[PDF] Top 20 Nonstructural Protein 5A of Hepatitis C Virus Inhibits the Function of Karyopherin β3
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Nonstructural Protein 5A of Hepatitis C Virus Inhibits the Function of Karyopherin β3
... pYAD- 5A(1973-2419), which contains the GAL4 AD and the full-length HCV NS5A protein, was constructed by inserting the DNA insert of pYBD-5A(1973-2419) excised with XmaI into the XmaI site of ...NS5A ... See full document
9
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling
... AMPK reportedly plays a pivotal role in many cellular signaling cascades [36–39]. To this end, we investigated whether NS5A mediates the AMPK/SREBP-1c pathway to disrupt lipid homeostasis. Hepa1–6 and HepG2 cells were ... See full document
13
Inhibition of Intrahepatic Gamma Interferon Production by Hepatitis C Virus Nonstructural Protein 5A in Transgenic Mice
... ␥ inhibits extracellular matrix mRNA expression ...self-limited hepatitis C display the strongest virus-specific CD4 ⫹ T-cell (IFN- ␥ ) reactivity while persistently infected sub- jects ... See full document
7
Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing.
... HCV nonstructural protein ...HCV nonstructural protein processing, a viral serine proteinase (Cpro-2)-dependent trans cleavage assay was ...The function of NS4A in the processing of HCV ... See full document
7
Conserved Determinants for Membrane Association of Nonstructural Protein 5A from Hepatitis C Virus and Related Viruses
... The observation that very similar membrane anchor do- mains with highly ordered structures can be found in these related viruses strongly supports the hypothesis that these pro- tein domains share a common ... See full document
13
A Conserved Tandem Cyclophilin-Binding Site in Hepatitis C Virus Nonstructural Protein 5A Regulates Alisporivir Susceptibility
... NS5A function that depends upon isomerization is not clear, partly because the precise roles that NS5A plays in HCV replication and virion assembly (1, 52) are not fully ...The C-terminal half of NS5A that ... See full document
12
Regulation of mRNA Translation and Cellular Signaling by Hepatitis C Virus Nonstructural Protein NS5A
... Mnk1 protein kinase, which in turn phosphorylates the translation initiation factor eIF4E (48, ...viral protein synthesis by NS5A ...of protein synthesis late after infection was simply due to the ... See full document
9
Hepatitis C Virus Nonstructural Protein 5A: Biochemical Characterization of a Novel Structural Class of RNA-Binding Proteins
... the protein did not cross-link to the RNA, consistent with the cross-linking being mediated by interactions other than ionic interactions of a non- specific nature ...to function in RNA binding, the RNA ... See full document
12
Hepatitis C Virus Nonstructural 5A Protein and Interferon Resistance: a New Model for Testing the Reliability of Mutational Analyses
... Therefore, in a next step, analyses in other regions of the NS5A protein were performed based on 70 full-length NS5A sequences (31). Screening multiple regions of the complete NS5A by pointwise significance levels ... See full document
12
Gene Expression Profiling of the Cellular Transcriptional Network Regulated by Alpha/Beta Interferon and Its Partial Attenuation by the Hepatitis C Virus Nonstructural 5A Protein
... An HCV subgenomic replicon has little effect on ISG expres- sion. Given that NS5A was capable of down-regulating a sub- set of ISGs, we were interested in determining whether the same phenomenon occurred in Huh7 cells ... See full document
9
Mutational Analysis of Hepatitis C Virus Nonstructural Protein 5A: Potential Role of Differential Phosphorylation in RNA Replication and Identification of a Genetically Flexible Domain
... poly- protein processing but rather to disturbance of NS5A ...fusion protein that displayed an endoplasmic reticulum (ER)-like subcellular distribution ...the C terminus of NS5A is genetically highly ... See full document
8
Virus-Specific Cofactor Requirement and Chimeric Hepatitis C Virus/GB Virus B Nonstructural Protein 3
... GB virus B (GBV-B) is closely related to hepatitis C virus (HCV) and causes acute hepatitis in tamarins (Saguinus species), making it an attractive surrogate virus for in vivo ... See full document
11
Role for TBC1D20 and Rab1 in Hepatitis C Virus Replication via Interaction with Lipid Droplet-Bound Nonstructural Protein 5A
... with hepatitis C vi- rus ...chronic hepatitis, which may progress to life-threatening liver cirrhosis and hepatocellular carcinoma ...RNA virus containing a ...as nonstructural (NS) ... See full document
12
Interferon Resistance of Hepatitis C Virus Genotype 1b: Relationship to Nonstructural 5A Gene Quasispecies Mutations
... the nonstructural 5A (NS5A) protein of hepatitis C virus genotype 1b (HCV-1b) was recently suggested to be the interferon sensitivity-determining region (ISDR), because HCV-1b ... See full document
11
The NTPase/helicase domain of hepatitis C virus nonstructural protein 3 inhibits protein kinase C independently of its NTPase activity
... Chronic hepatitis C virus (HCV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC) ...of protein kinase C (PKC) [3, 4] and it interacts with the ... See full document
12
Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response
... NS5A protein has been controversially implicated in inhibition of the IFN system in clinical and in vitro studies, the following experiments were performed to investigate other po- tential mechanisms of IFN ... See full document
12
Characterization of a Threonine-Rich Cluster in Hepatitis C Virus Nonstructural Protein 5A and Its Contribution to Hyperphosphorylation
... weight of NS5A toward p58, which can be achieved by a limited number of mutations at various sites in LCS-I. However, these negative charges seem not to act as priming phosphorylation sites, as suggested previously (25, ... See full document
24
Sequential S232/S235/S238 Phosphorylation of the Hepatitis C Virus Nonstructural Protein 5A
... protease function is required for NS5A hyper- phosphorylation ...S229. Protein kinases, including polo-like kinase 1 (38), calmodulin-dependent kinase II (35), and GSK3  (22) reported to affect NS5A ... See full document
14
Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry
... employing protein array screening, we identified Pim1 as the HCV NS5A ...either function in a cooperative manner or act redundantly in HCV propagation, and thus, functional inacti- vation of Pim1 could be ... See full document
14
Efficient Rescue of Hepatitis C Virus RNA Replication by trans-Complementation with Nonstructural Protein 5A
... a function out- side the ...indirect function of NS5A that enhances host cell permissiveness and/or RNA replication in general is less ...NS5A protein into the altered ... See full document
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