anaphase-promoting complex/cyclosome
Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5
... Human cytomegalovirus (HCMV) deregulates the cell cycle by several means, including inactivation of the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase. Viral proteins UL97 ...
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Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
... The anaphase promoting complex or cyclosome (APC/C) is a multi-subunit cullin-RING E3 ubiquitin ligase that functions to regulate progression through the mitotic phase of the cell cycle and to ...
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Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase promoting complex/cyclosome
... the anaphase-promoting complex/ cyclosome (APC/C), in regulating the basal localisation of ...protein complex with at least 11 core subunits that functions as an E3 ubiquitin ligase ...
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The Anaphase-Promoting Complex/Cyclosome Is Required for Anaphase Progression in Multinucleated Ashbya gossypii Cells
... The anaphase-promoting complex/cyclosome (APC/C) is responsible for the protein destruction required for the initiation of anaphase and the exit from mitosis, including the degradation ...
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Orthologues of the Anaphase-Promoting Complex/Cyclosome Coactivators Cdc20p and Cdh1p Are Important for Mitotic Progression and Morphogenesis in Candida albicans
... Cdc20p is important for the metaphase-to-anaphase tran- sition and mitotic exit. Our characterization of CDC20 and CDH1 provides the first picture of a potential APC/C func- tion in C. albicans. Since ...
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In Vivo Characterization of the Nonessential Budding Yeast Anaphase-Promoting Complex/Cyclosome Components Swm1p, Mnd2p and Apc9p
... We have examined the in vivo requirement of two recently identified nonessential components of the budding yeast anaphase-promoting complex, Swm1p and Mnd2p, as well as that of the previously ...
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Apoptin Nucleocytoplasmic Shuttling Is Required for Cell Type-Specific Localization, Apoptosis, and Recruitment of the Anaphase-Promoting Complex/Cyclosome to PML Bodies
... Several studies have shown that cells respond to various types of stimuli by increasing both the size and the number of PML nuclear bodies (11, 23, 43). In addition to established roles in tumor suppression and ...
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Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome
... Relative time difference between degradation of Cyc- lin A and Securin is important to contribute to ordered progression of mitosis. While Cyclin A promotes the detachment of kinetochores from the microtubules, its ...
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The function of APC/CCdh1 in cell cycle and beyond
... (anaphase promoting complex/ cyclosome), control the timely transitions of cell cycle phases by promoting the degradation of many key cell cycle ...SCF complex mainly functions ...
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HTLV 1 Tax mutants that do not induce G1arrest are disabled in activating the anaphase promoting complex
... the anaphase inhibitor: securin/Pds1p (precocious dissociation of sister chromatids) were found to be significantly reduced ...the anaphase promoting complex/cyclosome (referred to as ...
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Changes in the Localization of the Saccharomyces cerevisiae Anaphase-Promoting Complex Upon Microtubule Depolymerization and Spindle Checkpoint Activation
... The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase in the ubiquitin-mediated proteolysis pathway ...late anaphase, the Cdc23-GFP was also visualized along the ...
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The ubiquitin system: orchestrating cellular signals in non-small-cell lung cancer
... APC/C: Anaphase-promoting complex/cyclosome; CHIP: Carboxy terminus of Hsc70 interacting protein; DAXX: Death domain-associated protein; DUBs: Deubiquitinating enzymes; EGF: Epidermal growth ...
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Nuclear pore protein NUP88 activates anaphase promoting complex to promote aneuploidy
... In HeLa cells, altered expression of NUP88 has been associ- ated with multinucleation and centrosome amplification, linking NUP88 and mitosis through an unknown mechanism (4). These observations are in alignment with the ...
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Control the Host Cell Cycle: Viral Regulation of the Anaphase-Promoting Complex
... would be targeted by viruses. An accumulating body of literature in recent years has identified multiple viral proteins that can mod- ulate the function of the APC. They do so via a diverse array of mechanisms, ...
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Multiple Subunits of the Caenorhabditis elegans Anaphase-Promoting Complex Are Required for Chromosome Segregation During Meiosis I
... Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or ...
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Dim1p Is Required for Efficient Splicing and Export of mRNA Encoding Lid1p, a Component of the Fission Yeast Anaphase-Promoting Complex
... the anaphase- promoting complex or cyclosome (APC/C) component Lid1p and thus for maintaining the steady-state level and activity of the ...tri-snRNP complex. Moreover, we find that ...
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Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
... APC/C: Anaphase-promoting complex or cyclosome; CASC2: Cancer susceptibility candidate 2; CRL: Cullin-RING E3 ligase; CRPC: Castration- resistant prostate cancer; CSCs: Cancer stem cells; EMT: ...
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The Anaphase Promoting Complex Contributes to the Degradation of the S. cerevisiae Telomerase Recruitment Subunit Est1p
... cells from mitotic arrest. CDC15 encodes a protein kinase required for mitotic exit and incubation of cdc15-2 cells at the restrictive temperature of 37uC results in cell cycle arrest in late anaphase/ telophase ...
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Contribution of CAF-I to Anaphase-Promoting-Complex-Mediated Mitotic Chromatin Assembly in Saccharomyces cerevisiae
... The chromatin assembly machinery potentially targeted by the APC would be expected to be mitosis specific, since the main function of the APC is to promote passage through mi- tosis. However, of all the CAFs identified, ...
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The Saccharomyces cerevisiae Anaphase-Promoting Complex Interacts with Multiple Histone-Modifying Enzymes To Regulate Cell Cycle Progression
... necessary for mitotic exit and passage through G 1 /S. Complete transcriptional initiation and elongation, however, appear to require both Gcn5 and the HAT component of the Elongator complex, Elp3 (36, 67, 68). ...
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