[PDF] Top 20 Mutations in the Primer Grip of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impair Proviral DNA Synthesis and Virion Maturation
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Mutations in the Primer Grip of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impair Proviral DNA Synthesis and Virion Maturation
... alternative primer pairs for determination of early and late steps of reverse ...each primer pair relative to the viral genome is schematically represented on the left of each ...The primer ... See full document
5
Mutations in the U5 Region Adjacent to the Primer Binding Site Affect tRNA Cleavage by Human Immunodeficiency Virus Type 1 Reverse Transcriptase In Vivo
... tRNA primer (Fig. 1) (2, ...RT-RNA DNA complex and 17 bp apart for an HIV-1 RT-DNA DNA complex; this is in good agreement with where RNase H cleaves model substrates in vitro (9, ... See full document
9
Hypersusceptibility to Substrate Analogs Conferred by Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... double-stranded DNA by re- verse transcriptase (RT) is a defining step in the retroviral life cycle (8) and a key target of therapy for human immunodefi- ciency virus type 1 ... See full document
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Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication.
... template DNA were ...9 primer containing an NcoI site (under- lined, which introduced a translation initiation codon), 5 9 -TGCCATGGCCATT AGCCCTATTG AGACTGT-39, and a 39 primer containing a HindIII ... See full document
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Expression of human immunodeficiency virus type 1 reverse transcriptase in trans during virion release and after infection.
... the virion as a component of the Gag-Pol polyprotein. In the maturation of the Gag-Pol polyprotein of human immunodeficiency virus type 1 (HIV-1), cleavage by the ... See full document
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Mutations Proximal to the Minor Groove-Binding Track of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Differentially Affect Utilization of RNA versus DNA as Template
... on DNA templates ...length DNA similar to the wild type when the rebinding of RT is allowed (nonprocessive ...template- primer affinity on a DNA but not RNA ...most mutations in ... See full document
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Quantification of the Effects on Viral DNA Synthesis of Reverse Transcriptase Mutations Conferring Human Immunodeficiency Virus Type 1 Resistance to Nucleoside Analogues
... of reverse transcription following infection of target ...resistance mutations on reverse transcription by HIV-1, we developed techniques permitting the quantification of reverse ... See full document
11
Mutations in the RNase H Primer Grip Domain of Murine Leukemia Virus Reverse Transcriptase Decrease Efficiency and Accuracy of Plus-Strand DNA Transfer
... H primer grip of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) contacts the DNA primer strand and positions the ... See full document
9
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis.
... of virus particle formation, as the infectivity of D Nef virus could be enhanced by providing the protein in virus producer but not target ...of reverse transcription after they were ...viral ... See full document
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Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesis.
... tained for 2 weeks in exponential growth and verified every 2 or 3 days for the appearance of cytopathic effects (CPE). The viral titer was defined as the last infectious dilution as determined by the presence of CPE and ... See full document
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Frequency of Mutations Conferring Resistance to Nucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus Type 1 Infected Patients in Korea
... having mutations at RT codon amino acid positions 41, 67, 70, 210, 215, and 219 (5, 10, 14, 15, ...resistance mutations in antiretroviral therapy-naive patients (24) have already been reported, there has ... See full document
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Immunogenicity of Mutations Induced by Nucleoside Reverse Transcriptase Inhibitors for Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Cells
... conclusion, mutations induced by NRTI do not cause loss of CTL recognition of the RT regions harboring the ...these mutations over time might reflect not an im- mune escape by lack of recognition but rather ... See full document
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The Impact of Multidideoxynucleoside Resistance-Conferring Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Polymerase Fidelity and Error Specificity
... of mutations by wild-type and multidrug-resistant HIV-1 ...of mutations generated during the gap fill-in DNA synthesis reaction, M13 templates from 117 plaques representing the ... See full document
6
Minority Human Immunodeficiency Virus Type 1 Variants in Antiretroviral-Naive Persons with Reverse Transcriptase Codon 215 Revertant Mutations
... NNRTI-associated mutations such as K103N have been shown to be strong predictors of virologic failure in persons receiving an NNRTI-containing regimen (1, 12), transmitted T215 revertants have had a less ... See full document
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Effects of Dipeptide Insertions between Codons 69 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Primer Unblocking, Deoxynucleoside Triphosphate Inhibition, and DNA Chain Elongation
... Human immunodeficiency virus type 1 (HIV-1) reverse tran- scriptase (RT) is responsible for replication of the HIV-1 ge- nome and is therefore an important target ... See full document
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Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
... 4887 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Human immunodeficiency virus type 1 HIV-1-specific pyridinone reverse transcriptase RT inhibitors prevent HIV-1 rep[r] ... See full document
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The K65R Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Exhibits Bidirectional Phenotypic Antagonism with Thymidine Analog Mutations
... acids 1 to 560) of RT by RT-PCR, purifying the PCR product (Wizard PCR Purification System; Promega, Madison, ...automated DNA sequencer (Applied Biosystems, Foster City, ...no-drug, virus-infected ... See full document
7
Equine infectious anemia virus and human immunodeficiency virus DNA synthesis in vitro: characterization of the endogenous reverse transcriptase reaction.
... 1952 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The endogenous reverse transcriptase reaction of equine infectious anemia virus EIAV has been studied, and conditio[r] ... See full document
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A Mutation in the 3′ Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Y318F) Associated with Nonnucleoside Reverse Transcriptase Inhibitor Resistance
... resistance mutations commonly associated with NNRTI resistance in a large panel of HIV-infected, antiretroviral drug-treated Canadian patients (n ⫽ ...7611). Mutations presented include the following: ... See full document
5
Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase.
... not, by themselves, appear to be important in determining the sensitivity of HIV-1 RT to TBA, HEPT, or calanolide A, it is still possible that these substitutions could have an effect if[r] ... See full document
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