[PDF] Top 20 Stability of Large Segmental Duplications in the Yeast Genome

... meiotic stability of large direct tandem duplications, the three strains YKF1050, -1038, and -1057 carrying intrachromosomally duplicated blocks of 41, 115, and 213 kb, respectively, were crossed ... See full document

... fission yeast, indicating that both rearrangements and CNVs may be gained or lost at rates in excess of point ...of duplications has been observed in laboratory cultures of ...spontaneous duplications ... See full document

... both duplications and other types of muta- tions - such as inversions - often result in similarity measures that cannot be computed ...of duplications: large segmental duplications ... See full document

... the genome could also alter our interpretation of genetic maps and haplotypes, especially at high ...in genome structure may be important for comparative genomic studies, for analysis of recombination in ... See full document

... At the chromosome level, breakage-fusion-bridge (BFB) cycles are likely an underlying mechanism of ERBB2 amplification for at least a subset of breast tumors, as (a) the ERBB2 amplicons predominantly reside within a ... See full document

... a segmental duplication of a large telomeric chromosome ...this segmental genome duplication event(s) is difficult to reconstruct, as it is overlaid by numerous local cis-duplication events ... See full document

... complete genome sequences has Although whole-genome duplications would seem to revealed that many organisms contain a large num- be an efficient mechanism for evolving new genes, the ber of ... See full document

... in large databases is used to get insight into the function of nonannotated genomic ...and segmental duplications, we show analytically and computationally that paralogous and orthologous gene pairs ... See full document

... and genome-wide ...of large deletions or single-base deletions and substitutions (Bruggemann et ...both large deletions and segmental duplications generated within the FN mutant ... See full document

... subtelomeric segmental duplications ('subtelomeric repeats') comprise about 25% of the most distal 500 kb and 80% of the most distal 100 kb in human DNA ...islands; large and highly similar ... See full document

... In Drosophila, the homeotic genes are responsible for specify- ing the diversity of segments. Most of the homeotic genes are found in two clusters, the Antennapedia Complex (ANT-C) and the Bithorax Complex (BX-C). The ... See full document

... • The phosphoprotein-binding 14-3-3 proteins interact with hundreds of (phosphorylated) ohnologue proteins in mammalian cells, suggesting that regulated phosphorylation of 14-3-3 docking sites provides a ... See full document

... caudatum genome was aligned with each of the three previously sequenced aurelia genomes using a modified ver- sion of the method used to align ...aurelia genome identified best reciprocal hits (RBHs) between ... See full document

... ABSTRACT Gene duplication and loss are major sources of genetic polymorphism in populations, and are important forces shaping the evolution of genome content and organization. We have reconstructed the origin and ... See full document

... diverse yeast, in con- trast to the well-conserved downstream region (see Figure S2 in Additional file ...multiple genome sequences from related species, an increase in false positive results may not ... See full document

... whole genome sequencing mutation accumulation experiment were diploids descended from D |(-2)|-7B-YUNI300 (Pavlov et ...reference yeast strain, while YJM789 is a diverged background derived from a clinical ... See full document

... relative stability of the oxo and thio derivatives of hydantoin are rather similar to those reported in the literature for uracil and its thio derivatives, oxazolidine, thiazolidine and ... See full document

... extensive genome-wide ChIP-seq mapping of histone PTMs and principal component analysis revealed that many histone modifications correlate with similar affects, which suggests that a possible histone code would be ... See full document

... A set of Y-autosome translocations with appropriately positioned break- points, therefore, can in principle be used to generate a non-overlapping set of deficiencies and du[r] ... See full document

... C. dubliniensis yeast cells express Tlo1 at a level comparable to other Mediator subunits. However, expression of Tlo2 is far lower [3]. Deletion of TLO1 appeared to have stronger ef- fects on filamentous growth ... See full document