Cell Clones
Population genetics of cancer cell clones: possible implications of cancer stem cells
... genetic clones within a given cancer mutate, compete and evolve resulting in the final outcome of a malignant ...cancer cell clones can be thought of essentially as sym- patric asexual species [3,5], ...
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T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones
... T-cell clones that were only capable of recognising targets displaying high densities of cognate ...the clones generated by this method were often capable of recognising lower levels of peptide, as ...
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Herpesvirus Saimiri Transforms Human T-Cell Clones to Stable Growth without Inducing Resistance to Apoptosis
... specific cell death and proliferation were measured, and almost iden- tical dose-response curves were ...parental clones 1 day after activation ...of cell death induction (Fig. 6). TNF-a did not ...
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Characteristics and functions of Sendai virus-specific T-cell clones.
... The intravenous inoculation of T-cell clones, such as 2H3.B8, 2H3.E8, or 2H3.A5 106 cells per mouse, into mice which had received intranasally a lethal dose of SV 24 h earlier augmented [r] ...
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Dengue virus-specific, human CD4+ CD8- cytotoxic T-cell clones: multiple patterns of virus cross-reactivity recognized by NS3-specific T-cell clones.
... DISCUSSION In this article we have reported that i Dengue virusspecific, human CD4+ CD8- T-cell clones are heterogeneous with at least six patterns of virus and serotype specificities; i[r] ...
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Suppressor T cell clones from patients with acute Epstein Barr virus induced infectious mononucleosis
... T cell clones derived from the peripheral blood of two patients with acute EBV-induced infectious mononucleosis (IM) yielded 11 highly suppressive clones that had no cytotoxic activity for the ...
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Identification of expanded T-cell clones by spectratyping in nonfunctioning kidney transplants
... In spite of the small sample size and differences in the patient population, these findings show a certain consistency with a recent report by Morris et al, who described a drop in donor-reactive T-cell ...
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Herpesvirus Entry Mediator HVEM Mediates Cell-Cell Spread in BHK(TK−) Cell Clones
... washed cell pellet was resuspended in PBS containing 1% bovine serum albumin and a 1:600 dilution of anti-HVEM antiserum R133 (gift of Gary Cohen and Roselyn Eisen- berg) (31), and antibody was allowed to bind for ...
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High-Throughput, Sensitive Quantification of Repopulating Hematopoietic Stem Cell Clones
... stem cell engraftment, regulatory decisions of individual stem cells, and genotoxicity of retroviral vectors (17, 22, 23, 25, 29, 31, ...HPSC clones repopulating in humans or nonhuman primates is much ...
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The Polyomavirus BK Large T-Antigen-Derived Peptide Elicits an HLA-DR Promiscuous and Polyfunctional CD4+ T-Cell Response
... T-cell clones revealed that all clones were CD4 ⫹ CD28 ⫺ and had the effector mem- ory phenotype (CD45RO ⫹ CD45RA ⫺ CCR7 ⫺ CD62L ⫺ ...T-cell clones studied corresponds to that of highly ...
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A novel HIV 1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM NKR
... in clones #4 and #7 from 16 days postinfec- ...derived cell clone #4, #5, and ...non-permissive cell clones was due to an over- expression of any A3 cytidine deaminases, we measured protein ...
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Epstein-Barr Virus Transforming Protein LMP1 Plays a Critical Role in Virus Production
... The Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1), which is critical for EBV-induced B-cell transformation, is also abundantly expressed during the lytic cycle of viral replication. However, the ...
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Developmental analysis and squamous morphogenesis of the peripodial epithelium in Drosophila imaginal discs
... in cell number between the PE and DP In different imaginal discs, the number of cells that compose the PE and DP differs dramatically by the end of the third larval instar; our analyses, however, indicate that ...
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Development of Murine Leukemia Virus-Based Self-Activating Vectors That Efficiently Delete the Selectable Drug Resistance Gene during Reverse Transcription
... Most retroviral vectors used for gene therapy are based on murine leukemia virus (MLV) and express a gene of interest as well as a drug resistance gene. A drug resistance gene is typi- cally necessary for selection of ...
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Disease associated human histocompatibility leukocyte antigen determinants in patients with seropositive rheumatoid arthritis Functional role in antigen specific and allogeneic T cell recognition
... T cell recognition we generated T cell clones from RA patients specific for mycobacterial antigens, Epstein-Barr virus antigens, and tetanus ...T cell clones were restricted to either ...
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Inhibition of simian virus 40 T-antigen expression by cellular differentiation.
... Although none of the other clones differentiated as well as CSV3-1, repression of T-antigen expression was observed in all these cell clones as they underwent adipocyte differentiation, [r] ...
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Determination of the rate of base-pair substitution and insertion mutations in retrovirus replication.
... performed this amplification on DNAs from seven neor D17 cell clones originally infected with JD216Neo AmHy virus from .2G helper cell clones and on six DNAs from cells originally infect[r] ...
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Density dependent inhibition of both growth and T-antigen expression in revertants isolated from simian virus 40-transformed mouse SVT2 cells.
... Revertant clones with increased adherence were selected from cultures of SVT2, a simian virus 40-transformed BALB/c mouse cell line, and screened to find arrestable revertant clones whic[r] ...
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Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells.
... Furthermore, by differential sorting of neomycin-resistant cell populations, clones were isolated in which lacZ expression was induced and repressed in growth-arrested and log phase cell[r] ...
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Identification of T-cell epitopes on E2 protein of rubella virus, as recognized by human T-cell lines and clones.
... E2-4 peptide induced strong cytotoxic reactions of T-cell clone A9 to the MANN and EBV-BL AT cell targets but no responses to human cell lines MAJA, MST, WT-20, PRIESS, or Lg-38 with dif[r] ...
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