[PDF] Top 20 PrPc Expression Influences the Establishment of Herpes Simplex Virus Type 1 Latency
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PrPc Expression Influences the Establishment of Herpes Simplex Virus Type 1 Latency
... In our study we have utilized the TUNEL assay, which de- tects fragmented DNA, to measure apoptosis. It has been suggested that TUNEL identifies cells that have undergone not only apoptosis but also necrosis and ... See full document
12
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... the virus (TRL, terminal repeat long; IRL, internal repeat long; IRS, internal repeat short; TRS, terminal repeat short) that bound the unique long (UL) and unique short (US) ...resulting virus contains two ... See full document
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Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.
... A comparison of the induced reactivation frequencies of KOSM, KOS/1, KOS/29, and KOS/62 clearly demonstrates that both LATs- mutants KOS/29 and KOS/62 reactivated with a greatly reduced [r] ... See full document
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The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... Herpes simplex virus type 1 establishes latent infections in sensory ...During latency only one locus, the latency-associated transcript (LAT), is abundantly ...from ... See full document
9
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... and herpes simplex virus type 1 ...the virus can also enter a latent state in these ...The latency-associated transcript (LAT) regulates the establishment of the ... See full document
16
Enhancer and Long-Term Expression Functions of Herpes Simplex Virus Type 1 Latency-Associated Promoter Are both Located in the Same Region
... the expression of the LATs during latency is not significant ...mutant virus (termed 17⌬348) to reactivate following epinephrine-induced iontophoresis into the cornea in a rabbit model ...increased ... See full document
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Role of Dendritic Cells in Enhancement of Herpes Simplex Virus Type 1 Latency and Reactivation in Vaccinated Mice
... from virus replication in the eye or the establishment of latency in the TGs (47, 52), suggesting that protection against virus replication in the eye and the establishment of ... See full document
9
Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system.
... of herpes simplex virus type 1 (HSV-1) to establish a lifelong, transcriptionally active, latent infection in neurons has led to much interest in developing HSV-based vectors for ... See full document
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Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... Herpes simplex virus (HSV) establishes latency in sensory nerve ganglia during acute infection and may later periodically reactivate to cause recurrent ...HSV type 1 ... See full document
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ICP0 Gene Expression Is a Herpes Simplex Virus Type 1 Apoptotic Trigger
... Human herpes simplex virus type 1 (HSV-1) is a large DNA virus (25) whose infection is characterized by the establishment of latency in neuronal cells (60) ... See full document
12
Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... LAT expression during latency, the LAT-specific primer pair LAT1 (59-ACGAGGGAAAACAATAAGGG) and LAT2 (5 9 -GACAGCAAAAATCCCCTGAG) (25) ...myeloblastosis virus reverse transcriptase (Promega) as ... See full document
10
Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglia by in situ reverse transcriptase PCR.
... of herpes simplex virus type 1 (HSV-1) infection is the ability of the virus to establish a lifelong latent state in ...HSV latency-associated tran- scripts ...LATs ... See full document
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The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... mutant has been verified now with both mouse and guinea pig models (13, 27). More importantly, no complementation of this deficiency could be detected in transgenic mice that harbored prominent amounts of the major LAT ... See full document
7
The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency.
... during latency, as we had to delete the LTE from the PstI site to the HpaI in order to fit two copies of the lacZ gene into the ...long-term expression of the LAT ...long-term expression to the LAT ... See full document
6
Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... any protein, it is able to change its host fate. Many investigations have revealed that it could interfere in cellular pathways. To explore the effect of LAT on neuroblastoma cells, the BE- 2(c) cells were subjected to ... See full document
8
Mechanisms of herpes simplex virus type 1 reactivation.
... from herpes simplex virus type 1 (HSV-1) latently infected mice were used to study ...reactivation. Expression of HSV-1 latency-associated transcripts was ... See full document
10
Analysis of Protein Expression from within the Region Encoding the 2.0-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1
... Plasmid construction. The plasmid pcDNA-Pst/Mlu (55) containing the PstI- MluI restriction fragment of the HSV-1 strain F LAT gene (Fig. 1) served as the parental construct from which all other clones were ... See full document
14
Gamma Interferon Can Block Herpes Simplex Virus Type 1 Reactivation from Latency, Even in the Presence of Late Gene Expression
... Construction of promoter-EGFP viruses. Two recombinant HSV-1 strains expressing enhanced green fluorescent protein (EGFP) from viral promoters were produced for this study (RE-pICP0-EGFP and RE-pgC-EGFP). Both ... See full document
9
Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice.
... Kovler Viral Oncology Laboratories, The University of Chicago, Chicago, Illinois 606371; Medical Research Council Herpes Virus Research Group, Department of Microbiology, University of L[r] ... See full document
9
In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... during latency among all of the more than 70 HSV type 1 (HSV-1) ...enhanced expression in neuroblastomas relative to HeLa cells (1, ... See full document
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