[PDF] Top 20 Structural Analysis of Human Immunodeficiency Virus Type 1 CRF01_AE Protease in Complex with the Substrate p1-p6
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Structural Analysis of Human Immunodeficiency Virus Type 1 CRF01_AE Protease in Complex with the Substrate p1-p6
... for substrate binding, and the flap hinge and core regions play key roles in flap dynamics (17, 19, ...the CRF01_AE protease structure is likely to restrict flexi- bility and thereby affect flap ... See full document
5
Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor
... the virus becomes resistant to the ...mutations, substrate binding may also be ...of substrate sites would be required for the virus to ...V82A protease drug-resistant mutation (14, 21, ... See full document
10
Structural Basis for Coevolution of a Human Immunodeficiency Virus Type 1 Nucleocapsid-p1 Cleavage Site with a V82A Drug-Resistant Mutation in Viral Protease
... the substrate residues P2 to P2 ⬘ (GlnP3 is disordered in both complexes and GlyP3 has no side chain) reveals several rearrangements in packing between the two ...the protease mutation, packing between ... See full document
9
Importance of Protease Cleavage Sites within and Flanking Human Immunodeficiency Virus Type 1 Transframe Protein p6* for Spatiotemporal Regulation of Protease Activation
... of p6* in the context of an infectious provirus appears challenging, as parts of the pol reading frame are superimposed by cis-active RNA frameshift signals and func- tional Gag protein ...of p6* appeared ... See full document
12
Molecular Basis for the Relative Substrate Specificity of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Proteases
... the substrate at a much greater rate than does FIV ...at P1 ⴕ , FIV PR cleaves the substrate at a much higher rate than does HIV-1 ...the P1 position, in combination with an appropriate ... See full document
12
Functional Correlation between a Novel Amino Acid Insertion at Codon 19 in the Protease of Human Immunodeficiency Virus Type 1 and Polymorphism in the p1/p6 Gag Cleavage Site in Drug Resistance and Replication Fitness
... sequence analysis revealed the presence of a variant of human immunodeficiency virus type 1 (HIV-1) containing an insertion of amino acid Ile in the protease gene ... See full document
10
Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors.
... against human immunodeficiency virus type ...to protease inhibitors can develop and is attributed to the appearance of mutations in the protease ...the substrate analog ... See full document
8
Replacement of the P1 Amino Acid of Human Immunodeficiency Virus Type 1 Gag Processing Sites Can Inhibit or Enhance the Rate of Cleavage by the Viral Protease
... sarcoma virus NC/PR cleavage site (PAVS/LAM). They noted that a P1 Trp or a P1 Leu improved the activity of a substrate with a P1⬘ Ala beyond what was expected and suggested that the ... See full document
8
In Vitro Assembly Properties of Human Immunodeficiency Virus Type 1 Gag Protein Lacking the p6 Domain
... of virus particles occurs through the organized multimerization of numerous protein subunits, although in some cases nucleic acid is also required (for a review, see reference ...as human immunodefi- ciency ... See full document
10
Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights for Better Antiviral Therapy
... of protease inhibitor therapy, patients infected with human immunodeficiency virus (HIV) often develop drug-resistant HIV ...the protease, particularly in patients receiving indinavir ... See full document
10
Mechanism of Substrate Recognition by Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variants Revealed by a Novel Structural Intermediate
... Human immunodeficiency virus type 1 (HIV-1) protease processes and cleaves the Gag and Gag-Pol polyproteins, allowing viral maturation, and therefore is an important ... See full document
10
Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease
... the protease can differentially affect cleavage site recognition and, by association, the substrate preference of the ...the protease are associated with the NC/p1 cleavage site mutation in ... See full document
10
Replicative Fitness of Protease Inhibitor-Resistant Mutants of Human Immunodeficiency Virus Type 1
... of human immunodeficiency virus type 1 (HIV-1) mutants selected by different protease inhibitors (PIs) in vivo was ...wild type (WT), NL4-3, in the absence of drugs ... See full document
9
Human Immunodeficiency Virus Type 1 Group M Protease in Cameroon: Genetic Diversity and Protease Inhibitor Mutational Features
... this analysis, a non-subtype B con- sensus sequence, which has been established by the use of 187 global PR sequences of subtypes A, C, D, A/E, F, G, and H (26), was ...This analysis revealed minimal amino ... See full document
9
Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication.
... Table 1, neither the wild-type virus nor the V32I/V82I mutant showed any decrease in infectivity when the infection was done in the presence of the PR inhibitor at concentrations between ...of ... See full document
5
Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease.
... of human immunodeficiency virus type 1 (HIV-1) and other primate lentiviruses which enhances virion infectivity by an unknown ...during virus production prevented the ... See full document
6
The Late-Domain-Containing Protein p6 Is the Predominant Phosphoprotein of Human Immunodeficiency Virus Type 1 Particles
... protein p6 is phosphorylated at multiple sites in infected cells and virions and that pp6 constitutes the major phosphoprotein of HIV-1 ...virion-associated p6 described by Ott et al. (38), phosphor- ... See full document
10
Expression of active human immunodeficiency virus type 1 protease by noninfectious chimeric virus particles.
... Attempts to detect RT in MoHIV-I and MoHIV-III cell lysates and virion particles by immunoblot analysis were consistently negative under conditions in which the protein was readily detec[r] ... See full document
8
Analysis of Human Immunodeficiency Virus Type 1 Gag Ubiquitination
... within p6 (21, 22). Since we observed that Gag domains other than p6 have the potential to be ubiquitinated, we wanted to test whether HIV-1 Gag proteins lacking lysine residues in p6 are ... See full document
11
Structural studies of human immunodeficiency virus type 1 by cryo electron tomography
... In chapter 2, I present the results of a study of mature HIV-1 virus-like particles. This project was intended to catalog the three-dimensional morphologies of viral cores in vivo, measure the cone angles ... See full document
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