[PDF] Top 20 The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript.
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The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript.
... in 1 ml of lysis buffer (a ...55 8 C for 1 h, and revortexed, and debris was removed by microcentrifugation for 2 ...4 8 C for 15 min, and centrifuged for 15 min at 4 8 C, and the ... See full document
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Two Small RNAs Encoded within the First 1.5 Kilobases of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Can Inhibit Productive Infection and Cooperate To Inhibit Apoptosis
... of LAT sRNA in TG and cultured cells. A pre- vious study identified two LAT sRNAs within the first ...of LAT coding sequences ...a LAT null mutant that lacks the first 1.5 ... See full document
9
Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype
... The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for the high spontaneous and induced reactivation ... See full document
6
A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... LR gene of BHV-1 is clearly the homologue of the HSV-1 LAT gene, there are some important ...the primary LAT transcript is 8.3 kb (45), whereas the primary ... See full document
12
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... FIG. 1. Structure of LAT-EGFP and ⌬LAT-EGFP ...the virus (TRL, terminal repeat long; IRL, internal repeat long; IRS, internal repeat short; TRS, terminal repeat short) that bound the unique ... See full document
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Construction of a Herpes Simplex Virus Type 1 Mutant with Only a Three-Nucleotide Change in the Branchpoint Region of the Latency-Associated Transcript (LAT) and the Stability of Its Two-Kilobase LAT Intron
... 64), reactivation (5, 8, 25, 37, 45), or neuronal survival (46, 65), as summarized ...below. First, the 2-kb LAT has been shown to down-regulate productive infections in sensory neurons ... See full document
10
A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse
... latency-associated transcript (LAT) is essential for the wild-type herpes simplex virus type 1 (HSV-1) high-reactivation phenotype since LAT ⴚ ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... for LAT function when LAT is not in its normal ...of LAT from ...otherwise-complete LAT gene, but it is needed when only the first ...of LAT is ...the first ... See full document
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The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation.
... the LAT gene that is colinear with ICP34.5 (kb 6.2 to 7.1 of LAT) is involved in spontaneous reactivation of herpes simplex virus type ...ICP34.5 gene ... See full document
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A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1.
... ICP34.5 gene, which overlaps LAT nt 6200 to 7100, reduces spontaneous reactivation (19), wild-type reactivation can be restored by insertion of the ...ICP34.5 gene at a ... See full document
5
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... HSV-1 LAT gene and replacing it with the Escherichia coli b-galactosidase gene (b-Gal) and simian virus 40 (SV40) polyadenylation sequences derived from PCH110 (See ...Fig. 1). ... See full document
9
Role for Gamma Interferon in Control of Herpes Simplex Virus Type 1 Reactivation
... Conclusions. Spontaneous HSV-1 reactivation leading to detectable virus in ganglia was not seen in GKO and RGKO ...of reactivation in the IFN-g-incompetent mice, as detected by assay of ... See full document
6
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... Viral gene transcription in the region of the ...the LAT null mutants. The 1.9-kb deletion in the LAT null mutants should not adversely affect the expression of any known HSV-1 genes other ... See full document
16
In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-base-pair region located between the promoter and the 5' end of the 2.0 kilobase latency-associated transcript.
... duced reactivation following epinephrine iontophoresis, the TG from these rabbits reactivated with wild-type kinetics in explant ...vivo reactivation in rabbits and in vitro reactivation in ... See full document
5
The Stable 2.0-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Does Not Function as an Antisense Repressor of ICP0 in Nonneuronal Cells
... 2.0-kb LAT intron from the cis-acting properties of the LAT locus. First, we generated multiple cul- tured 293T cell lines and populations stably expressing the nuclear ...2.0-kb LAT intron at ... See full document
15
Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... Since LAT can protect cells from a host of apoptotic inducers, it is thought that LAT may affect a downstream regulator of apoptosis ...Alternatively, LAT may interact with certain ribosomal proteins ... See full document
11
In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.
... From studies of HSV-1 LAT+ and LAT- viruses in the rabbit model using both in vitro and in vivo reactivation techniques, the data support and extend previous conclusions that i LAT expre[r] ... See full document
5
The 2-Kilobase Intron of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Has a Half-Life of Approximately 24 Hours in SY5Y and COS-1 Cells
... for gene therapy ...therapeutic gene that has a normally unstable transcript, such as IL-2, and increase its stability and thus its expression levels when expressed from within the LAT ... See full document
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The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... induce reactivation have been the subjects of extended ...80 gene products expressed by the 150-kb HSV-2 genome during acute infection, only one family of transcripts is readily detected in ...The ... See full document
7
Deacetylation of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer and a Decrease in LAT Abundance Precede an Increase in ICP0 Transcriptional Permissiveness at Early Times Postexplant
... the LAT may act to suppress imme- diate-early genes and that the chromatin status of the LAT enhancer is linked to early reactivation ...the LAT promoter and/or 5 ⬘ exon mutants showed ... See full document
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