[PDF] Top 20 Virus Entry via the Alternative Coreceptors CCR3 and FPRL1 Differs by Human Immunodeficiency Virus Type 1 Subtype
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Virus Entry via the Alternative Coreceptors CCR3 and FPRL1 Differs by Human Immunodeficiency Virus Type 1 Subtype
... efficient entry via both CCR5 and CCR3 (1–3, 5, 17, 61), and some (77, 78) suggest possible target cell adaptation by this prevalent subset of HIV-1 ...typing CCR3 use could have ... See full document
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The CCR5 and CXCR4 Coreceptors Are Both Used by Human Immunodeficiency Virus Type 1 Primary Isolates from Subtype C
... that subtype C viruses were as sensi- tive as subtype B viruses to the CCR5 inhibitors, PRO 140, RANTES, and TAK-779 ...coreceptor-specific entry inhibitors in South Africa; the antiviral responses ... See full document
8
Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry.
... CD4 1 blood cell counts were less than 190 cells mm 23 except for the patients from whom isolates 2076 and 3028 were derived; these individuals had CD4 counts of 400 and 328, ...of subtype B except for ... See full document
6
Genetically Divergent Strains of Human Immunodeficiency Virus Type 2 Use Multiple Coreceptors for Viral Entry
... as coreceptors for entry by human immunodeficiency virus type 1 ...multiple coreceptors were syncytium ...CCR2b, CCR3, CCR4, CCR5, CXCR4, BONZO, and BOB) ... See full document
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Construction and Analysis of an Infectious Human Immunodeficiency Virus Type 1 Subtype C Molecular Clone
... one virus reached peak titers sooner than the ...HIV-1 subtype C viruses may be unique in that variants that use coreceptors other than CCR5 may be very ...as coreceptors for cell ... See full document
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Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates
... other coreceptors, since it does not intro- duce the selection bias associated with viral isolation ...that CCR3, CXCR4, and other coreceptors are expressed at higher levels in the CNS of individuals ... See full document
9
Expression and Use of Human Immunodeficiency Virus Type 1 Coreceptors by Human Alveolar Macrophages
... Human immunodeficiency virus type 1 (HIV-1) requires, in addition to CD4, coreceptors of the CC or CXC chemokine families for productive infection of T cells and cells of ... See full document
10
Patterns of CCR5, CXCR4, and CCR3 Usage by Envelope Glycoproteins from Human Immunodeficiency Virus Type 1 Primary Isolates
... of coreceptors and/or CD4 on different target cell types may critically influence permissiveness (31, 44, 48), and thresh- old effects might have different consequences for cell fusion versus virus ... See full document
7
Cloning and Analysis of Sooty Mangabey Alternative Coreceptors That Support Simian Immunodeficiency Virus SIVsmm Entry Independently of CCR5
... (APJ, CCR3, CCR8, CXCR6, GPR1, and GPR15) or SM cDNA (CCR2b, CCR4, and CXCR4) from animals housed at the Yerkes National Primate Research Center ...to human and rhesus macaque mRNA published in ...cDNA, ... See full document
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Infectious Simian/Human Immunodeficiency Virus with Human Immunodeficiency Virus Type 1 Subtype C from an African Isolate: Rhesus Macaque Model
... cell entry (28, ...CCR2(b), CCR3, or CXCR4 as a coreceptor for cell entry (36, ...HIV-1 subtype C-based SHIV chimera (10), is shown in ...HIV-1 subtype B for it to be ... See full document
9
Role of the β-Chemokine Receptors CCR3 and CCR5 in Human Immunodeficiency Virus Type 1 Infection of Monocytes and Microglia
... Human immunodeficiency virus type 1 (HIV-1) infection in mononuclear phagocyte lineage cells (monocytes, macrophages, and microglia) is a critical component in the pathogenesis ... See full document
11
Will Multiple Coreceptors Need To Be Targeted by Inhibitors of Human Immunodeficiency Virus Type 1 Entry?
... These coreceptors are, therefore, of clear and obvious interest as targets for antiviral drug ...viral entry and/or fusion assays in vitro. These include CCR2b (18), CCR3 (1, 4, 11, 25, 39), ... See full document
6
Early Evolution of the Human Immunodeficiency Virus Type 1 Subtype C Epidemic in Rural Malawi
... early subtype C sequences in Karonga fell into two groups, which corresponded to clusters 1 and 2 and which were separated with 99 BP when analyzed on their ...cluster 1, were less than the distances ... See full document
10
Neutralizing Antibody Responses in Acute Human Immunodeficiency Virus Type 1 Subtype C Infection
... The virus sensitivity profile was more akin to that of the primary viruses in the subtype C panel that had been cultured than to those of viruses cloned directly from plasma ...the virus obtained ... See full document
10
Human Immunodeficiency Virus Type 1 Subtype Distribution in the Worldwide Epidemic: Pathogenetic and Therapeutic Implications
... non-B subtype sequences from 3,686 individuals showed (i) that most of the protease and RT positions associated with drug resistance in subtype B viruses are selected by ART in one or more non-B subtypes as ... See full document
11
Human Immunodeficiency Virus Type 1 and Influenza Virus Exit via Different Membrane Microdomains
... of virus-like particles from such cells was inhibited by K41 (data not ...enza virus envelope glycoprotein HA, whether expressed alone (data not shown) or expressed together with the other viral components ... See full document
11
Novel Envelope Determinants for CCR3 Use by Human Immunodeficiency Virus
... affecting CCR3 usage. Interestingly, Env 8.9.J could use CCR3 efficiently despite having D356, suggesting that other regions may compensate for this CCR3 determinant ... See full document
6
Adaptation of Subtype A Human Immunodeficiency Virus Type 1 Envelope to Pig-Tailed Macaque Cells
... structure via other steric ...on human PBMCs, Ptm PBMCs, and immortalized Ptm ...of human and Ptm ...and human sequences differ, the corresponding residue encoded by Ptms is ... See full document
12
Cytosolic Gag p24 as an Index of Productive Entry of Human Immunodeficiency Virus Type 1
... of virus particles attached at the cell surface, as observed by flow cytometry analysis (data not shown), and led to a contamination of both the vesicular and cytosolic fractions with extracellular ...control ... See full document
5
Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line.
... To further investigate the hypothesis that U373-CD4 cells lack a cofactor necessary for CD4-mediated viral entry, we established hybrid cell clones after PEGmediated fusion of U373-CD4 c[r] ... See full document
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