[PDF] Top 20 A Powerful and Adaptive Association Test for Rare Variants
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A Powerful and Adaptive Association Test for Rare Variants
... more powerful SPU test may change with the varying ...other adaptive tests based on estimated (marginal) regression coefficients ...score-based test, requires only fitting a sim- plified model ... See full document
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Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits
... an association test, DKAT has four ...the association between an arbitrary set of traits and an arbitrary set of genetic ...can test the association between multiple traits and either ... See full document
12
Meta-Qtest: meta-analysis of quadratic test for rare variants
... burden test increases, Hom-meta-Q3, optimal type, becomes the most ...more powerful than Hom-meta-SKAT when it is ex- pected to outperform in a case of high causal percent- ...casual variants and ... See full document
15
Powerful association test combining rare variant and gene expression using family data from Genetic Analysis Workshop 19
... as rare variant, and performed rare variants analysis for the genes reported by hg19 build on the odd-number autosomes that have less than 50 rare variants and more than 1 rare ... See full document
5
Improved power by collapsing rare and common variants based on a data adaptive forward selection strategy
... select rare variants for each functional region also sug- gests that our method may have higher power to detect functional regions with an either positive (damage) or negative (protective) effect on the ... See full document
5
An adaptive association test for microbiome data
... association test. We, thus, propose a data-driven approach to achieve adaptive weighting of the taxa based on the ...an adaptive test called the aSPU test, which is based on a ... See full document
12
A Powerful Variant-Set Association Test Based on Chi-Square Distribution
... Genome-wide association studies (GWASs) have successfully identified thousands of single nucleotide poly- morphisms (SNPs) that are associated with some common diseases (Manolio et ...are variants with ... See full document
8
Comparative study of statistical methods for detecting association with rare variants in exome resequencing data
... Genome-wide association studies for complex traits are based on the common disease/common variant (CDCV) and common disease/rare variant (CDRV) ...genome-wide association studies using single-marker ... See full document
7
Evaluation of the power and type I error of recently proposed family based tests of association for rare variants
... analyze rare-variant association with binary phenotypes in complex ...containing variants with weak effects on the ...more powerful test ... See full document
5
A combined association test for rare variants using family and case control data
... imputed based on the sequenced individuals. Admixture analysis for the family data suggested that most of the fam- ily ancestry is European and Native American, where the proportions of the two ancestries in each ... See full document
5
Using the posterior distribution of deviance to measure evidence of association for rare susceptibility variants
... Genome-wide association studies usually rely on the common disease/common variant hypothesis: Poly- morphisms are genotyped and their association with dis- ease is ...causal variants [7]. The first ... See full document
6
Application of family based tests of association for rare variants to pathways
... single test statistic, whereas pathway-based tests operated in 2 stages ...causal variants in each gene, but each with strong risk, and the single-stage ... See full document
5
Exact association test for small size sequencing data
... to test disease associations of rare genetic ...for rare variants, aggregate information from all rare variants, in a specific genomic region, into a sin- gle summary variable ... See full document
11
A powerful microbiome-based association test and a microbial taxa discovery framework for comprehensive association mapping
... kernel association test (MiRKAT) [25] and microbiome-based sum of powered score tests (MiSPU) [26], and propose a new method, optimal microbiome- based association test (OMiAT), for more ... See full document
15
Association screening for genes with multiple potentially rare variants: an inverse probability weighted clustering approach
... gene-based association analysis for rare ...at rare variant loci. Association between the col- lapsed partition label and the disease traits can then be readily evaluated using single-marker ... See full document
6
Gene based analysis of rare and common variants to determine association with blood pressure
... SBP, DBP, and MAP. Although we used Lasso and SPLS only as variant selection methods, they can also be used to do the association test for genotype with complex traits. However, both Lasso and SPLS are very ... See full document
5
Association tests for rare and common variants based on genotypic and phenotypic measures of similarity between individuals
... genetic association studies for common complex genetic disorders will involve the analysis of rare and common ...joint association of rare and common variants that underlie quantitative ... See full document
8
Lack of association of rare functional variants in TSC1/TSC2 genes with autism spectrum disorder
... whether rare genetic variants in TSC1, TSC2, MYCBP2, RHEB and FBXO45, genes that regulate mTORC1 signaling and/or play a role in synapse development and function, contribute to the pathogenesis of ... See full document
11
Mapping the new frontier: complex genetic disorders
... most powerful method for identifying rare, high-risk alleles in Mendelian disease, many consid- er genetic association analysis to be the best method for identifying genetic variants related ... See full document
5
Detecting rare functional variants using a wavelet based test on quantitative and qualitative traits
... genome-wide association study on the Genetic Analysis Workshop 17 simulated unrelated individuals data using a multilocus score test based on wavelet transformation that we proposed ...wavelet-based ... See full document
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