[PDF] Top 20 Production and Characterization of Monoclonal Antibodies Specific for a Conserved Epitope within Hepatitis C Virus Hypervariable Region 1
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Production and Characterization of Monoclonal Antibodies Specific for a Conserved Epitope within Hepatitis C Virus Hypervariable Region 1
... common epitope presented by HVR1 C-terminus peptides was also present and cross-reactive at the HCV surface (20, ...the epitope confor- mation to react poorly (low affinity) with the ...of ... See full document
9
Definition of a Conserved Immunodominant Domain on Hepatitis C Virus E2 Glycoprotein by Neutralizing Human Monoclonal Antibodies
... residues within the HC HMAb epitopes that are engaged in E2-CD81 ...representative antibodies for epitope mapping ...This region contains Trp529, Gly530, and Asp535, which are known to be ... See full document
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Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes
... the hepatitis C virus (HCV), which likely contributes to immune escape, is most pro- nounced in hypervariable region 1 (HVR1) of viral envelope protein ...izing ... See full document
13
A Point Mutation Leading to Hepatitis C Virus Escape from Neutralization by a Monoclonal Antibody to a Conserved Conformational Epitope
... suppress hepatitis C virus (HCV) infection in experimental animals (11), coupled with subsequent correlations with antibody titers inhibiting HCV E2 glycoprotein binding to CD81 (16) and in vitro ... See full document
6
Role of Hypervariable Region 1 for the Interplay of Hepatitis C Virus with Entry Factors and Lipoproteins
... ApoE-specific antibodies to Jc1 and Jc1/⌬HVR1 ...cific antibodies or isotype-matched control ...polyclonal antibodies depleted viral in- fectivity to similar extents when incubated with ... See full document
12
Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region
... Surface plasmon resonance. All experiments were performed by us- ing a Biacore 2000 unit (GE Healthcare Life Sciences, United Kingdom). Protein ligands were buffer exchanged into 10 mM sodium acetate (pH 4.2) prior to ... See full document
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Isolation and Characterization of Broadly Neutralizing Human Monoclonal Antibodies to the E1 Glycoprotein of Hepatitis C Virus
... the epitope with the two MAbs in patterns that were unique to each antibody, but it did not abolish reactivity ...the epitope resulted in enhanced binding of IGH526 at eight amino acid positions and of ... See full document
8
Identification and characterization of monoclonal antibodies specific for polymorphic antigenic determinants within the V2 region of the human immunodeficiency virus type 1 envelope glycoprotein.
... in conserved residues within the V2 ...changes within the crown and C-terminal side of the V2 loop affect the reactivity of this set of MAbs (Table ...reside within peptides ... See full document
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Isolation and Characterization of Monoclonal Antibodies That Inhibit Hepatitis C Virus NS3 Protease
... of hepatitis C virus (HCV) is a multifunctional virus-specific protein that contains serine protease activity in its N-terminal region and accounts for processing of the viral ... See full document
9
Hypervariable Region 1 Differentially Impacts Viability of Hepatitis C Virus Strains of Genotypes 1 to 6 and Impairs Virus Neutralization
... tralizing antibodies, became significantly more susceptible when HVR1 was ...6a virus, which was highly susceptible to neutraliza- tion and which showed only a small increase in susceptibility when HVR1 was ... See full document
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Human Monoclonal Antibodies That Inhibit Binding of Hepatitis C Virus E2 Protein to CD81 and Recognize Conserved Conformational Epitopes
... Hepatitis C virus (HCV), a member of the family Flaviviridae, expresses its proteins from a ...The virus is highly variable, with more than nine distinct genotypes (1, ...neutralizing ... See full document
10
Conserved peptides within the E2 region of Hepatitis C virus induce humoral and cellular responses in goats
... human antibodies raised against hepatitis C virus (HCV) E2 epitopes do not offer protection against multiple viral infections may be related to either genetic variations among viral strains ... See full document
10
Sequence evolution of the hypervariable region in the putative envelope region E2/NS1 of hepatitis C virus is correlated with specific humoral immune responses.
... a specific immune response against HVR1 epitopes, there are no mutants that have a higher competitive ...detectable within a ...anti-HVR1 antibodies detected around 2,500 days after ...the ... See full document
6
Structural Flexibility of a Conserved Antigenic Region in Hepatitis C Virus Glycoprotein E2 Recognized by Broadly Neutralizing Antibodies
... immunodeficiency virus (HIV) has been reported to utilize conformational flexibility in the CD4 binding site within the en- velope protein gp120 as an immune evasion mechanism (re- viewed in reference ... See full document
12
Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine
... for virus-neutralizing anti- bodies in immunity against hepatitis C virus (HCV) ...cross-neutralizing monoclonal antibodies have been identified. These antibodies have been ... See full document
15
Occurrence of antibodies reactive with more than one variant of the putative envelope glycoprotein (gp70) hypervariable region 1 in viremic hepatitis C virus-infected patients.
... anti-HVR1 specific antibodies coexist in the bloodstream and even precede the viral sequence they ...of specific antibodies for 7 months. A single epitope, mapping at the ... See full document
6
Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422
... The hepatitis C virus (HCV) E2 envelope glycoprotein is crucial for virus entry into ...A conserved region of E2 en- compassing amino acids 412 to 423 (epitope I) and ... See full document
15
Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus
... izing antibodies. Epitope mapping of HC33-related antibodies revealed two ...this region, ...due within HVR1 that is located at aa ...anti-HVR1 antibodies can interfere with the ... See full document
11
Characterization and epitope mapping of Dengue virus type 1 specific monoclonal antibodies
... encephalitis virus (JEV) in different cross-reactivity ...sequence-unique epitope on the later-ridge of domain III of the DV1 E protein, centered near residues T346 and D360 ( 346 TQNGRLITANPIVTD 360 ...the ... See full document
11
Epitope mapping of antibodies directed against hypervariable region 1 in acute self-limiting and chronic infections due to hepatitis C virus.
... Hepatitis C virus (HCV) has been acknowledged as a major etiologic agent of acute and chronic hepatitis around the world since the cloning of its cDNA in 1989 ...a region of about 27 ... See full document
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