[PDF] Top 20 Original Article The identification of the key genes and pathways in septic shock using an integrated bioinformatics analysis
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Original Article The identification of the key genes and pathways in septic shock using an integrated bioinformatics analysis
... units. Septic shock is a severe, dan- gerous type of sepsis; however, the molecular mechanisms involved in septic shock are largely ...study integrated three datasets with 210 ... See full document
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Original Article Identification of candidate genes and pathways in cisplatin-resistant NSCLC by integrated bioinformatics analysis
... expressed genes (DEGs), which were further subjected to gene ontology (GO) and pathway enrichment analysis, protein-protein interaction network establishment and survival ...hub genes correlated ... See full document
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<p>Identification of key genes, pathways and miRNA/mRNA regulatory networks of CUMS-induced depression in nucleus accumbens by integrated bioinformatics analysis</p>
... The 3 ′ -untranslated region (UTR) sequence of Gad1 mRNA was amplified and fused into the NotI and XhoI sites of psiCHECK2. The site-directed mutation of the detected miR-144-3p targeting site of Gad1 mRNA 3 ′ -UTR was ... See full document
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Original Article Identification of key genes and pathways in human glioblastoma multiforme by co-expression analysis
... Moreover, using plug-in MCODE in Cytoscape software, the 3 top clusters were ...1, genes in the 3 clusters were mainly associated with cell cycle regulation, cell division, and immune response, highlighting ... See full document
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Identification of key genes and pathways using bioinformatics analysis in septic shock children
... All DEGs were uploaded into the online software DAVID to evaluate the GO categories and KEGG pathways. The results revealed that the DEGs are significantly enriched in BP, such as inflammatory response, immune ... See full document
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Identification of differentially expressed genes and signaling pathways in ovarian cancer by integrated bioinformatics analysis
... 99 genes were upregulated and 91 genes were downregulated. Using R software, we identi- fied the top 20 most significantly up- and downregulated genes that could be the most related to the ... See full document
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Original Article Identification of key genes associated with idiopathic pulmonary fibrosis using bioinformatics analysis
... expressed genes (DEGs) between IPF and control ...module analysis for PPI net- work was performed using BioNet ...down-regulated genes were ...enrichment analysis indicated that PDGFRA ... See full document
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Original Article The identification of genes associated with NSCLC prognosis based on an integrated bioinformatics analysis
... expressed genes in NSCLC using a bioinformatics ...Up-regulated genes between cancer tissue and normal lung tis- sue from NSCLC patients were screened in the Oncomine ...up-regulated ... See full document
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Original Article Identification of key genes in preeclampsia-associated trophoblast cells using bioinformatics analysis
... GO analysis and KEGG pathway analysis. GO term enrichment analysis showed that nine DEGs were enriched in female pregnancy and three DEGs were enriched in embryonic neuro- cranium ...hub ... See full document
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Original Article Identifying key genes in rheumatoid arthritis using bioinformatics analysis
... Interacting Genes) to construct a PPI network to evaluate the rela- tionships among ...cluster analysis was utilized to construct subnetworks of the obtained PPI ...the genes related to the ... See full document
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Original Article Identification of the clinical diagnostic value of miR-10b-5p and the key targets and pathways in glioma, a study based on meta-analysis and bioinformatics
... target genes were collected from two GEO microarrays, TCGA glioblastomas (GBM) samples, and twelve prediction ...enrichment analysis showed that the target genes were mainly enriched in axon cargo ... See full document
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Original Article Identification of molecular target genes and key pathways in nasopharyngeal carcinoma by integrated bioinformatic analysis
... PPI network can help us obtain insights into interactions among DEGs, which correlate with oncogenesis, development and prognosis of NPC. The related information was gained by Search Tool for the Retrieval of Interacting ... See full document
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Original Article Identification of key pathways and candidate genes in gliomas by bioinformatics analysis
... In this study, we screened out 266 DEGs in gli- oma samples compared to normal controls by performing a differential expression analysis on a gene array downloaded from GEO data- base. Among these DEGs, CX3CR1 and ... See full document
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Original Article Dysregulated pathways identification analysis in Parkinson disease based on attractor of within-pathway effects and crosstalk inter-pathways
... dysregulated pathways in the pathogenesis of PD, gene expression profiling of 38 Parkinson’s disease patients and 23 healthy controls were ...expressed genes were identified in Parkinson’s ...27 ... See full document
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Original Article Candidate pathways and genes for nasopharyngeal carcinoma based on bioinformatics study
... of bioinformatics analyses were performed based on two human nasopharyngeal gene expression profiles and two human nasopharyngeal miRNAs expres- sion ...get genes were significantly enriched in 32 ... See full document
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Identification of key genes and pathways associated with neuropathic pain in uninjured dorsal root ganglion by using bioinformatic analysis
... performed using the Toppgene database followed by gene ontology and pathway enrichment ...analyzed using protein–protein interaction (PPI) network and module ... See full document
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Identification of key pathways and genes influencing prognosis in bladder urothelial carcinoma
... stage I disease and those without a tumor-staging report were excluded from further stratified and joint-effects analysis. A total of 402 BUC patients with advanced tumor stage (stages II, III, and IV) were ... See full document
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<p>Identification of key genes and pathways in Ewing’s sarcoma patients associated with metastasis and poor prognosis</p>
... the key genes on ES patients with/without metastasis were evaluated using GEO datasets and TCGA ...the key genes in pan-cancer TCGA study, ...the key genes was negatively ... See full document
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<p>Bioinformatics analysis of molecular genetic targets and key pathways for hepatocellular carcinoma</p>
... The miRNAs are a series of small, non-coding regula- tory RNAs, which regulate gene expression and perform a crucial role in the regulation of proliferation, cellular differentiation and cell death. A part of miRNAs was ... See full document
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Identification of key pathways and genes in <em>TP53 </em>mutation acute myeloid leukemia: evidence from bioinformatics analysis
... OS analysis for AML patients grouped by TP53 mutation revealed that AML patients with TP53 mutations had a shorter MST than those without TP53 mutations (TP53 mutations vs TP53 wild type, 31 days vs 608 days, ... See full document
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