[PDF] Top 20 Two-Stage Designs in Case–Control Association Analysis
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Two-Stage Designs in Case–Control Association Analysis
... first stage is to screen for those truly associated ...pooling stage. The significance level of the two-stage design for a single- marker test is taken to be a ¼ 5 3 10 8 , a level suggested ... See full document
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Two stage study designs combining genome wide association studies, tag single nucleotide polymorphisms, and exome sequencing: accuracy of genetic effect estimates
... Our mini-exome two-stage study design was different from a genome-wide two-stage study design in several ways. The sample size was small (hundreds instead of thousands of SNPs), the p-value ... See full document
7
A two-stage microbial association mapping framework with advanced FDR control
... The American Gut Project (www.americangut.org) is a crowd-sourced project aimed at creating a comprehensive map of the human microbiome. The data include 16S rRNA V4 region sequences from 8610 fecal samples using ... See full document
16
Marker selection for whole genome association studies with two stage designs using dense single nucleotide polymorphisms
... in stage two, namely, replication-based analy- sis, joint analysis assuming homogeneity between stages, and joint analysis that allows heterogeneity between stages ...in stage ... See full document
5
SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer
... few association studies have been performed on solid tumors, especially ...the association between genetic polymorphism of U2AF35/U2AF65 with PC and revealed the interaction of U2AF65 and smoking may ... See full document
8
Two stage strategies to detect gene × gene interactions in case control data
... genetic association studies based on hundreds of thousands of single-nucleotide polymorphisms (SNPs) are a popular option for the study of complex ...compare two-stage strategies for pairwise SNP ... See full document
5
Issues in Group Sequential/Adaptive Designs
... adaptive designs are used (e.g., control of the Type I error ...sequential designs, which allow early stopping for efficacy in light of compelling evidence of benefit or early stopping for futility ... See full document
110
Reporting of Human Genome Epidemiology (HuGE) association studies: An empirical assessment
... this analysis, we queried the HuGE Pub Lit database for population-based studies that used observational study designs ...(i.e., case-control, cohort, and cross-sectional studies) to ... See full document
10
Genetic variation in inflammatory and bone turnover pathways and risk of osteolytic responses to prosthetic materials
... p>0.05. Two genotype=phenotype association analyses were performed: A case=control association analysis for susceptibility loci for osteolysis, and a quantitative trait ... See full document
21
Genome wide association tests by two stage approaches with unified analysis of families and unrelated individuals
... the association test that depends on trait values and within-family geno- type ...the association test is performed on a much smaller set of selected ...several two-stage methods to test ... See full document
5
Joint analysis of case parents trio and unrelated case control designs in large scale association studies
... both case-parents trios and unrelated con- trols are ...in case-control ...the two test sta- tistics (Z TDT and Z CC ), we proposed a combined test ... See full document
5
Statistical Analysis in Two Stage Randomization Designs in Clinical Trials
... of Robins et al. (1994), Wahed and Tsiatis characterized the most efficient estima- tor for the survival distributions in the case when there is no censoring. Both the LDT and the WT estimators have relatively ... See full document
81
Genome wide association studies using an adaptive two stage analysis for a case control design
... In this study, we applied all test statistics to the GAW15 simulated data. However, the simulated effect near the peak is so strong that all test statistics were able to detect the susceptibility disease gene on ... See full document
5
Two stage family based designs for sequencing studies
... genome-wide association studies for discovering common variants associated with disease traits have been conducted using a case-control design with unrelated ...based designs [2-5]. ... See full document
5
Sample size requirements for case-control study designs
... of case-control sample sizes required for odds ratios, unadjusted or ad- justed for a confounder [1] and for stratified matched de- signs ...[4,5]. Two conversational FORTRAN programs, DAYSMITH and ... See full document
5
Software Measurement Methods: An Analysis of Two Designs
... In software engineering, software measures are often proposed without precise identification of the measurable concepts they attempt to quantify: consequently, the numbers obtained are challenging to reproduce in ... See full document
13
A Performance Analysis of Two Approximate Adaptive Designs
... adaptive control designs may scale badly with approximator dimension ...based designs and multi-resolution approximation based designs have been shown to have good scaling properties ...the ... See full document
8
Two-stage optimal designs with survival endpoint when the follow-up time is restricted
... arm two-stage optimal design by using the one-sample log-rank test with exact mean and variance estimates [17, ...first stage due to futility to protect patients when the treat- ment under ... See full document
12
Computer Aided Designs of Die and Thermal Control for Fabrication of A356 Wheels
... In Fig. 7(a), shrinkage porosity appears in the hub and runner, while in Fig. 7(b), no shrinkage porosity is observed in the hub but porosity does appear in the runner. These experimental results show that with a large ... See full document
5
Statistical inference for extended or shortened phase II studies based on Simon’s two-stage designs
... first stage [4, ...Simon’s two-stage designs [17] where the second stage sample size is decided at the end of stage 1 based on observed ...second stage sample size ... See full document
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