[PDF] Top 20 Replication-Competent Controlled Herpes Simplex Virus

... to replication of a virus or viral ...oncolytic virus, reduced replication capability would be expected to be directly reflected in lower oncolytic ...wild-type virus and an attenuated ... See full document

... challenge virus replicated to low titers at the site of inoculation; therefore, the vaccine strain did not provide sterilizing ...latent virus was recovered by DRG explant cocultures from <10% of vaccinated ... See full document

... within the standard 3-week observation period (10, 47). In prior studies, we were unable to detect an LD 50 for G207 after i.c. inoculation in mice or Aotus nancymae primates (25, 57). However, as part of the preclinical ... See full document

... expressed herpes simplex virus 1 (HSV-1) regulatory protein ICP22 coupled with mass spectrometry-based proteomics technology and subsequent analyses showed that ICP22 interacted with p53 in ... See full document

... percent activity was determined by performing the assay in the absence of TTP. 4B and C) ribonucleotide reductase activity in both HSV-1 and HSV-2 infected cell extracts was markedly res[r] ... See full document

... Abstract Herpes simplex virus - 1 (HSV-1) is a common human double-stranded DNA virus that can cause a variety of pathologies, including recurrent oral lesions in the immunocompetent ... See full document

... Human embryonic lung (HEL) cells infected with human cytomegalovirus (HCMV) restricted the replication of herpes simplex virus type 1 (HSV-1).. A delay in HSV replication of 15 h as well[r] ... See full document

... to virus-mediated gene therapy, where viral replication and associated cytotoxicity are limited to a specific cell type by the regulated expression of an essential immediate-early viral gene ...a ... See full document

... DISCUSSION Replication-competent viral vectors that are cytotoxic have a number of attractive features for tumor therapy, such as the abilities to generate new infectious virus in situ while killing ... See full document

... It is also possible that early gene expression in cells infected by HSV-1 strains which have an intact IE 3 gene contributes to the induction of CPE, particularly since IE 3-expressing s[r] ... See full document

... Proteins from herpes simplex virus (HSV)-infected cells were used to reconstitute DNA synthesis in vitro on a preformed replication fork.. The preformed replication fork consisted of a n[r] ... See full document

... with herpes simplex virus type 1 (HSV-1) results in the rapid elimination of mitochondrial DNA (mtDNA) from host ...viral replication or the biology of HSV-1 in- ...viral replication, ... See full document

... in herpes simplex virus 1-infected cells, ICP22 upregulates the accumulation of a subset of ␥ 2 proteins exemplified by the products of the U L 38, U L 41, and U S 11 ...infectious virus ... See full document

... The herpes simplex virus type 1 (HSV-1) neurovirulence gene encoding ...ICP34.5-null virus to counteract the induction of translational arrest through the PKR antiviral pathway, the role of ... See full document

... whereby virus infections induce immune reactions that subse- quently involve self components (34, ...of virus replication in initiating ...although virus and demon- strable antigens are absent ... See full document

... the herpes simplex virus 1 (HSV-1) life cycle, a viral nucleocapsid buds into a vesicle of trans-Golgi network (TGN)/endosome origin, acquiring an envelope and an outer vesicular ...The ... See full document

... Recently, a method has been developed to identify regions in the genome of herpes simplex virus type 1 (HSV-1) which contain genes required for DNA synthesis from an HSV-1 origin of DNA [r] ... See full document

... The HSV replication genes code for enzymes and factors directly involved in viral DNA replication (33), namely, the HSV DNA polymerase (encoded by the UL30 gene), the single- stranded (m[r] ... See full document

... DNA replication our data shows that gamma2- genes produce a transcription-complex that recruits ...beta-free virus using bacterial artificial chromosomes and complementing them with stably transfected ... See full document

... The hydrophobic residues in the NES are important for nuclear export of VP19C, and VP19C is exported from the nucleus through the NES via a CRM1-dependent pathway. However, CRM1-mediated transport is highly subjected to ... See full document