[PDF] Top 20 Notch signaling in the development of the inner ear
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Notch signaling in the development of the inner ear
... and ear sensory patches that we have summarized above add up to a persuasive argument that these mechanosensory organs are indeed homologous—that they resemble one another because they have evolved from a common ... See full document
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Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development
... mammalian inner ear is a sensory organ with dual roles in sound and motion ...the inner ear to auditory and vestibular components occurs early in embryonic development, allowing each of ... See full document
10
Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair cell differentiation
... of development of the chick inner ear and its sensory ...The inner ear of a bird originates by invagination of the otic placode and remodelling of the resulting otic vesicle to form the ... See full document
11
From placode to polarization: new tunes in inner ear development
... in inner ear ...the ear forms, it is also important to recognize that these discoveries may contribute to our understanding of, and potential treatments for, human ... See full document
12
Pocket proteins and cell cycle regulation in inner ear development
... the development of appropriate alternatives for the new proliferation of lost sensory ...the inner ear results in massive proliferation of HCs and to some extent SCs, followed by massive apoptotic ... See full document
12
Limited inner ear morphogenesis and neurosensory development are possible in the absence of GATA3
... for inner ear neurosensory development as well as morphogen- esis beyond those previously described (Lillevali et ...tiating inner ear afferent neurons (Jahan et ...the ear and ... See full document
8
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
... The Notch signaling pathway plays myriad roles in both developing and adult multicellular organisms (for reviews, see Baron, 2003; Gridley, 2003; Lai, 2004; Schweisguth, ...the inner ear, in ... See full document
10
Grhl1 deficiency affects inner ear development in zebrafish
... cochlear development have also been ...exhibited inner ear developmental malformations, including missing otoliths, disordered and abnormal numbers of hair cells in the inner ear and ... See full document
8
Analysis of Netrin 1 receptors during inner ear development
... Ntn1-/- inner ear development and the adhesion mediating Ntn1 receptors, Neo1 (Srinivasan et ...on inner ear ...in inner ear remains to be ...in inner ear ... See full document
7
Ligand dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear
... differential signaling strength and competition between Jag1 and Dl1 for Notch is crucial for orchestrating lateral induction and lateral inhibition during ear ...Jag1, Notch establishes a ... See full document
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Notch signaling in vascular development and physiology
... the Notch pathway in regulating vascular development, protein components of the Notch pathway might provide novel drug targets during tumor ...Dll4/Notch signaling, inhibit the growth ... See full document
10
Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway
... conserved Notch signaling pathway mediates cell-to-cell communication to regulate cell fate decisions and patterning in both invertebrates and ...system Notch signaling was classically ... See full document
11
Postembryonic neuronal addition in Zebrafish dorsal root ganglia is regulated by Notch signaling
... this signaling pathway functions in a context-dependent manner. Notch signaling plays a role in the establishment of neural crest [17,22,47], and in the de- velopment of neural crest-derived ... See full document
13
Axon guidance in the inner ear
... the inner ear sensory organs where they will ultimately become post-synaptic to mature hair ...early ear development, neuroblasts delaminate from a restricted region of the ventral otocyst and ... See full document
9
Single cell analysis of the inner ear sensory organs
... The issue of asynchronicity of the genetic plan and transcrip- tomes of similar cellular states became more relevant in the age of multi-parallel qRT-PCR and scRNA-Seq, as the amount of data and resolution increased. ... See full document
10
Establishment of a proneural field in the inner ear
... many genes implicated in the process of neurosensory develop- ment have been identified both in invertebrates and vertebrates (Ghysen and Richelle, 1979, Torres and Giraldez, 1998, Baker and Bronner-Fraser, 2001). Now it ... See full document
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Role of Notch signaling in cell fate determination of human mammary stem/progenitor cells
... upon Notch activation is consist- ent with previous studies demonstrating that proliferation of myoepithelial cells can facilitate branching ...Moreover, Notch signaling appears to be absolutely ... See full document
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Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate
... oligodendrocyte development we found one allele, vu56, that caused forma- tion of excess OPCs in numbers similar to that produced by NICD ...including Notch, for ...that Notch signaling is the ... See full document
12
Axial patterning in the developing vertebrate inner ear
... the development of any asymmetric organ is whether there is initially a symmetric stage on which pattern is imposed by a later symmetry-breaking ...presumptive ear ectoderm in amphibian (sala- mander) ... See full document
14
Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear
... vertebrate inner ear is composed of interconnected fluid-filled cavities, which are lined with an epithelium containing several distinct patches of sensory hair cells, responsible for the perception of ... See full document
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