[PDF] Top 20 Sequences in pol Are Required for Transfer of Human Foamy Virus-Based Vectors
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Sequences in pol Are Required for Transfer of Human Foamy Virus-Based Vectors
... env sequences which are required to produce vectors based on HIV-1 have been described, although subse- quent investigations could not define a specific sequence (7, 22, ...direct-repeat ... See full document
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RNA and Protein Requirements for Incorporation of the Pol Protein into Foamy Virus Particles
... subgenomic pol transcript and the (pre)genomic ...also required for the discrimination of both RNAs (14, 22, ...those sequences that, in addition to the LTRs and adjacent sequences, are ... See full document
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Characterization of a cis-Acting Sequence in the pol Region Required To Transfer Human Foamy Virus Vectors
... helper virus, by a Tas expression plasmid (18, 45), or by a stable Tas-expressing cell line ...HFV vectors which are independent of Tas, we generated an expression plasmid (pMH4) ...to virus which is ... See full document
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Improved Primate Foamy Virus Vectors and Packaging Constructs
... gene transfer using vectors derived from foamy viruses (FVs) (19, ...accidental human in- fection, is a major feature that makes FVs attractive candidates for the development of a retroviral ... See full document
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Novel Tat-Encoding Bicistronic Human Immunodeficiency Virus Type 1-Based Gene Transfer Vectors for High-Level Transgene Expression
... gene transfer vectors ...gene transfer vectors were derivatives of the molecular clone pNL4-3 (GenBank accession ...sarcoma virus (HaMSV) and EMCV, ...gene transfer ... See full document
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The Roles of Pol and Env in the Assembly Pathway of Human Foamy Virus
... Human foamy virus (HFV) is the prototype of the Spuma- virus genus of the Retroviridae family ...a human cancer patient (1), but, based on homology with other primate isolates, ... See full document
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Isolation of novel human endogenous retrovirus-like elements with foamy virus-related pol sequence.
... tumor virus (39) retroviral sequence, which has been identified as a dUTPase on the basis of both sequence simi- larity to the dUTPase family (36) and enzymatic activity (1, ...these sequences are related. ... See full document
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Foamy Retrovirus Integrase Contains a Pol Dimerization Domain Required for Protease Activation
... domain required for PR activity. To test the possibility that IN sequences missing in the 120st mutant facilitate Pol dimerization, enhancing PR activity, we introduced a leucine zipper (zip) ... See full document
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Foamy Virus Pol Protein Expressed as a Gag-Pol Fusion Retains Enzymatic Activities, Allowing for Infectious Virus Production
... he foamy virus (FV) genome encodes the three major viral proteins Gag, Pol, and Env that are common to all other ret- roviruses, in addition to two regulatory proteins, Bet and ...of Pol ... See full document
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Evidence that the Human Foamy Virus Genome Is DNA
... Human foamy virus (HFV) is the prototype virus of the Spumavirus genus of ...a human virus because the first isolation was from a human cancer-derived cell line (1); ... See full document
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Efficient encapsidation of human immunodeficiency virus type 1 vectors and further characterization of cis elements required for encapsidation.
... of sequences at the 5 * end of HIV-1 RNA for ...that sequences upstream of SL1, SL3, and SL4, are also required for encapsidation (35, ...protein. Based on a progressive comparison of probable ... See full document
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Foamy virus vectors.
... the human placental alkaline phos- phatase gene under the control of the MLV LTR promoter to make the vector constructs pFGPSN and pFGPMAP, respec- tively ...promoter required for high-level expression of ... See full document
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The R Region Found in the Human Foamy Virus Long Terminal Repeat Is Critical for both Gag and Pol Protein Expression
... necrosis virus (SNV), a retrovirus that is fairly closely related to murine leukemia virus, produced a somewhat different ...manner. Based on these data, as well as subsequent work examining the ... See full document
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Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer.
... Sindbis virus genomic 49S RNA serves as the template for synthesis of a complementary neg- ative strand by the virus-encoded ...alphavirus vectors is based on the same strategy as expression ... See full document
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The human foamy virus pol gene is expressed as a Pro-Pol polyprotein and not as a Gag-Pol fusion protein.
... the human foamy virus (HFV) Pol polyprotein of 120 kDa is synthesized in the absence of the active HFV aspartic ...HFV pol expression and ...be required for translational ... See full document
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Identification of a Conserved Residue of Foamy Virus Gag Required for Intracellular Capsid Assembly
... B virus, foamy viruses (FV) require expression of the envelope protein for budding of intracellular capsids from the cell, suggesting a specific interaction between the Gag and Env ...simian foamy ... See full document
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Human endogenous retroviruslike genome with type C pol sequences and gag sequences related to human T-cell lymphotropic viruses.
... Comparison of the RTVL-H2 amino acid segment with the Moloney murine leukemia virus MLV p30 sequence 31 and the equivalent region in a type C human endogenous retroviral element, termed [r] ... See full document
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In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissues.
... cDNA sequences from CSF, plasma, and individual tissues, but we were successful only in one of four subjects from whom DNA sequence information was ...cDNA sequences were obtainable, we found a general ... See full document
13
Orthoretroviral like prototype foamy virus gag pol expression is compatible with viral replication
... The phenotype of the in-frame GP4 fusion construct was special since it was the only one examined in the proviral and vector system context that did not allow production of infectious PFV particles. The only differ- ence ... See full document
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Contribution of the gag and pol sequences to the leukemogenicity of Friend murine leukemia virus.
... To determine whether the F-MuLV gag and pol genes also possess sequences that affect leukemogenicity, we generated recombinant viruses between the F-MuLV gag and pol genes and two other [r] ... See full document
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