[PDF] Top 20 Pulmonary function tests as outcomes for systemic sclerosis interstitial lung disease
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Pulmonary function tests as outcomes for systemic sclerosis interstitial lung disease
... of pulmonary arterial hypertension (PAH), FVC is believed to be more specific than D LCO to ILD [227, ...the lung for carbon monoxide (K CO ) and V A ... See full document
16
Low dose oral imatinib in the treatment of systemic sclerosis interstitial lung disease unresponsive to cyclophosphamide: a phase II pilot study
... the lung characterized by ground-glass (Figure ...vanced lung disease – treating patients at an earlier stage could be more rewarding, as suggested by the lack of effect of imatinib on established ... See full document
10
Abstract
... 158 systemic sclerosis patients with interstitial lung disease confirmed by bronchoalveolar lavage fluid and HRCT were treated with oral CYC ( ≤ 2 mg/kg/day) or placebo for 1 ...on ... See full document
6
Predictors of lung function decline in scleroderma related interstitial lung disease based on high resolution computed tomography: implications for cohort enrichment in systemic sclerosis–associated interstitial lung disease trials
... Systemic sclerosis–associated interstitial lung disease (SSc-ILD) is common, is associated with a poor progno- sis, and is the leading cause of death in people with SSc ...in ... See full document
10
Systemic sclerosis associated interstitial lung disease individualized immunosuppressive therapy and course of lung function: results of the EUSTAR group
... of lung function under treatment was evaluated by linear regres- sion analysis of change in DLCO and FVC from treat- ment start to at least one follow-up ...initial lung func- tion, but afterwards ... See full document
12
<p>Interstitial Lung Disease in Systemic Sclerosis: Focus on Early Detection and Intervention</p>
... Abstract: Systemic sclerosis (SSc) is a progressive and often devastating disease characterized by autoimmune dysfunction, vasculopathy, and fi ...brosis. Interstitial lung ... See full document
25
Pulmonary hypertension in systemic sclerosis: different phenotypes
... complex disease characterised by skin involvement and a variable degree of organ involvement, including both the lungs and the heart ...small pulmonary arteries (group 1 of the updated PH classification ... See full document
6
Personalised medicine in interstitial lung diseases
... on pulmonary function trends because of the need for early cessation of the triple-therapy ...in outcomes existed according to TOLLIP status ... See full document
12
Isolated pulmonary veno-occlusive disease and pulmonary arterial thrombosis in systemic sclerosis – a lethal combination
... On systemic examination patient was hemodynamically stable, but had marked jugular venous pulsations and pitting edema up to her ...renal function tests revealed her creatinine, at 420 µ mol/L, was ... See full document
5
Changes in plasma CXCL4 levels are associated with improvements in lung function in patients receiving immunosuppressive therapy for systemic sclerosis related interstitial lung disease
... potentially disease-modifying therapy (MMF, intravenous CYC, rituximab, tocilizumab, intravenous immunoglobu- lin, or azathioprine) and these alternative therapies may have influenced the results ... See full document
9
Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
... of pulmonary function in patients with SSc have shown remarkable variability in the progression of restrictive lung disease, ranging from an indolent course with stable PFT values to a rapidly ... See full document
11
Contribution of pulmonary function tests (PFTs) to the diagnosis and follow up of connective tissue diseases
... Surgical Lung Biopsy (SLB) is Usual Interstitial Pneu- monia (UIP), followed by Nonspecific Interstitial Pneu- monia (NSIP) and rarely other patterns ...active disease, presence of rheumatoid ... See full document
11
Interstitial lung disease in systemic sclerosis: where do we stand?
... In SSc, no antifibrotic drug has shown a real efficacy in prevention and treatment of fibrosis. The tyrosine kinase inhibitor, imatinib mesilate, blocks the pro-fibrotic c-Abl kinase, an important downstream signalling ... See full document
9
Predicting Lung Function Decline with Serum Pneumoproteins: A Case Control Study
... of lung function decline in systemic sclerosis (SSc) are ...with pulmonary damage. We aimed to test whether levels can predict rapid lung function decline in ...serial ... See full document
6
Immunosuppression for interstitial lung disease in systemic sclerosis
... threatening pulmonary fibrosis or pulmonary ...on pulmonary function was recorded ...the lung for carbon monoxide (T LCO ) were used to evaluate pulmonary function and a ... See full document
8
<p>Epidemiology of systemic sclerosis and systemic sclerosis-associated interstitial lung disease</p>
... Eight publications reporting survival and mortality data in SSc patients in North America were identi fi ed during the systematic review. Data suggest that survival duration after SSc diagnosis has improved over time, ... See full document
17
Does high-dose extended course cyclophosphamide and methylprednisolone pulse therapy have a role in the management of systemic sclerosis-related interstitial lung disease?
... 3. Hoyles RK, Ellis RW, Wellsbury J, et al. A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the ... See full document
8
Angiogenic activity of sera from interstitial lung disease patients in relation to pulmonary function
... the disease course is ...of lung fibrosis develop- ment or an element of the lung’s defence against the destructive impact of ...in lung tissue of IPF patients and experimental drug-in- duced ... See full document
6
Usefulness of lung ultrasound B lines in connective tissue disease associated interstitial lung disease: a literature review
... 13]. Interstitial lung disease is a frequent parenchymal manifestation of ...although pulmonary function tests (PFTs) are valuable in screening and following-up for CTD-ILD, they ... See full document
9
New onset non infectious pulmonary manifestations among patients with systemic lupus erythematosus in Sweden
... of lung disease and whether lung manifestations occur early in SLE, using the Swedish Lupus Linkage (SLINK) ...monary disease in individuals with SLE compared to those without ...of ... See full document
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