[PDF] Top 20 Unusual DNA binding modes for metal anticancer complexes
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Unusual DNA binding modes for metal anticancer complexes
... organometallic complexes have dynamic stereogenic centres in aqueous ...chiral DNA allowing selection of the most favourable diasteromer for ...plasmid DNA, twice that of mononuclear 11 ...inhibited ... See full document
73
Metal complexes as potential anticancer agents
... time-dependent DNA binding experiments conducted with the complexes ...pUC9 DNA, compared to cisplatin at equivalent concentrations, with the unwinding of Form I to Form Io DNA ... See full document
163
SYNTHESIS, CHARACTERIZATION, AND DNA BINDING INTERACTION STUDIES OF A NEW MANNICH BASE AND IT’S METAL COMPLEXES
... interaction modes between these metal complexes and CT-DNA, the ethidiumbromide (EB) fluorescence displacement experiments were further ...of DNA is very low, and that of EB in Tris ... See full document
8
SYNTHESIS, CHARACTERIZATION OF MANNICH BASE TRANSITION METAL COMPLEXES: DNA BINDING AND ANTI BACTERIAL STUDIES
... the binding modes of complex with ...and DNA, viscosity measurements were carried ...a binding model in a solution in the absence of crystallographic structural data (Satyanarayana et ...the ... See full document
5
Application of analytical techniques for the study of metal based anticancer complexes
... The complexes under investigation are prodrugs that must be photoactivated to become ...the binding of DNA repair proteins to lesions formed on DNA by the metal ...platinum ... See full document
276
Metal complexes as DNA intercalators
... DNA binding. In particular, the cytotoxic activity of these complexes, conformational distortions, recognition by DNA-binding proteins and repair mechanisms are dependent on the ... See full document
46
Design, synthesis and spectral characterisation of novel acyclic ligand and their transition metal complexes as selective DNA binding agents
... of metal–drug complexes is of particular interest in the pharmacological ...research. Metal combinations with pharmaceutical agents are known to improve the activity of the drugs and decrease their ... See full document
11
Studies on dna cleavage, antimicrobial screening and anticancer activity of zr(iv) and th(iv) metal complexes of dfmpm and glycine
... the metal ion has a pronounced effect on the biological behavior by altering the binding ability of ...that metal has been suggested to facilitate oxidative tissue injury through a free radical ... See full document
7
Synthesis, molecular docking, DNA binding and biological evaluation of schiff base transition metal complexes
... and DNA interaction of metal complexes revealed that the synthesized compounds are highly ...the metal complexes exhibited good DNA binding property in the present study ... See full document
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Redox active and DNA binding coordination complexes of clotrimazole
... Platinum complexes are the most widely used metal-based anticancer drugs [1,2]; however, new generations of agents that also possess anticancer activity but which can widen the spectrum of ... See full document
31
Preparation and Physico-Chemical Investigation Studies for the of Mn(II),Co(II),Ni(II) and Cu(II) Metal Complexes with Ligand 2- Hydroxybenzaldine Urea Israa H. Ibraheem
... formation complexes, this change assigned to coordination imine with the metal ions [12] that there are no vibration of carbonyl group, this means that this group has not entered into coordination, through ... See full document
6
Binding of Natural Antioxidant, Curcumin with Metal- Salen Complexes
... [40]. Complexes 1-6 were prepared from the previously published reports ...the complexes were recorded in a JASCO FT/IR-430 spectrophotometer in KBr pellet ...of complexes (1 mM) along with the ... See full document
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Synthesis, Characterization and Antibacterial Activity and DNA cleavage Studies of tetra dentate Schiff bases and their Zn (II) Complexes
... analyzer. The conductance of the Zn (II) complexes was measured on a Digisun digital conductivity meter (model DI- 909). Infrared spectra in KBr/CsI pellets were recorded with a Perkin-Elmer 283 spectrophotometer. ... See full document
7
MACROCYCLIC METAL COMPLEXES: FROM STRUCTURE TO ACTIVITY
... of metal thiosemicarbazones often differ from those of either ligands or the metal ions which are considered to be related to metal ion coordination ...a metal complex rather than the parent ... See full document
9
DESIGN AND SYNTHESIS OF NEW PYRROLO[2,1-c][1,4] BENZODIAZEPINE HYBRIDS AS DNA INTERACTIVE ANTITUMOUR AGENTS
... covalent binding to the N2 of guanine in the minor groove of DNA through the imine or imine equivalent functionality at N10-C11 of ...B-form DNA leading to a snug fit at the binding ... See full document
17
catena Poly[[bis(N,N dimethylformamide)cobalt(II)] di μ 1,5 dicyanamido]
... of metal complexes. Polymeric dicyanamido complexes possess inter- esting magnetic properties and unusual coordination archi- tectures (Miller & Manson, ... See full document
8
Hints for Metal-Preference Protein Sequence Determinants: Different Metal Binding Features of the Five Tetrahymena thermophila Metallothioneins
... The metal binding preference of metallothioneins (MTs) groups them in two extreme subsets, the Zn/Cd- and the ...the metal-binding abilities of the five MTT proteins were characterized, to ... See full document
16
Reactivity and structural studies of metal complexes bound to DNA
... The DNA double helix is a remarkable molecular assembly for examining how a -stacked array mediates charge ...in DNA are "hot spots" for oxidative ...In DNA, the potentials also appear to be ... See full document
29
Binding studies of some novel macroacyclic transition metal complexes towards CT DNA via multispectroscopic techniques
... relative DNA binding properties of the complexes to calf thymus (CT- DNA in 50 mM Tris HCl / 1 mM NaCl buffer, pH ...the complexes. The relative binding tendency of the ... See full document
18
A mutation that causes lability of the androgen receptor under conditions that normally promote transformation to the DNA binding state
... testosterone-mediated events. These findings suggest that dihydrotestosterone may amplify the androgenic signal at its targets not only by its higher affinity for the receptor but also by its more efficient conversion to ... See full document
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