[PDF] Top 20 Sequential S232/S235/S238 Phosphorylation of the Hepatitis C Virus Nonstructural Protein 5A
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Sequential S232/S235/S238 Phosphorylation of the Hepatitis C Virus Nonstructural Protein 5A
... the protein concentrations were quantified. In general, 20 g of protein was separated by SDS-PAGE before the protein was transferred to a nitrocellulose membrane for blocking and subsequent detection ... See full document
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Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A.
... 56-kDa protein (p56) and a 58-kDa protein (p58), are produced from the hepatitis C virus (HCV) nonstructural region 5A ...NS4A protein. To clarify the nature of ... See full document
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Nonstructural Protein 5A of Hepatitis C Virus Inhibits the Function of Karyopherin β3
... the protein secretion-enhancing activity of karyopherin 3, as was shown by overexpression of PSE1 in yeast cells ...to virus infection, from HCV-infected cells, thus preventing the initiation of antiviral ... See full document
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Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry
... cells. Protein interaction between Pim1 and NS5A is mediated by domain I of NS5A and aa 141 to 180 of ...gated protein interaction in a dose-dependent manner, implying that kinase activity of Pim ... See full document
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Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles
... core protein, pre- sumably around ...NS5A-core protein interaction results in disruption of virus production at an early stage of virion ...core protein via interaction with domain III of NS5A ... See full document
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Efficient Rescue of Hepatitis C Virus RNA Replication by trans-Complementation with Nonstructural Protein 5A
... In view of a model for trans-complementation, three possi- bilities can be envisaged. In the first model, expression of functional NS5A may confer an increased permissiveness to the host cell, for instance, by ... See full document
Mutational Analysis of Hepatitis C Virus Nonstructural Protein 5A: Potential Role of Differential Phosphorylation in RNA Replication and Identification of a Genetically Flexible Domain
... 2004 Nonstructural protein 5A of the hepatitis C virus (HCV) is a highly phosphorylated molecule implicated in multiple interactions with the host cell and most likely involved ... See full document
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Characterization of a Threonine-Rich Cluster in Hepatitis C Virus Nonstructural Protein 5A and Its Contribution to Hyperphosphorylation
... Germany c Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany ABSTRACT Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a ... See full document
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Nonstructural Protein 5A Impairs DNA Damage Repair: Implications for Hepatitis C Virus-Mediated Hepatocarcinogenesis
... of Hepatitis C Virus, Hallym University, Anyang, South Korea b Ilsong Institute of Life Science, Hallym University, Anyang, South Korea c Korea National Institute of Health, Cheongwon-gun, ... See full document
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Conserved Determinants for Membrane Association of Nonstructural Protein 5A from Hepatitis C Virus and Related Viruses
... The observation that very similar membrane anchor do- mains with highly ordered structures can be found in these related viruses strongly supports the hypothesis that these pro- tein domains share a common function that ... See full document
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Inhibition of Intrahepatic Gamma Interferon Production by Hepatitis C Virus Nonstructural Protein 5A in Transgenic Mice
... cleared virus within 1 to 2 ...and protein levels in NS5A-Tg mice, and an inverse expression of transcription factors Gata-3 and Tbx21 is ...and protein expression were elevated in both NS5A-Tg and ... See full document
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Regulation of Hepatitis C Virus Replication by Nuclear Translocation of Nonstructural 5A Protein and Transcriptional Activation of Host Genes
... We first studied the effects of a pan-caspase inhibitor or a mu- tation in the putative N-terminal caspase cleavage site on NS5A translocation to the nucleus. Pan-caspase inhibition partially in- hibited NS5A ... See full document
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A Conserved Tandem Cyclophilin-Binding Site in Hepatitis C Virus Nonstructural Protein 5A Regulates Alisporivir Susceptibility
... Nonstructural Protein 5A Regulates Alisporivir Susceptibility Henry Grisé, a Stephen Frausto, a Timothy Logan, b,c and Hengli Tang a Department of Biological Science, a Department of Chemistry ... See full document
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Hepatitis C Virus Nonstructural Protein 5A: Biochemical Characterization of a Novel Structural Class of RNA-Binding Proteins
... the C-4 carbonyl of the uracil base and, by inference, the C-6 carbonyl of the guanine base interact with ...the protein includes the amino-terminal domain I as well as the subsequent linker that ... See full document
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Hepatitis C Virus Nonstructural 5A Protein and Interferon Resistance: a New Model for Testing the Reliability of Mutational Analyses
... The clinical and biochemical characteristics of patients are expressed as the mean ⫾ the standard deviation or median and range as appropriate. RESULTS NS5A amino acid sequences. The complete NS5A region of HCV ... See full document
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Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling
... NS5A protein, a master regulator of HCV replica- tion and assembly, has been found to colocalize with apolipoprotein A1 around the lipid droplets of steatotic hepatocytes ...NS5A protein, under the control ... See full document
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Nonstructural Protein 5A (NS5A) and Human Replication Protein A Increase the Processivity of Hepatitis C Virus NS5B Polymerase Activity In Vitro
... HCV nonstructural proteins or host factors as part of a replication complex in vivo, and these additional factors are needed to ensure the functionality of HCV helicase and efficient replication of HCV in cells ... See full document
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Insertion of Green Fluorescent Protein into Nonstructural Protein 5A Allows Direct Visualization of Functional Hepatitis C Virus Replication Complexes
... 2004 Hepatitis C virus (HCV) replicates its genome in a membrane-associated replication complex, composed of viral proteins, replicating RNA and altered cellular ...of nonstructural ... See full document
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Nonstructural 5A Protein of Hepatitis C Virus Regulates Soluble Resistance-Related Calcium-Binding Protein Activity for Viral Propagation
... core protein was protected by cellular sorcin and thereby that sorcin played a cru- cial role in the envelopment of the viral core protein into mem- ...a phosphorylation-defective sor- cin mutant was ... See full document
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Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
... Confocal laser scanning microscopy. Nonconfluent Huh-7 cells grown as monolayers on plastic coverslips were infected at an MOI of 75 with the recom- binant adenovirus AdIV1043 or AdIV1053. At 65 h postinfection, cells ... See full document
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