[PDF] Top 20 Mutations within the 5' nontranslated region of hepatitis A virus RNA which enhance replication in BS-C-1 cells.
Has 10000 "Mutations within the 5' nontranslated region of hepatitis A virus RNA which enhance replication in BS-C-1 cells." found on our website. Below are the top 20 most common "Mutations within the 5' nontranslated region of hepatitis A virus RNA which enhance replication in BS-C-1 cells.".
Mutations within the 5' nontranslated region of hepatitis A virus RNA which enhance replication in BS-C-1 cells.
... Analysis of the growth properties of viruses rescued from these chimeras indicates that mutations at bases 152 and/or 203 to 207 of the 5'NTR strongly enhance replication competence in c[r] ... See full document
8
Role of the 5′-Proximal Stem-Loop Structure of the 5′ Untranslated Region in Replication and Translation of Hepatitis C Virus RNA
... positive-strand RNA viruses, the 5⬘UTR has multiple important roles in the regulation of viral RNA trans- lation and/or replication (3, 4, 10, 18, 19, 22, 45, ...the 5⬘ end of the viral ... See full document
7
Small Interfering RNA Targeted to Hepatitis C Virus 5′ Nontranslated Region Exerts Potent Antiviral Effect
... Hepatitis C virus (HCV) is a major cause of cirrhosis and hepatocellular ...hairpin RNA (shRNA) targeting the 5 ⴕ nontranslated conserved region of the HCV genome for ... See full document
8
Mutations in the 5′ Trailer Region of a Respiratory Syncytial Virus Minigenome Which Limit RNA Replication to One Step
... of which was likely ...trailer mutations on the production of progeny ...genomic RNA is encapsidated properly, the genomic promoter at its 3⬘ end (Fig. 1, step 3) should be fully functional, ... See full document
10
Effects of Defined Mutations in the 5′ Nontranslated Region of Rubella Virus Genomic RNA on Virus Viability and Macromolecule Synthesis
... Rubella virus (RUB) is the sole member of the Rubivirus genus of the Togaviridae family of animal ...genomic RNA of approximately 10,000 nucleotides (nt) and multiple copies of a single capsid protein ... See full document
10
Enhancement of Hepatitis C Virus RNA Replication by Cell Culture-Adaptive Mutations
... adaptive mutations in the HCV coding sequence. Since adaptive mutations should be generated early during selection and become fixed in all RNA progeny, we focused our further analyses on the ... See full document
11
Viral RNA Mutations Are Region Specific and Increased by Ribavirin in a Full-Length Hepatitis C Virus Replication System
... error-prone replication, RNA viruses must also maintain highly conserved genomic ...other RNA viruses. We therefore used a novel hepatitis C virus (HCV) replication system ... See full document
13
Sequences in the 5′ Nontranslated Region of Hepatitis C Virus Required for RNA Replication
... the 5⬘ NTR are not required for IRES ...the 5⬘ end of a viral RNA genome are very important determinants for replication, we anticipated that the same might be true for ...The region ... See full document
11
Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production
... JFH-1 virus induced only transient and mild infection, even though JFH-1 was isolated from a patient with fulminant hepatitis ...culture-adaptive mutations has also been reported for ... See full document
16
Large deletion mutations involving the first pyrimidine-rich tract of the 5' nontranslated RNA of human hepatitis A virus define two adjacent domains associated with distinct replication phenotypes.
... Parallel titrations of A131-144 virus in BS-C-1 cells at 31 and 37°C demonstrated a difference of 1.8 log10 rfu/ml in the titer of the working virus stock determined in radioimmunofocus [r] ... See full document
11
Analysis of Mutations within the 5′ Untranslated Region, Interferon Sensitivity Region, and PePHD Region as a Function of Response to Interferon Therapy in Hepatitis C Virus Infected Patients in India
... ment, which resulted in a change in its genotype from type 3b to type ...the mutations in the 5 ⬘ UTR might have facilitated replication of the virus in the infected ...these ... See full document
7
A Hepatitis C Virus NS5A Phosphorylation Site That Regulates RNA Replication
... infectious virus production and as this may be linked to phos- phorylation, we harvested supernatants of cells 48 h after the de- livery of our mutant RNAs and determined the titers of the amount of ... See full document
6
Replication of a hepatitis C virus replicon clone in mouse cells
... adaptive mutations has recently led to the development of in vitro HCV infection models in Huh-7 cells [5-7] and the demonstration that full length HCV replicons are capable of producing infec- tious ... See full document
9
Mutations within the 5' nontranslated RNA of cell culture-adapted hepatitis A virus which enhance cap-independent translation in cultured African green monkey kidney cells.
... desirable replication properties in ...kidney cells. One virus, HM175/P16, which replicates very poorly in primates compared with HM175/wt, contains 19 mutations from the wild-type ... See full document
9
3′ Nontranslated RNA Signals Required for Replication of Hepatitis C Virus RNA
... restore replication competence ...restore replication competence to the RNA, although the level of SEAP expres- sion (and thus the imputed abundance of viral RNA) was less than 10% of that ... See full document
12
Genetic Analysis of Sequences in the 3′ Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication
... the 5⬘-proximal part of the variable region introduced into an infectious genome is viable in vivo ...of RNA replication and whether the full complement of the vari- able region is ... See full document
13
Mutations in the 5′ Nontranslated Region of Bovine Viral Diarrhea Virus Result in Altered Growth Characteristics
... positive-strand RNA viruses are thought to contain signals important for translation, transcription, repli- cation, and probably also packaging of viral genomes (7–10, 22, 25, 27, ...element which is ... See full document
11
Hepatitis C Virus RNA Replication Requires a Conserved Structural Motif within the Transmembrane Domain of the NS5B RNA-Dependent RNA Polymerase
... in which the HCV NS5B TMD was replaced by the corresponding newly identified segment from GBV-B ...brane, which is conceivable given the length of the lysine side chain that allows the charge to reach the ... See full document
5
Hypervariable Region 1 Sequence Stability during Hepatitis C Virus Replication in Chimpanzees
... swarm of distinct but related variants. The number of variants (complexity) was similar to that found in acute human HCV infection. In each animal there was a master (most commonly observed) sequence representing 24 to ... See full document
9
Virion-Independent Transfer of Replication-Competent Hepatitis C Virus RNA between Permissive Cells
... HCV RNA transfer, and exosomes concen- trated from SGR cells were not able to transmit HCV RNA to target cells directly (data not ...HCV RNA from SGR cells to plasmacytoid ... See full document
6
Related subjects