[PDF] Top 20 PHI-base: a new database for pathogen host interactions

... various host organisms including humans, animals and ...web-accessible database to collate, cross-link and categorize genotypic and phenotypic informa- tion of individual pathogens and gene ... See full document

... of PHI-base. PHI- base version ...phenotype interactions compared to PHI-base version ...into PHI-base for the first time. The highest number of ... See full document

... The pathogen–host interactions database (PHI-base) was established in 2005 and is freely available at ...org. PHI-base contains expertly curated molecular and bi- ... See full document

... The PHI-base web-based curation tool will facilitate cu- ration of pathogen-host interactions from peer reviewed lit- erature into PHI-base by the authors doing the ... See full document

... The pathogen–host interactions database (PHI-base) is available at ...www.phi-base.org. PHI-base contains expertly curated molecular and biological information on ... See full document

... rice blast fungus Magnaporthe grisea, the ABC1 gene is a pathogenicity gene and the abc1 mutant is nonpathogenic in several different infection assays (Urban et al. 1999). Virulence genes affecting the degree of ... See full document

... to PHI-base was the inclusion of verified targets of known bioactive compounds (anti-infectives) which either kill pathogens or arrest pathogen ...in PHI-base cited by the British ... See full document

... orthologs mutating rapidly. Orthologs hence are functionally constrained by the same selective forces that determine the survival of a species and better reflect such species history. Several ways have been developed to ... See full document

... identified interactions are stored in a web-fronted relational-database, the Enhanced Infectious Disease Database (EID2) ...The database is continuously updated with new organisms, ... See full document

... DATA PHI-base annotations contain information about the host, the experimental condition and the resulting ...the PHI-base annotations associated with that gene, and a link to the gene ... See full document

... apposed host membrane around the bacterium. Host F-actin and signal transduction via ty- rosine phosphorylation are needed for entry, but the specific kinases involved are not ... See full document

... The results of one recent study illustrate the exten- sive allelic diversity that can be present in GAS. Lukomski et al. (18) identified an extracellular pro- tein with collagen-like characteristics that is present in ... See full document

... the pathogen and the overall infection efficiency also contribute to the observed high variability in infected cell (sub-) ...ideally host-pathogen interactions are studied on the single cell ... See full document

... BHB enhances R. oryzae virulence in mice due to overexpression of host GRP78 and R. oryzae CotH. To investigate whether our in vitro observations are relevant to mucormycosis pathogenesis, we compared the ... See full document

... in host-pathogen ...damage host cells as effectively as the multiple hypha structures formed by wild-type ...eukaryotic pathogen can play important roles in ... See full document

... was required for proper mucin secretion and normalisation of mucus with CF-like properties [46]. Other innate defence mechanisms against microbial growth, including the generation of reactive oxygen and nitrogen species, ... See full document

... a host species ...quantify host competence, i.e. the ability of a host to generate infection in another susceptible host [25, ...WNV host com- petence were able to pinpoint avian ... See full document

... genomic database provides a vast amount of useful information for the drug target ...the pathogen genome, differentially provides information about the genes that are likely to be essential to the ... See full document

... of host-pathogen protein-protein interactions (PPIs) on the basis of comparative interactomics of multiple strains is an effective strategy to highlight correlations between host proteome ... See full document

... the pathogen. Most endeavours have focussed on understanding host-pathogen interactions, primarily at the vertebrate ...Protein-carbohydrate interactions between the pathogen and ... See full document