BH3-only
VEGF B inhibits apoptosis via VEGFR 1–mediated suppression of the expression of BH3 only protein genes in mice and rats
... proapoptotic BH3-only proteins and other apoptosis- and cell death–related proteins, including p53 and members of the caspase family, via activation of ...
12
The Fowlpox Virus BCL-2 Homologue, FPV039, Interacts with Activated Bax and a Discrete Subset of BH3-Only Proteins To Inhibit Apoptosis
... by BH3-only proteins. The BH3-only proteins are proapoptotic members of the Bcl-2 family that induce apoptosis by facilitating the activation of both Bak and Bax ...
14
Evidence for Involvement of BH3-Only Proapoptotic Members in Adenovirus-Induced Apoptosis
... of BH3-only proteins: one at the level of BAK activation (10) and the second at the level of transcrip- tional activation of caspases ...the BH3-only proteins are apical ...dissect ...
10
Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM
... A search for additional AP-1 induced apoptotic targets revealed the induction of the proapoptotic BIM gene upon TMZ/ACNU exposure. BIM was originally identified as a Bcl-2-interacting protein [50]. Multiple isoforms were ...
14
Insulin like growth factor 1 attenuates antiestrogen and antiprogestin induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3 only pro apoptotic protein Bim
... Our studies are based on the hypothesis that targeting PR along with ER should more effectively reduce breast cancer cell growth than does treatment with an anties- trogen, because progesterone, like estrogen, is ...
20
Apoptosis inducers in chronic lymphocytic leukemia
... The BH3 mimetic concept prompts the development of small molecules capable of mimicking the BH3- only proteins which are natural, direct antagonists of the prosurvival Bcl-2 ...generated BH3 ...
17
Cusack_unc_0153D_14350.pdf
... Bax activation can also require BH3-only sensitizers (Bad, Bmf, DP5, Bik, Noxa) that bind and inhibit anti-apoptotic proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1). These anti-apoptotic protei[r] ...
253
A C-terminus Mitochondrial-localization Region and BH3 Domain of Puma are Required for Apoptotic Function
... prevalence of membrane-localization sequences among the Bcl-2 family members is merely coincidental. It is possible that these proteins localize to membranes in order to increase the chances of coming near enough to each ...
121
Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L
... as BH3-only proteins that perform dual functions by directly activating Bak and Bax or by sequestering and neutralizing antiapoptotic family ...ptotic BH3-only protein Bim that ultimately ...
11
Sequence and partial functional analysis of canine Bcl 2 family proteins
... still debated, it did not visibly interfere with the experiments in this study. Expression of canine Bcl-2 family members in yeast has not been described before. Here, we successfully performed a functional analysis of ...
48
Bourhis, Hélène (2019): Chemoimmuntherapie des Pankreaskarzinoms: Kombination von Gemcitabin mit Liganden von RIG-I-like Helikasen. Dissertation, LMU München: Medizinische Fakultät
... Um auch in vivo den Effekt einer Gemcitabin-Behandlung auf die Expression der BH3- only Proteine Puma und Noxa zu untersuchen, wurde das Chemotherapeutikum zunächst im or[r] ...
89
The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function.
... the BH3 domain in isolation ...the BH3 peptides with the anti-apoptotic and pro-apoptotic-effector Bcl-2 proteins have been studied thoroughly in vitro, however, the BH3-only proteins are not ...
9
Activation of Tumor Suppressor Protein p53 Is Required for Theiler's Murine Encephalomyelitis Virus-Induced Apoptosis in M1-D Macrophages
... binds only to Mcl-1 and A1 (2). After the binding of proapoptotic BH3-only proteins to pro- survival Bcl-2 family members, degradation of the prosurvival proteins releases Bak/Bax, which form ...
8
Predicting effective pro-apoptotic antileukaemic drug combinations using co-operative dynamic BH3 profiling
... The BH3-only apoptosis agonists BAD and NOXA target BCL-2 and MCL-1 respectively and co-operate to induce ...dynamic BH3 profiling, whereby cells were primed with drugs to discover whether this would ...
19
Boolean network-based model of the Bcl-2 family mediated MOMP regulation
... into only three types: i) Binding and mutual inhibition between antiapoptotic and BH3-only pro- ...by BH3-only ...the BH3-only sensitizer Noxa can bind to and inhibit ...
14
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT 737
... call BH3 profiling. BH3 profiling accurately predicts sensitivity to BCL2 antagonist ABT-737 in primary chronic lymphocytic leukemia (CLL) ...cells. BH3 profiling also accu- rately distinguishes ...
11
5670.pdf
... The direct activation model proposes that specific BH3-only proteins can directly interact with and activate the effector proteins BAX and BAK. The sensitization model says th[r] ...
190
BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells
... that BH3 peptides from Bad, Noxa, and Hrk can be used as functional probes for Bcl-2, Mcl-1, and Bcl-xL, respectively ...human BH3-only protein that does not bind antiapoptotic Bcl-2 proteins nor ...
8
Not-only-a-title
... Luigi Grassi, MD Director Unit of Psycho-Oncology Azienda Ospedaliera Universitaria di Ferrara Arcispedale S. Anna, Ferrara, Italy I have read all of these materials and I think the debate is interesting. Naming ...
10
Focus on “Only” and “Not”
... FOCUS ON 'ONLY' AND 'NOT' F()C, I )N "()NI X" ANI) "N()T" A l l a n I b m l s a y I ) e l ) l o1! (2onll)Ul;(+r Sci('nc( , [ ) u i v c r s i t ; v (<,ollcgc I ) u l ) t i n , al lan(~monkey, u c d i e[.] ...
5