[PDF] Top 20 In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.
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In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.
... From studies of HSV-1 LAT+ and LAT- viruses in the rabbit model using both in vitro and in vivo reactivation techniques, the data support and extend previous conclusions that i LAT expre[r] ... See full document
5
In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-base-pair region located between the promoter and the 5' end of the 2.0 kilobase latency-associated transcript.
... induced reactivation in the ...induced reactivation in the ...adrenergic reactivation. Two new viral constructs (Fig. 1) will be tested for their abilities to undergo adrenergi- cally induced ... See full document
5
Sodium Butyrate: a Chemical Inducer of In Vivo Reactivation of Herpes Simplex Virus Type 1 in the Ocular Mouse Model
... The herpes simplex virus type 1 (HSV-1) genome establishes latency in sensory neurons, where it exists as a circular episome associated with histones (6, 16, ...the ... See full document
5
cis-acting elements involved in transcriptional regulation of the herpes simplex virus type 1 latency-associated promoter 1 (LAP1) in vitro and in vivo.
... during latency: (i) KOS/29, a virus with a deletion of LAP1 at both loci, does not express LAT during latency (6, 10, 11, 13); (ii) variant 1704, which is similar to KOS/29 but retains some ... See full document
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Regions of the Herpes Simplex Virus Type 1 Latency-Associated Transcript That Protect Cells from Apoptosis In Vitro and Protect Neuronal Cells In Vivo
... In what context does the LAT region of the genome exert an antiapoptotic effect? Initially, we hypothesized that the intact stable 2.0-kb LAT intron that was expressed by the pcDNA3.Pst-Mlu plasmid was a likely candidate ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... of latency is not yet ...apoptotic rabbit neurons does not work on rabbit cells (81), and the validity of the assays employed to detect apoptosis and the results obtained in that study have therefore ... See full document
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Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype
... The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for the high spontaneous and induced reactivation ... See full document
6
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... in reactivation per ...wild type in vivo in this site (32). Following infection via the eye or snout, establishment is less efficient in TG neurons and reactivation is delayed in ... See full document
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Region of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Culture
... spontaneous reactivation by ...spontaneous reactivation, additional LAT de- letion mutants were constructed and tested in the rabbit ocular latency ...marker-rescued virus dLAT2903R, ... See full document
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Herpes simplex virus genome replication and transcription during induced reactivation in the rabbit eye.
... of herpes simplex virus (HSV) genome replication and productive-cycle transcription was used to examine the role of the cornea in the latency-associated transcript (LAT)-mediated ... See full document
9
Evidence that the Herpes Simplex Virus Type 1 ICP0 Protein Does Not Initiate Reactivation from Latency In Vivo
... of latency, including the number of latently infected neu- rons and the number of viral genomes present in individual neurons, were ...in vitro reactivation of ⌬ Tfi 22 h postexplant was ... See full document
12
Mutations in the 5' end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpes.
... in 1 ml of RNA Stat-60 with a Tekmar ...in vitro tran- script, derived by T7 RNA polymerase from plasmid pHSV2e, which had been linearized at an XbaI ...About 1 ng of sample RNA in 5 m l was added to ... See full document
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A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... ocular herpes simplex virus type 1 (HSV-1) infection, the virus travels up axons and establishes a lifelong latent infection in neurons of the trigeminal ... See full document
12
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... The latency-associated transcript (LAT) gene the only herpes simplex virus type 1 (HSV-1) gene abundantly transcribed during neuronal latency, is ... See full document
7
A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse
... The latency-associated transcript (LAT) is essential for the wild-type herpes simplex virus type 1 (HSV-1) high-reactivation phenotype since ... See full document
10
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... Latency-associated transcript (LAT) promoter deletion mutants of herpes simplex virus type 1 have a reduced capacity to reactivate following adrenergic induction in ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... neous reactivation, the region ...taneous reactivation, but the effects of this must not be ...spontaneous reactivation possible in the rabbit ...spontaneous reactivation in the ... See full document
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In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... in vitro and in vivo ...in vivo. A synthetic hammerhead ribozyme targeting the HSV-1 LAT 5= exon ...cotransfecting rabbit skin cells with this plasmid alongside a LAT expression plasmid ... See full document
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Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... to 1 g/ml in preheated (55°C) hybridization buffer (50% formamide, 1 ⫻ Denhardt’s solution, 10 mM EDTA, 10% dextran sulfate, ...FIG. 1. Diagram of the HSV-1 LAT region and the LAT transgene ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... erty associated with a number of cellular transcriptional en- hancers (18), and it is important to note that enhancer activi- ties have previously been associated with the region of LAT containing the 5 ⬘ ... See full document
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