[PDF] Top 20 Novel statistical methods for the study design and analysis of genome-wide association studies
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Novel statistical methods for the study design and analysis of genome-wide association studies
... combined study. We have focused our calculations primarily on a study design for a GWA study based on 500,000 ...two-stage design can sig- nificantly increase power for smaller ... See full document
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GENOME-WIDE ASSOCIATION STUDIES IN PHARMACOGENOMICS
... GWAS design to date has been the case-control study design in which genotype frequencies in patients with the disease of interest are compared to those in a disease-free group ...appropriate ... See full document
9
Gene based bin analysis of genome wide association studies
... and design and (ii) to identify genes potentially associated to Multiple ...lection design outperforms the one-study design in terms of expected number of true-positives, despite differences ... See full document
9
Application of imputation methods to the analysis of rheumatoid arthritis data in genome wide association studies
... genetic association studies only genotype a small proportion of cataloged single-nucleotide polymorphisms (SNPs) in regions of ...in association studies. Several imputation methods and ... See full document
5
Multivariate methods and software for association mapping in dose‐response genome‐wide association studies
... summary methods (such as estimating the IC50 for each DR curve and treating this estimate as the response), MANOVA makes no assumption about the nature of the DR curve or about what the differences in the DR ... See full document
15
Selection of important variables by statistical learning in genome wide association analysis
... (BNT) analysis seems capable of capturing biologically mean- ingful interactions among a group of factors involved in a complex manner in common diseases ...Genetic Analysis Workshop (GAW) 16 Problem 3 ... See full document
5
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip
... Our study has certain ...standardisation methods should substan- tially improve the power of GWAS to identify novel fi ndings in the near ...expression study is that there are few individuals ... See full document
7
Comparison of methods for correcting population stratification in a genome wide association study of rheumatoid arthritis: principal component analysis versus multidimensional scaling
... RA studies [8-11]. The total number of SNPs that reached genome-wide significance (p-value < ...the analysis using the trend test, 221 for the analysis adjusted for the significant ... See full document
6
NME8 rs2718058 polymorphism with Alzheimer’s disease risk: a replication and meta-analysis
... five genome wide association studies (GWAS) has identified that a novel single nucleotide polymorphism (SNP) rs2718058, adjacent to gene NME8 on chromosome ...and statistical ... See full document
7
Family based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families
... tion studies are sometimes more powerful than linkage ...large genome-wide association studies (GWAS) instead of family-based methods where sample sizes are more ...GWAS ... See full document
10
Genome wide association studies using an adaptive two stage analysis for a case control design
... for genome- wide association studies with optimal choice of signifi- cance level to maximize the power and at the same time asymptotically control the overall type I ...ATS analysis ... See full document
5
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
... present study and to identify more genome-wide signi fi cant fi ...From studies of other polygenic complex traits, it has been observed that the number of discovered variants is strongly ... See full document
10
Genome wide association study for multiple phenotype analysis
... a genome-wide scale. Research studies often collect data on multiple related phenotypes to bet- ter understand disease structure; however, genome-wide association studies ... See full document
6
Radiogenomics Consortium Genome-Wide Association Study Meta-analysis of Late Toxicity after Prostate Cancer Radiotherapy.
... our study is the prospective longitudinal assessment of toxicity enabling use of time-to-event analysis to maximize information across multiple toxicity ...radiogenomic studies, and future work ... See full document
41
On Considering Epistasis in genome Wide Association Studies.
... Larger studies are needed in which candidate gene polymorphisms and associated cytokine pathways are fully evaluated in all patients, so that any genetic polymorphisms identified can be interpreted in the context ... See full document
205
Statistical analysis of haplotypes, untyped SNPs, and CNVs in genome-wide association studies
... Recent studies implicated that common SNPs and rare, large CNVs are associated with schizophrenia, but the joint effects of CNVs and SNPs have not been ...our methods for integrated analysis of CNVs ... See full document
147
Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant
... as association remains significant after adjustment for age, gender, and BMI using the logistic regression ...Chinese study of replication 2, when we set the significance threshold to P < ...the ... See full document
10
Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
... action analysis between the tagging SNPs of the two genes was conducted using the epistasis option in PLINK to assess potential gene-gene ...previous studies for interaction ...interaction analysis ... See full document
7
DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns
... richment Analysis (GSEA) [18] based on the canon- ical pathway’s curated gene sets (CP , 1329 gene sets in the ...over-representation analysis is a statistical test based on hypergeometric ... See full document
8
Genome-wide association analysis of body conformation traits in Mexican Holstein cattle using a mix of sampled and imputed SNP genotypes.
... results, association analysis was performed using two different ...an association with quadratic regression; ...Next, association analysis was performed using Generalized Linear models, ... See full document
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