[PDF] Top 20 Sequence and drug susceptibility of subtype C reverse transcriptase from human immunodeficiency virus type 1 seroconverters in Zimbabwe.
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Sequence and drug susceptibility of subtype C reverse transcriptase from human immunodeficiency virus type 1 seroconverters in Zimbabwe.
... (Table 1), Taq polymerase, and dye-labelled dideoxy terminators (Applied Biosystems, ...The sequence between codons 26 to 245 of the RT gene was examined. HIV-1 env heteroduplex mobility assay ...DNA ... See full document
8
Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... with drug resistance muta- tions, the effects of drug-resistant mutants and combined drugs on HIV-1 mutation frequencies were ...in susceptibility to all NNRTIs ...the virus mutation ... See full document
13
Augmentation of Human Immunodeficiency Virus Type 1 Subtype E (CRF01_AE) Multiple-Drug Resistance by Insertion of a Foreign 11-Amino-Acid Fragment into the Reverse Transcriptase
... PCR from NH3 blood specimens collected before and after chemotherapy and se- ...before drug admin- istration ...plasma virus clones (99JP-NH3-II ...insertion sequence were found, while length ... See full document
10
Worldwide Evaluation of DNA Sequencing Approaches for Identification of Drug Resistance Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... of sequence analysis approaches for the identification of drug resistance mutations in the HIV-1 RT ...viral drug susceptibility, and the fact that biological drug ... See full document
6
Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility.
... in human immunodeficiency virus (HIV) infection to delay the development of AIDS and to increase survival of patients with AIDS (4, 9, ...HIV type 1 (HIV-1) reverse ... See full document
5
High Sequence Conservation of Human Immunodeficiency Virus Type 1 Reverse Transcriptase under Drug Pressure despite the Continuous Appearance of Mutations
... The sequence of the first 320 aa of HIV-1 RT of clade B consensus (shown as a reference) is colored according to the degree of conservation observed in different ...B, C, D, F1, F2, G, H, J, and K) ... See full document
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Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1
... of human immunodeficiency virus type 1 ...whether subtype di- versity may affect responsiveness to therapy, and in general, the same treatment recommendations are applied to ... See full document
5
Amino Acid Substitutions at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Increase Susceptibility to Delavirdine and Impair Virus Replication
... Phenotypic drug susceptibility testing. Drug susceptibility was measured by using recombinant viruses and a rapid single replication cycle assay as previously described ...region from ... See full document
12
Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... the sequence of WT RT shows that there are a number of sites where PR might be expected to cleave if it had access (7, 27); moreover, the mutations in the thumb that increased the susceptibility of RT to PR ... See full document
9
A Mutation in the 3′ Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Y318F) Associated with Nonnucleoside Reverse Transcriptase Inhibitor Resistance
... decreased drug susceptibility, mutations in the RT-coding region were generated by site-directed mutagenesis of a wild-type HXB2-D EcoRI-PstI restriction enzyme fragment encompassing the HIV-1 ... See full document
5
Genetic Diversity of Protease and Reverse Transcriptase Sequences in Non Subtype B Human Immunodeficiency Virus Type 1 Strains: Evidence of Many Minor Drug Resistance Mutations in Treatment Naive Patients
... (mainly subtype B strains) had no minor ...determined from our data are significantly higher than those from previous studies with subtype B isolates (10, 24, 37, ...vitro ... See full document
7
Effect of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Polymorphism Leu-214 on Replication Capacity and Drug Susceptibility
... Molecular modeling studies. In order to test whether the structural proximity of the side chains at positions 214 and 215 could explain the different levels of viral replication and sus- ceptibility to ZDV, we built ... See full document
6
Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
... cloned virus is due to the RT mutation and not to an effect of the vector ...Leu74Val virus, the replication kinetics of uncharacterized clinical iso- lates should be interpreted with caution due to the ... See full document
7
Human Immunodeficiency Virus Type 1 Subtype F Reverse Transcriptase Sequence and Drug Susceptibility
... sensus sequence has been described as occurring in consensus sequences of subtype ...The sequence T173-K174 has been described for the IBNG subtype A/G isolate ...in subtype F strains, ... See full document
5
Infectious Simian/Human Immunodeficiency Virus with Human Immunodeficiency Virus Type 1 Subtype C from an African Isolate: Rhesus Macaque Model
... A subtype B env-based SHIV molecular clone desig- nated ...the subtype C ...ally. Sequence analysis of five clones of the env/nef amplicons revealed a 144-bp deletion in the HIV-1 env ... See full document
9
Combination of Drugs and Drug-Resistant Reverse Transcriptase Results in a Multiplicative Increase of Human Immunodeficiency Virus Type 1 Mutant Frequencies
... Table 1 shows that AZT/3TC dual treatment during HIV-1 replica- tion with wt RT increased the odds of virus mutants 9-fold compared to that of virus replication in the absence of drug, ... See full document
7
Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
... 4887 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Human immunodeficiency virus type 1 HIV-1-specific pyridinone reverse transcriptase RT inhibitors prevent HIV-1 rep[r] ... See full document
6
Selective Excision of AZTMP by Drug-Resistant Human Immunodeficiency Virus Reverse Transcriptase
... result from primer which did not get blocked by an AZT residue or from a low level of deblocking by the enzyme using the dNTPs as the pyrophosphate donor or a combination of both ... See full document
11
Characterization of V3 Sequence Heterogeneity in Subtype C Human Immunodeficiency Virus Type 1 Isolates from Malawi: Underrepresentation of X4 Variants
... obtained from the Los Alamos HIV-1 database (44). A total of 33 subtype C and 69 subtype B sequences were ...used. Subtype B sequences were classified into two groups, either ... See full document
11
Cross-Linking of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Template-Primer
... these drug resistance mutations manifest themselves via direct inter- actions with the dNTP rather than indirectly through the DNA ...competition from other components in the reaction ... See full document
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