[PDF] Top 20 Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice.
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Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice.
... of replication or to de- creased infectivity of these ...wild-type virus infections of the standard 100 IU (1 3 ...with 1 3 wild-type or 10 3 vpr-minus strain and eight of nine ... See full document
7
Tropism of varicella-zoster virus for human CD4+ and CD8+ T lymphocytes and epidermal cells in SCID-hu mice.
... the SCID-hu mouse model exhibits significant differences in cell tropism compared with human ...VZV, human cy- tomegalovirus replicates in the thymic epithelial cells only and does not cause ... See full document
8
Reduced viral load and lack of CD4 depletion in SCID-hu mice infected with Rev-independent clones of human immunodeficiency virus type 1.
... The SCID-hu mouse system has been established as a useful in vivo model to study aspects of HIV-1 replication and patho- genesis (2, 6, ...The SCID-hu mice are produced by ... See full document
6
Human Immunodeficiency Virus Type 1 Pathogenesis in SCID-hu Mice Correlates with Syncytium-Inducing Phenotype and Viral Replication
... HIV-1 replication in thymus/liver grafts exhibits a threshold characteristic with respect to cytopathic effects on CD4 CD8 DP ...viral replication, where 50% of the CD4 CD8 DP cells are depleted, is ... See full document
9
Human Immunodeficiency Virus Type 1 Strains R5 and X4 Induce Different Pathogenic Effects in hu-PBL-SCID Mice, Depending on the State of Activation/Differentiation of Human Target Cells at the Time of Primary Infection
... Human immunodeficiency virus type 1 (HIV-1) replication is a dynamic process influenced by a combination of viral and host factors, whose interactions may shape the ... See full document
7
Selective Regulation of Human Immunodeficiency Virus-Infected CD4+ Lymphocytes by a Synthetic Immunomodulator Leads to Potent Virus Suppression In Vitro and in hu-PBL-SCID Mice
... cellular gene which is required for successful proviral DNA ...FIG. 1. Murabutide suppresses HIV-1 replication in CD8-depleted lymphocytes from HIV-1 ... See full document
12
Naturally occurring accessory gene mutations lead to persistent human immunodeficiency virus type 1 infection of CD4-positive T cells.
... of human immunodeficiency virus type 1 (HIV-1) consists of major structural genes (gag, pol, and env), regulatory genes (tat and rev), and accessory genes (vif, vpr, vpu, ... See full document
12
Pathogenesis of Primary R5 Human Immunodeficiency Virus Type 1 Clones in SCID-hu Mice
... viral replication (one copy of HIV-1 DNA for every 5 to 8 cells) is ...viral replication yield large effects on thymocyte depletion, while at higher levels of viral replication increases in ... See full document
12
Coinfection of SCID-hu Thy/Liv Mice with Human Herpesvirus 6 and Human Immunodeficiency Virus Type 1
... HHV-6 replication in implants coinfected with HIV-1 was observed in some of the conditions tested (see ...the replication of HHV-6 in vitro ...in SCID-hu Thy/Liv mice suggests ... See full document
6
Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood monoclonal cells.
... env gene from the cultured cells, from peritoneal cells harvested from Hu-PBL-SCID mice, or from cDNA obtained by reverse transcribing viral RNA present in supernatant fluid from the primary ... See full document
8
Primary Human Immunodeficiency Virus Type 1 Nef Alleles Show Major Differences in Pathogenicity in Transgenic Mice
... susceptibility/resistance, virus pathogenicity, or both ...of virus replication and immune response to HIV-1 as well as the signaling pathways with which the viral proteins may ...CCR5 ... See full document
17
Human Immunodeficiency Virus Type 1 Infection and Replication in Normal Human Oral Keratinocytes
... The present data are consistent with previous studies show- ing CD4-independent infection of epithelial cells derived from the intestine (15, 46) and oligodendrocytes (8). NHOKs bear GalCer and CXCR4, and inhibition ... See full document
7
Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8+T Cells and Associated with a Proliferative Response to p24 Antigen
... of virus in plasma are a heterogeneous group, a small subgroup of patients with truly nonprogressive human immu- nodeficiency virus (HIV) infection likely hold important clues to the basis of an ... See full document
6
Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA.
... We have therefore generated cysteine array mutants in an infectious proviral clone of human immunodeficiency virus type 1 HIV-1.. As described in the current report, these mutants give r[r] ... See full document
5
Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR.
... Our data show that PKRLS9 can induce the activation of NF- k B, and this may also be responsible for the high levels of HIV-1 replication in Jurkat/PKRLS9 cells. Considering the ability of PKR to ... See full document
8
A Functional Role for ADAM10 in Human Immunodeficiency Virus Type 1 Replication
... A role for ADAM10 during nuclear trafficking is in concert with known cellular roles for this complex pro- tein. The protein has several known extracellular domains, which include a metalloprotease domain, an integrin ... See full document
14
Integrase mutants of human immunodeficiency virus type 1 with a specific defect in integration.
... A previous analysis of single amino acid substitutions in the human immunodeficiency virus type 1 HIV-1 integrase protein failed to identify mutations that only blocked the integration o[r] ... See full document
5
Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.
... CD4 1 Th1- or Th2-like cell cultures. CD4 1 Th1- or Th2-like bulk cell cultures were prepared as described previously ...CD4 1 T cells were purified from nonadherent PBMC with Dynabeads M450 (Dynal, ... See full document
11
Spontaneous mutations in the human immunodeficiency virus type 1 gag gene that affect viral replication in the presence of cyclosporins.
... inhibits human immunodefi- ciency virus type 1 (HIV-1) replication (11, ...inhibit virus replication (2, 4, 16), and it was observed that the antiviral activities ... See full document
9
Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants.
... The two regulatory protein coding regions for tat and rev that are essential for virus replication are intact, and transient expression of HIVgpt in COS7 cells results in assembly and re[r] ... See full document
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