Balancing selection
Detecting Ancient Balancing Selection: Methods And Application To Human
... Balancing selection can maintain genetic variation in a population over long evolutionary time ...of selection not only elucidates selective pressures and adaptations but can also help interpret ...
121
Balancing Selection in Species with Separate Sexes: Insights from Fisher’s Geometric Model
... mutation, selection, migra- tion, recombination, and genetic drift account for the main- tenance of genetic variation in natural ...them. Balancing selection—selection that maintains genetic ...
25
The Effects of Multilocus Balancing Selection on Neutral Variability
... multilocus balancing selection on neutral nucleotide variability at linked sites by simulating a model where diallelic polymorphisms are maintained at an arbitrary number of selected loci by means of ...
16
Recombination, Balancing Selection and Phylogenies in MHC and Self-Incompatibility Genes
... multiallelic balancing selection with recombination, the genealogical process as a function of recombinational distance from a site under selection is ...under selection, converging with ...
12
Long term balancing selection contributes to adaptation in Arabidopsis and its relatives
... under balancing selection are a good system to understand the mechanism of ...weak selection strength [53, 54]. How- ever, balancing selection can act through a variety of mechanisms ...
15
Balancing Selection at Closely Linked, Overdominant Loci in a Finite Population
... of balancing selection, mutation, recombination, and genetic drift at two closely linked loci and compares the theoretical predic- tions with published surveys of the MHC class II loci, DQA1 and DQB1, in ...
12
Population genetic analysis of the Plasmodium falciparum 6 cys protein Pf38 in Papua New Guinea reveals domain specific balancing selection
... and selection of Pf38 in two ...significant balancing selection, sug- gesting that the gene is a target of natural ...immune selection, supporting the hypothesis that it may be the ...
9
Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird
... Colour polymorphisms play a key role in sexual selection and speciation, yet the mechanisms that generate and maintain them are not fully understood. Here, we use genomic and tran- scriptomic tools to identify the ...
12
EVIDENCE FOR BALANCING SELECTION AT HLA
... As a result of this consideration of possible causes for the observed reduced homozygosity it appears that some form of symmetrical balancing selection, and not stratificat[r] ...
8
Two modes of balancing selection in Drosophila melanogaster: overcompensation and overdominance.
... T h e fitness component investi- gated is egg-to-adult survival in such a way that it cannot be attributed to the genotype of the mother (or of the father) as suc[r] ...
11
Polymorphism and balancing selection at major histocompatibility complex loci.
... Theory suggests that the number of alleles that differ at the sites targeted by selection (presumably the nonsynonymous sites in the PBR) should be equal to the [r] ...
14
DNA Polymorphism, Haplotype Structure and Balancing Selection in the Leavenworthia PgiC Locus
... staff for plant care. D. Charlesworth was supported by the Natural Hudson, R. R., and N. L. Kaplan, 1988 The coalescent process in Environment Research Council of Great Britain, and D. A. Filatov models with ...
12
Molecular evolution of the sheep prion protein gene
... by balancing selection, a profoundly different process from that seen in other ...positive selection in response to ...this balancing selection, and may have a negative impact on the ...
8
Evolutionary explanations in medical and health profession courses: are you answering your students' "why" questions?
... natural selection that operates to keep two or more beneficial alleles at relatively high frequencies ...disease, balancing selection and heterozy- gote advantage, are still not found in many medical ...
7
Contrasting patterns of nucleotide polymorphism suggest different selective regimes within different parts of the PgiC1 gene in Festuca ovina L.
... An earlier study [34] identified two F. ovina PgiC1 codon sites (sites 173 and 200) as candidate targets of balancing selection (i.e. positive intraspecific diversifying selection) with a ...
10
Persistence of Mhc Heterozygosity in Homozygous Clonal Killifish, Rivulus marmoratus: Implications for the Origin of Hermaphroditism
... mable Thermal Controller (MJR, Biozym, Hess. Oldendorf, highly polymorphic (Klein and Figueroa 1986) with Germany) or in the GeneAmp PCR System 9700 (AB Applied a large number of highly divergent alleles (allelic lin- ...
14
The Genealogy of Sequences Containing Multiple Sites Subject to Strong Selection in a Subdivided Population
... balancing selection usually causes a “peak” due to diver- Given such an event, the breakpoint can be anywhere in gence between the two allelic ...trans-heterozy- balancing selection or (many ...
14
Structured Coalescent Processes on Different Time Scales
... Furthermore, simulation of models that include balancing selection (NORDBORG et al. CHARLESWORTH, unpublished data) indicate that the statement that background selection [r] ...
14
A MOLECULAR APPROACH TO THE STUDY OF GENIC HETEROZYGOSITY IN NATURAL POPULATIONS IV. PATTERNS OF GENIC VARIATION IN CENTRAL, MARGINAL AND ISOLATED POPULATIONS OF DROSOPHILA PSEUDOOBSCURA
... Variation at a locus within a population will be maintained by some form of balancing selection like heterosis, by selection in favor of one allele, the “wild type” opposed [r] ...
18
DNA Sequence Variation at the Period Locus Reveals the History of Species and Speciation Events in the Drosophila virilis Group
... novamexicana is a single spe- cies with balancing selection maintaining two function- ally distinct per alleles, then a history of per locus recombination is also expecte[r] ...
11