[PDF] Top 20 Rex transregulation of human T-cell leukemia virus type II gene expression.
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Rex transregulation of human T-cell leukemia virus type II gene expression.
... In this regard, Rex resembles the Rev protein of human immunodeficiency virus type 1 HIV-1 that augments the cytoplasmic expression of unspliced HIV-1 mRNAs 28, 29 and functions through [r] ... See full document
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The human T-cell leukemia virus type 1 Rex regulatory protein exhibits an impaired functionality in human lymphoblastoid Jurkat T cells.
... The Rex protein of human T-cell leukemia virus type 1 (HTLV-1) intervenes in the posttranscriptional regulation of proviral gene ...the Rex response element ... See full document
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The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes.
... HTLV-induced T-cell transformation re- mains ...adult T-cell leukemia do so after a 25- to 30-year latent ...Tax expression are low or absent in leukemic cells, suggesting that ... See full document
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Human T-Cell Leukemia Virus Type 1 Tax Relieves Repression of Proliferating Cell Nuclear Antigen Gene Expression
... through cyclic AMP response element and activating transcrip- tion factor-1 (CRE/ATF-1), nuclear factor B (NF- B), and serum response element (SRE) pathways. We have previously shown that Tax is able to transactivate ... See full document
9
Influence of human T-cell leukemia virus type I tax and rex on interleukin-2 gene expression.
... 67, 1993 HTLV-I tax AND rex INFLUENCE ON IL-2 GENE EXPRESSION structs also confirm this observation, because expression of tax and rex in those experiments is promoted by the HTLV-I DISC[r] ... See full document
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Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1
... CRM1 gene was amplified by PCR with the primer pair 59-GGAAGATCTTTCAATCTCTGGT TATCTATGCCAGC-39 and CRM2 and with the first PCR product described above as a ...of Rex derived from pSRaTAgRexM64 by digestion ... See full document
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Characterization of ribosomal frameshifting for expression of pol gene products of human T-cell leukemia virus type I.
... To identify the frameshift site in the pro-pol overlap, we determined a portion of the amino acid sequence of a protein produced by ribosomal frameshifting in an in vitro translation sys[r] ... See full document
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Phosphorylation regulates RNA binding by the human T-cell leukemia virus Rex protein.
... 4325 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest The Rex protein of human T-cell leukemia virus types I HTLV-I and II HTLV-II regulates the expression of the viral s[r] ... See full document
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Phosphorylation of Two Serine Residues Regulates Human T-Cell Leukemia Virus Type 2 Rex Function
... Plasmids. Rex expression vector BC20.2, containing HTLV-2 tax/rex cDNA expressed from the cytomegalovirus (CMV) immediate-early gene promoter, has been described earlier (14, ...Various ... See full document
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Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo
... The Rex-2 mutants were transiently cotransfected into 293T cells with pcTat and pCgagRxRE-II, along with a CMV-luc transfection efficiency ...of Rex-2 that displayed significantly reduced function ... See full document
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Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation.
... the virus life cycle for the sequences between env and the last exon of ...in cell culture but plays a critical role in pathogenicity and the development of AIDS when assayed in monkeys ...the human ... See full document
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Construction of recombinant murine retroviruses that express the human T-cell leukemia virus type II and human T-cell lymphotropic virus type III trans activator genes.
... Functional tat II and tat III gene products were expressed as demonstrated by trans activation of HTLV type I and II and human T-cell lymphotropic virus type III long terminal repeat-dir[r] ... See full document
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Silencing of human T cell leukemia virus type I gene transcription by epigenetic mechanisms
... tax gene transcription was analyzed ...tax gene transcripts (Case 1, 9, 12, 20), 5'-LTR was not methylated or slightly ...higher expression of tax gene is asso- ciated with unmethyalted or ... See full document
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Rat CRM1 Is Responsible for the Poor Activity of Human T-Cell Leukemia Virus Type 1 Rex Protein in Rat Cells
... of Rex in rat ...infected human cells despite the fact that Tax/Rex mRNA is abundantly produced in both cell types ...that Rex function may be impaired in rat cells. To test Rex ... See full document
11
Human T-cell leukemia virus type II Rex binding and activity require an intact splice donor site and a specific RNA secondary structure.
... Here, using an immunobinding assay to measure the binding of Rex protein to mutated RxRE RNAs, we show that efficient Rex binding requires a stem-bulge-loop RNA secondary structure nucle[r] ... See full document
9
Human T-Cell Leukemia Virus Type 2 Rex Carboxy Terminus Is an Inhibitory/Stability Domain That Regulates Rex Functional Activity and Viral Replication
... carboxy-terminal Rex-2 phosphorylation do- main and to address whether the ability to regulate Rex func- tion is important for HTLV-2-mediated cellular proliferation and immortalization in vitro and ... See full document
12
Phosphorylation regulates human T cell leukemia virus type 1 Rex function
... The Rex-1 expression vector SE356, which contains the HTLV-1 tax/rex cDNA expressed from the cytomegalovirus (CMV) immediate-early gene promoter, was described previously ...S-tagged ... See full document
11
Transrepression of lck gene expression by human T-cell leukemia virus type 1-encoded p40tax.
... TK II (5 9 -GGTCA TGTGT GCAGA AGCTG-3 9 , nucleotides 246 to 265, antisense mRNA), b globin I (5 9 -ACACA ACTGT GTTCA CTAG C-3 9 , nucleotides 14 to 33, sense), b globin II (5 9 -CAACT TCATC CACGT TCACC-3 9 ... See full document
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Activation of Human T-Cell Leukemia Virus Type 1tax Gene Expression in Chronically Infected T Cells
... HTLV-1 gene activation by the different activating agents used in our studies are likely to be ...stimulates expression of many cellular and viral genes through the inhibition of histone deacetylases (50), ... See full document
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Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function.
... The rex genes encoded by the mutant clones pLHRexM2, pLHRexM7, and pLHRexM8 were able to inhibit wild-type function of the HIV-1 Rev protein Fig.. The expression of Rev was Mnonitored by[r] ... See full document
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