[PDF] Top 20 The role of insulin receptor substrate 2 in hypothalamic and β cell function
Has 10000 "The role of insulin receptor substrate 2 in hypothalamic and β cell function" found on our website. Below are the top 20 most common "The role of insulin receptor substrate 2 in hypothalamic and β cell function".
The role of insulin receptor substrate 2 in hypothalamic and β cell function
... For insulin staining, sections were incubated with blocking solution con- taining PBS buffer with 5% normal chicken serum and 2% BSA for 30 min- utes, and mouse anti-insulin antibody (clone K36aC10; ... See full document
12
erbB3 recruitment of insulin receptor substrate 1 modulates insulin like growth factor receptor signalling in oestrogen receptor positive breast cancer cell lines
... MCF-7 cell line ...cancer cell models impli- cating a role for erbB receptors in resistance to IGF-IR blockade, with Haluska and colleagues [47] showing that EGFR/erbB2 signalling can confer ... See full document
17
Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population
... a 2-h 75 g oral glucose tolerance test (OGTT) with measurement of plasma glucose, insulin, and FFA concentrations at 0 min and 120 min after glu- cose ... See full document
8
Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... important role in the initiation and progression of human prostate cancer and is elevated in both epithelial and stromal tumor ...latter cell line was stimulated with varying doses of ... See full document
14
Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin secretion and by insulin resistance of the major target tissues ...particular, insulin resistance of the skeletal muscle appears to play a pivotal role in the pathogenesis of the ... See full document
8
Expression and function of the insulin receptor substrate proteins in cancer
... proteins function as essential signaling intermedi- ates downstream of many cell surface receptors that have been implicated in ...the Insulin-Like Growth Factor-1 (IGF-1) receptor (IGF-1R) ... See full document
15
The role of c-Kit and insulin receptor tyrosine kinases in beta cell function and insulin secretion
... first-phase insulin secretion and the reduction in beta cell mass and functional transcription factors previously reported in the βIRKO model ...beta cell IR during the second transition of murine ... See full document
231
Level of Fasting C Peptide as a Predictor of β Cell Function in Sudanese Patients with Type 2 Diabetes Mellitus
... function suggests the role of hyperglycemia in the insulin se- cretory ...and insulin secretory capacity ...with insulin, not as insulin that rapidly degraded in the liv- er, it ... See full document
9
Role of Vitamin D3 in Manifestations of Endocrinological Disorders
... pancreatic β-cell function, decrease insulin resistance, and improve systemic ...pancreatic β - cells by binding β-cell vitamin D receptor to produce insulin ... See full document
7
Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes
... peripheral insulin resistance is difficult to ...(15–17). Insulin, leptin, and adiponectin are important peripheral signals that inform the brain of short- and long-term nutrient availability ...of ... See full document
10
Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
... AMPA receptor function is unlikely to be changed ...NMDA receptor activation is ...AMPA receptor function in ...AMPA receptor subunit GluR1 between genotypes ...NMDA ... See full document
13
Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice
... a role in insulin resistance in β2KO ...of insulin signaling in both retinal endothelial cells (REC) [8] and Müller cells [20] grown in a high glucose concentration, leading to increased ...mediate ... See full document
6
Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
... in β-cell function associated with ...on β-cell dedifferen- tiation using mouse models, and how this may be pre- vented or reversed, and on the extent to which other islet cells can be ... See full document
7
Androgen receptor CAG repeat polymorphism is not associated with insulin resistance and diabetes among South Asian males
... Results: Sample size was 100 (response rate—90.9%, cases—53). Mean age was 49.6 ± 10.7 years. CAG repeat length did not show any significant correlation with IR or β-cell function. In all males there ... See full document
6
Download Download PDF
... catenin, insulin (IN)/insulin-like growth factor 1 (IGF-1)/ insulin receptor substrate 1 (IRS1)/phosphatidylinositol-3-ki- nase (PI3K)/protein kinase B (Akt), and IN/IGF-1/IRS1/ ... See full document
8
Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
... that insulin receptor substrate 2 (Irs2) KO mice develop diabetes associated with hepatic insulin resistance, lack of compensatory β cell hyperplasia, and leptin ...in ... See full document
12
Altered function of insulin receptor substrate 1–deficient mouse islets and cultured β cell lines
... in insulin content consistent with an important role for IRS-1 in the regulation of insulin stores in the β ...lower insulin content and a lower secretory response to glucose and gly- ... See full document
8
B lymphocytes protect islet β cells in diabetes-prone NOD mice treated with imatinib
... to β cell health through priming of T lymphocytes to mediate β cell death (14–18, ...of insulin C-peptide in patients with new-onset disease, but unfortunately disease progression ... See full document
13
Upregulation of insulin receptor substrate 2 in pancreatic β cells prevents diabetes
... or insulin secretion (mature onset diabetes of youth, or MODY), autoimmune-mediated β cell destruction (type 1), or insufficient compensation for peripheral insulin resistance (type 2) ... See full document
13
Role of the forkhead protein FoxO1 in β cell compensation to insulin resistance
... defective β cell function and altered β cell ...regulating β cell mass and its adaptation to insulin resistance are ...compensatory β cell hyperplasia ... See full document
9
Related subjects