[PDF] Top 20 Photoactivatable platinum (IV) anticancer complexes

... metal complexes with the ability to absorb two photons (usually large with highly conjugated donor and acceptor ligands) can be activated with longer and clinically relevant ... See full document

... Pt IV -succinato complex (22) for delivery of ...Pt IV precursor and CTX alone. The reduced activity of the Pt IV complex was attributed to its kinetic ... See full document

... Next, the in fl uence of the solvent was investigated. Radicals were also trapped after irradiation of 5 mM 1 in phosphate- bu ff ered saline (PBS) and in the culture medium RPMI-1640. Interestingly, the yield of azidyl ... See full document

... a platinum(IV) prodrug to cancer ...a photoactivatable diazido-Pt(IV) complex appended with dopamine, a neurotransmitter as well as a constituent of adhesive proteins in ...dopamine-conjugated ... See full document

... Y.Z. and H.L. thank the University of Warwick for PhD scholarships (WPRS and ORSAS awards). P.J.S and N.J.F. thank the EPSRC (EP/ G006792/1) and the ERC (award no. 247450) for support. N.J.F. thanks the EPSRC (Returners ... See full document

... These studies show for the rst time that photoactivation of the diazido Pt IV anticancer prodrug 1 can readily lead to a dual attack on peptide amino acids, either oxidation, or platination, or both. ... See full document

... corresponding anticancer active Pt (II) analogs are ...(IV) anticancer drugs is strongly influenced by their reduction po- tential [26] ...am(m)ine Platinum (IV) complexes are ... See full document

... In contrast, DATCP(IV) suppresses expression of a host of genes participating in many aspects of cellular processes like protein synthesis and turnover, replication, transcrip- tion, respiration, cell cycle ... See full document

... Pt(IV) complexes to enhance the comparison with available experimental data as previous theoretical study has shown that relativistic effects can have a significant effect on the simulated electronic ... See full document

... Platinum-based anticancer drugs are now widely used for the treatment of various types of cancer. 1–3 However, their utility in the clinic is severely limited by their systemic toxicity, as well as inherent ... See full document

... Photo-dark cytotoxicity. Approximately 10000 cells were seeded per well in 96-well plates. Independent duplicate plates were used, one for dark while the other for irradiation experiment. The cells were pre-incubated in ... See full document

... identical retention times and absorption spectra were verified by the synthesis of authentic samples of these species. The MS isotope distributions agreed very well with their corresponding simulations. (Figure 4.15) ... See full document

... other platinum-based anticancer drugs. 5,6 Platinum drugs are now used to treat over 40% of all cancer patients in chemotherapy since cisplatin was approved by FDA in 1978 to treat testicular and ... See full document

... these complexes bind significantly to 9-EtG but do not bind to ...II complexes 1, 4 and 10, results in a low degree of unwinding (6–7°) which is very similar for the three complexes but smaller than ... See full document

... metal complexes which possess anticancer ...metal-based anticancer drugs may be able to widen the spectrum of treatable cancers, reduce toxic side-effects, and overcome platinum ... See full document

... these complexes was investigated using six techniques including ultraviolet and fluorescence spectroscopy, linear dichroism, synchrotron radiation circular dichroism, isothermal titration calorimetry and mass ... See full document

... central platinum was at an angle to the portal of each Q[8] that allowed it to project an ammine ligand into each portal, which may have also reduced effective inter-Q[8] portal–portal repulsion, because the ... See full document

... metal complexes exhibited enhanced activities than the free ligands indicating that they are more efficient antibacterial ...metal complexes were equally shown to have encouraging antioxidant ... See full document

... where an intense MLCT band is present. However, this may not be practical for use in the clinic. Ultraviolet light is potentially harmful and so is not favoured. Red light penetrates deeper into tissue so is usually ... See full document

... 15 The smallest of the trans Se-Pt-P bond angles occurs in 1, with an angle of 169.82(5)°. Other than a bond angle of 173.40(14)° in 4, all the other trans bond angles in all three complexes are very close to ... See full document