[PDF] Top 20 Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
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Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... certain ribosomal proteins or the intact translational machinery to inhibit ...of ribosomal pro- teins and activation of ...the ribosomal protein S3a has been found to be directly related to ... See full document
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Construction of a Herpes Simplex Virus Type 1 Mutant with Only a Three-Nucleotide Change in the Branchpoint Region of the Latency-Associated Transcript (LAT) and the Stability of Its Two-Kilobase LAT Intron
... the 2-kb LAT has been shown to down-regulate productive infections in sensory neurons and suppress viral replication (12, 22, 39), thus pro- moting the establishment of latent infection in these neurons (43, 56, ... See full document
10
The Stable 2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1 Can Alter the Assembly of the 60S Ribosomal Subunit and Is Exported from Nucleus to Cytoplasm by a CRM1-Dependent Pathway
... the 2-kb LAT intron affect ribosome assembly or trans- lation? It is known that in the absence of sufficient numbers of functional 60S subunits to pair with, 40S ribosomal subunits will accumulate in ... See full document
7
Analysis of Protein Expression from within the Region Encoding the 2.0-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1
... LAT-GFP virus during either productive or latent ...recombinant virus, vLAT-GFP, was produced by cotransfection of the plasmid p⌬CMV(H)GFP and parental F strain DNA, followed by several rounds of plaque ... See full document
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The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... HSV-2 latency and the factors that induce reactivation have been the subjects of extended ...in latency. The gene encoding these latency-associated transcripts (LATs) (5, 22) is ... See full document
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Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structure.
... with herpes simplex virus type 1 (HSV-1), the only transcripts detected by Northern blot or in situ hybridization are the latency-associated transcripts (LATs) (9, ... See full document
5
Selection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcript.
... Mutant virus TB1 does not display any phenotypic difference from its parental strain (HFEM) as far as growth or reactiva- tion kinetics are concerned ...of splicing between exons 1 and 2 do ... See full document
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Identification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT): translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT.
... i The nearest consensus promoter is located almost 700 nucleotides upstream of the 5' end of the 2.0-kb LAT 2, 67, ii HSV-1 mutants lacking this putative promoter do not express the LATs[r] ... See full document
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Genetic Studies Exposing the Splicing Events Involved in Herpes Simplex Virus Type 1 Latency-Associated Transcript Production during Lytic and Latent Infection
... excised intron from exonucleolytic deg- radation, which would suggest that the hairpin exists when the intron is released, presumably as a ...of 2-kb LAT to linearization by debranching extract (46, ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... marker-rescued virus dLAT2903R, dLAT371 and its marker-rescued virus dLAT371R, and ...LAT transcript(s) made by each virus are detailed in ...LAT transcript in the wild- type and ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... erty associated with a number of cellular transcriptional en- hancers (18), and it is important to note that enhancer activi- ties have previously been associated with the region of LAT containing the 5 ⬘ ... See full document
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The Stable 2.0-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Does Not Function as an Antisense Repressor of ICP0 in Nonneuronal Cells
... LAT intron from the cis-acting properties of the LAT ...LAT intron at various levels, similar to those found during lytic ...wild-type virus and examination of ICP0 expression at time points ... See full document
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Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... viral proteins on viral pathogenesis in the initial absence of other viral functions ...HSV-1 intron under the control of a constitutive promoter (cytomegalovirus [CMV]) and was used to examine the ... See full document
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The 2-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Has a Half-Life of Approximately 24 Hours in SY5Y and COS-1 Cells
... unstable transcript, such as IL-2, and increase its stability and thus its expression levels when expressed from within the LAT ...the 2-kb LAT intron did not serve as an mRNA in vitro for ... See full document
9
The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... Herpes simplex virus type 1 (HSV-1) is neurotropic virus capable of forming latent infections for the lifetime of an ...During latency, transcription is restricted ... See full document
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CTCF-Dependent Chromatin Boundary Element between the Latency-Associated Transcript and ICP0 Promoters in the Herpes Simplex Virus Type 1 Genome
... LAT intron DNA for potential CTCF binding ...(Fig. 1) (30). To test if these repeats interact with CTCF proteins, we conducted EMSA with Drosophila and human ...(lanes 2, ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... cells 2 h postinfection during the lytic phase of infection ...during latency, since we observe a large num- ber of apoptotic neurons in 17 N/H-infected trigeminal ganglia and none in 17 ⫹ -infected ... See full document
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Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... HSV-1 latency and the HSV-1 reactivation ...influences latency, reactivation, and survival of gangli- on-resident T ...HSV-1 latency and reactivation significantly ...in ... See full document
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A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
... Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.. Expression of her[r] ... See full document
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Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1.
... By using various fragments and deletion constructs, this promoter activity 3269 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To identify promoter regions which contr[r] ... See full document
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