[PDF] Top 20 Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.
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Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.
... in CD4-mediated activation of Env fusogenicity, dependence on cellular CD4 density, and sCD4 enhance- ment of ...in CD4 induction of the fusogenic potential of Env; ...of CD4 on the Env ... See full document
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Neutralization Synergy of Human Immunodeficiency Virus Type 1 Primary Isolates by Cocktails of Broadly Neutralizing Antibodies
... between antibody binding and neutral- ization has been observed in studies with T-cell-line-adapted strains of HIV-1, such as the HxB2 molecular clone of HIV-1 used ... See full document
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Study of the V3 Loop as a Target Epitope for Antibodies Involved in the Neutralization of Primary Isolates versus T-Cell-Line-Adapted Strains of Human Immunodeficiency Virus Type 1
... TCLA strains (23, 64, 73) and because their presence could be correlated with the protection against homologous challenge found in chimpanzees (15), the V3 loop has been used to elaborate vaccine and therapeutic ... See full document
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Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.
... the primary virus envelope glycoproteins demonstrated less sensitivity to neutralizing antibodies directed against the CD4-binding site or the V3 loop, relative to that seen for the HXBc2 envelope ... See full document
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Antibody-mediated neutralization of primary isolates of human immunodeficiency virus type 1 in peripheral blood mononuclear cells is not affected by the initial activation state of the cells.
... of virus-specific neutralizing antibodies de- tected in biological assays depends upon the extent to which the in vitro assay predicts antibody function in ...vivo. Antibody- mediated ... See full document
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Antibody-Mediated Neutralization of Primary Human Immunodeficiency Virus Type 1 Isolates: Investigation of the Mechanism of Inhibition
... the neutralization of PI may be largely ...by antibody mapping (7, 32, 34) have been found to be exposed on several TCLA strains but occluded or masked on PI (5, ...cross-clade neutralization ... See full document
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CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1.
... the CD4, CXCR-4, and CCR-5 dependen- cies for infections by diverse primary patient (PR) and laboratory-adapted (LA) isolates of human immuno- deficiency virus type ... See full document
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Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Primary Isolates to Antibodies and CD4-Based Reagents Is Independent of Coreceptor Usage
... the T-tropic phenotype in primary ...M-tropic virus and a TCLA one. However, the passage of a T-tropic primary virus through a cell line to create a TCLA isolate is ... See full document
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Equal levels of gp120 retention and neutralization resistance of phenotypically distinct primary human immunodeficiency virus type 1 variants upon soluble CD4 treatment.
... sCD4 neutralization sensitivity (22, 25, 34), SI capacity (2, 11, 17), and cytotropism (6, 21, 25, 35, ...a T-cell line, does not segregate with sCD4 sensitivity at 37 8 ...in T cells ... See full document
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Continued Utilization of CCR5 Coreceptor by a Newly Derived T-Cell Line-Adapted Isolate of Human Immunodeficiency Virus Type 1
... of human immunodeficiency virus ...of primary isolates (PI) to growth in established T-cell ...the T-cell line-adapted (TCLA) viruses studied ... See full document
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Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1.
... for antibody neutralization of HIV (14, 26, 31, ...NSI isolates possess cryptic V3 loop epitopes, at least in part inaccessible for antibody binding (3), suggesting a possible explanation for ... See full document
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Antibody Binding and Neutralization of Primary and T-Cell Line-Adapted Isolates of Human Immunodeficiency Virus Type 1
... the neutralization- resistant PI and neutralization-sensitive TCLA Envs was ...(Tables 1 and 2) was detected under saturating conditions, but neutralization potency against the ...TCLA ... See full document
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Stoichiometry of Monoclonal Antibody Neutralization of T-Cell Line-Adapted Human Immunodeficiency Virus Type 1
... body neutralization, it was proposed that Env spike density could be an important modifier of sensitivity to antibody neu- tralization if this occurred through an occupancy/threshold mechanism, perhaps ... See full document
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Macrophage-tropic and T-cell line-adapted chimeric strains of human immunodeficiency virus type 1 differ in their susceptibilities to neutralization by soluble CD4 at different temperatures.
... Using molecular chimeras of a macrophage-tropic primary virus JR-FL and a T-cell line-adapted virus NL4-3, we have previously shown that sCD4 resistance and macrophage tropism can both s[r] ... See full document
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Antibody Neutralization-Resistant Primary Isolates of Human Immunodeficiency Virus Type 1
... of soluble gp120 and gp41 from resistant vi- ruses with MAbs. Neutralization resistance seems to be possi- ble through at least two ...tralizing antibody to the virion may occur, as has been de- ... See full document
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Differential regulation of cellular tropism and sensitivity to soluble CD4 neutralization by the envelope gp120 of human immunodeficiency virus type 1.
... DISCUSSION Using a set of recombinant and mutant viruses generated between two molecularly cloned HIV-1 isolates, HIV-1sF2 a T-cell-line-tropic virus and HIV-1sF162 a macrophage-tropic v[r] ... See full document
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Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody.
... ROBINSON' Received 23 August 1990/Accepted 12 October 1990 A human monoclonal antibody designated 15e is reactive with the envelope glycoprotein gpl20 of multiple isolates of human immun[r] ... See full document
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Two mechanisms of soluble CD4 (sCD4)-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4.
... Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gpl20.. Identific[r] ... See full document
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Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.
... To test whether the expression of the consensus Nef protein also correlated with a decrease in surface CD4 expression, the transduced HuT-78 and AKR1-G1 cells were stained for human or m[r] ... See full document
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Cross-neutralization of human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus isolates.
... 3602 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest In contrast to infrequent and low-titer cross-neutralization of human immunodeficiency virus type 1 HIV-1 isolates b[r] ... See full document
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