[PDF] Top 20 Understanding development and stem cells using single cell based analyses of gene expression
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Understanding development and stem cells using single cell based analyses of gene expression
... and stem cell ...mammalian development, have implicated regulated transcriptional heterogeneity as a contributor to the pluripotent state, and have uncovered an unexpected yet widespread pattern of ... See full document
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Characterizing heterogeneity in leukemic cells using single cell gene expression analysis
... for understanding complex biological sys- tems, including the hematopoietic system ...of single- cell data [20,25,30]. Here, we employed a co-expression network-based method (WGCNA, ... See full document
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Psychrophilic proteases dramatically reduce single cell RNA seq artifacts: a molecular atlas of kidney development
... kidney single-cell RNA- seq data generates the cell groupings shown in ...following single-cell dissociation, it is possible to assign cell types to the resulting clusters ... See full document
8
Developmental fate and lineage commitment of singled mouse blastomeres
... (PCA) based on the expression of these genes in the TE, ICM and 1/32LS ...blastomere expression patterns onto component 1 and 2 clearly separated the individual cells into three distinct ... See full document
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piRNAs and PIWI proteins: regulators of gene expression in development and stem cells
... molecular analyses have shown that Aub function in GSC biology strongly depends on its role in endogenous mRNA regulation ...represses expression of the Cbl proto-oncogene in GSCs through the binding of its ... See full document
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Single-Cell Gene Expression Variation as A Cell-Type Specific Trait: A Study of Mammalian Gene Expression Using Single-Cell RNA Sequencing
... diversity, gene expression variation indicates the presence of an assortment of cell types and ...sub-types. Single-cell RNA sequencing data may be used to identify clusters of similar ... See full document
136
Beyond comparisons of means: understanding changes in gene expression at the single cell level
... of cells (given by experimental con- ditions or cell ...for understanding a cell’s fate and ...genes based on log-fold changes (LFCs) of overall expression between the ...overall ... See full document
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Genome wide Mapping of Polycomb Target Genes Unravels Their Roles in Cell Fate Transitions
... germ cell termi- nal differentiation processes (Caretti et ...is based on the surprising observation that the PcGs, in some cases, are bound to their target genes in undifferentiated cells, despite ... See full document
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PRODUCTION OF MOUSE EMBRYONIC STEM CELLS EXPRESSING THE GPX1 AND NURR1 GENES BY USING LENTI VIRUS VECTORS; NEW CELLS SOURCES FOR CELL THERAPY IN PARKINSON'S DISEASE
... the development and progression of disease. Cell therapy as a treatment for the replacement of lost neurons can be a permanent and effective treatment for this ...by using the techniques of ... See full document
14
Comprehensive gene expression analyses in pluripotent stem cells of a planarian, Dugesia japonica
... somatic stem cells in planarians possessing pluripotency, and can give rise to all types of cells, including germline ...and expression dynamics of various pluripotent somatic stem ... See full document
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miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma
... the expression levels of CD90 and miR-589-5p were signifi- cantly inversely correlated in the HCC clinical specimens, and CD90 + HCC samples or samples with decreased miR-589-5p expression showed more ... See full document
12
Investigation of mesenchymal stem cells and the development of experimental strategies for rescuing glaucomatous eyes using a stem cell based therapy
... BrdU-IR cells was observed at P4 ...to cells at other ...which cells were isolated [11, 41, 46] ...for cell isolation and culture, as well as general health conditions between individual ... See full document
187
A stem cell derived gene (Sddr) negatively regulates differentiation of embryonic stem cells
... Embryonic stem (ES) cells were established from inner cell mass (ICM) of mammalian blastocysts (Evans and Kaufman, 1981; Martin, ...ES cells require leukemia inhibitory factor (LIF) for ... See full document
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Schlicker, Andreas (2011): Einflussfaktoren auf die Proliferation und die neuronale Differenzierung humaner mesenchymaler Knochenmarkszellen. Dissertation, LMU München: Medizinische Fakultät
... die Expression von Nestin stark durch die Serum- konzentration der Kulturbedingung beeinflusst (Joannides et al, 2004; Wislet-Gendebin et al, 2005) und war daher für unsere Zwecke kein geeigneter ...Die ... See full document
134
A plant U box protein, PUB4, regulates asymmetric cell division and cell proliferation in the root meristem
... gain-of-function analyses have shown that exogenous applications of CLV3/CLE peptides or overexpression of CLV3/ CLE genes induce RM consumption and suggested a possibility that CLV3/CLE signaling pathway(s) ... See full document
10
Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics- mitochondrial priming
... survivor cells in drug-escape exhibited significantly reduced levels of succinate, fumarate and glutamate, despite significant increases in glutamine and glutamate, suggestive of reduced TCA cycle activity and ... See full document
15
Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches
... for cell adhesion and proliferation ...increase cell immunogenicity as a result of the internalization of animal proteins during in vitro expansion [14 – ...one cell therapy trial, anti- bodies ... See full document
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Phase I clinical study of RG7356, an anti-CD44 humanized antibody, in patients with acute myeloid leukemia
... Eighteen patients were not evaluable for dose- limiting toxicity (DLT) determination, owing to disease progression prior to day 21 (n = 9), early event of aseptic meningitis (n = 2), infusion-related reactions (IRRs) (n ... See full document
11
Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines
... identified based on bulk tumor analyses, have been utilized to predict prog- nosis and help determine appropriate targeted therapy ...recent development in targeted therapy, surgery and radiation ... See full document
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Arsenic trioxide induces differentiation of CD133+ hepatocellular carcinoma cells and prolongs posthepatectomy survival by targeting GLI1 expression in a mouse model
... Hep3B-LV-shGLI1 cells were obtained by infecting CD133 + Huh7-wt and CD133 + Hep3B-wt with a lentiviral vector encoding short hairpin RNA for GLI1 (sc-37911-V, Santa Cruz Biotech- nology, Santa Cruz, CA, USA) to ... See full document
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