, ...plasma viral loads and better clinical out- comes (14, ... See full document
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Effects of Mutations in the Human Immunodeficiency Virus Type 1 gag Gene on RNA Packaging and Recombination
... infectious virus, and these mutant RNAs cannot efficiently compete with wild-type viral RNA for ...the viral RNA, even in the presence of competing wild-type ... See full document
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Quantification of the Effects on Viral DNA Synthesis of Reverse Transcriptase Mutations Conferring Human Immunodeficiency Virus Type 1 Resistance to Nucleoside Analogues
... Human immunodeficiency virus type I (HIV-1) reverse transcriptase (RT) resistance mutations reduce the susceptibility of the virus to nucleoside analogues but may also ... See full document
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Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.
... coma virus forms a similar dimer ...two viral ends 5 bp (approximately 17 Å) apart ...is replication defective due to a block in integration ... See full document
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Oligomerization within Virions and Subcellular Localization of Human Immunodeficiency Virus Type 1 Integrase
... carrying mutations or dele- tions in separate functional domains (20, 21, 27, ...during virus replication because of the lack of a sensitive detection ... See full document
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