Complement Factor
The molecular basis of hereditary complement factor I deficiency
... hereditary complement factor I defi- ciency is described in two ...two factor I–deficient siblings, one of whom was asymp- tomatic and the other suffered from recurrent pyogenic in- ...Their ...
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Complement factor I deficiency: a not so rare immune defect. Characterization of new mutations and the first large gene deletion
... (C4BP), Complement Factor H (CFH), Comple- ment Receptor 1 (CR1/CD35) and Membrane Cofactor Protein (MCP/CD46) ...of Complement Factor B (CFB) and CFH are also related with CFI deficiency ...
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Associations of complement factor B and complement component 2 genotypes with subtypes of polypoidal choroidal vasculopathy
... disease. Complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2) and high-temperature requirement factor A1 (HTRA1) have been shown to be associated with AMD in both Japanese and ...
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Complete and partial deficiencies of complement factor D in a Dutch family
... serum complement factor D hemolytic ...purified factor D to a final concentration of 1 microgram/ml resulted in full restoration of the activity of the alternative ...of factor D antigen ...
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A family with complement factor D deficiency
... A complement factor D deficiency was found in a young woman who had experienced a serious Neis- seria meningitidis infection, in a deceased family member with a history of meningitis, and in three rel- ...
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Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus, and decreases complement mediated phagocytosis
... serum factor I. Wells of an ELISA plate were coated with a goat anti-factor I antibody at a 1:1000 dilution in carbonate buffer for 4 hours, washed with PBS ...serum factor I onto the ...
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Complement factor H contributes to mortality in humans and mice with bacterial meningitis
... of complement activation leads to a de- creased initial inflammatory response and a decreased bacterial ...system. Complement components are expressed at low levels in the central nervous ...infection, ...
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Proteomic alterations of HDL in youth with type 1 diabetes and their associations with glycemic control: a case–control study
... A1BG: alpha-1B-glycoprotein; ALBU: albumin; APOA4: apolipoprotein A-IV; CEC: cholesterol efflux capacity; C03: complement C3; CFAH: complement factor H; CVD: cardiovasular disease; FHR[r] ...
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A pharmacogenetics study to predict outcome in patients receiving anti-VEGF therapy in age related macular degeneration
... Purpose: To ascertain whether single nucleotide polymorphisms (SNPs) in the Vascular Endothelial Growth factor (VEGFA), Complement Factor H (CFH), and LOC387715 genes could p[r] ...
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Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients
... = 1), a missense variant coding for an asparagine to tyrosine substitution at amino acid 1,050 of the complement factor H (CFH) gene. The missense variant was not present in our association results, as it ...
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A case report of recurrent C3 glomerulonephritis 18 months after renal transplantation
... nephritic factor, factor H antibody, nor the complement factor H (CFH), complement factor I (CHI), and complement factor H-related 1-5 (CFHR1-5) genes were ...
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Genetic ablation of complement C3 attenuates muscle pathology in dysferlin deficient mice
... the complement factors, including C1qa, C1qb, C1qc, C4, Cfd, and DAF, to be differentially ...initiating complement factor C1qa for the clas- sical complement pathway was elevated in skeletal ...
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Haemolytic uraemic syndrome associated with non shiga toxin-producing Escherichia coli bacteraemia: a case report
... of complement al- ternative pathway genes, and this revealed a heterozy- gous variant in the gene encoding complement factor H ...A). Factor H (FH) is the key regulator of the alternative ...
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Inhibition of the activation of Hageman factor (factor XII) by complement subcomponent C1q
... Hageman factor (HF, Factor XII) is activated by glass, collagen, and ellagic acid, and initiates blood coagulation via the intrinsic pathway. C1q inhibits collagen-induced platelet aggregation and adherence ...
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Structural studies of factor B of the alternative pathway of the complement system
... the complement system detect “targets” and bind to them, usually by mechanisms that involve the recognition of charge distribution patterns or of carbohydrate on the surface of the ...of complement proteins ...
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Complement receptor 2–mediated targeting of complement inhibitors to sites of complement activation
... The CR2 fusion proteins inhibited the binding of U937 cells to C3-opsonized erythrocytes. CR2 and CR3 both bind iC3b, and our data indicate that CR2 fusion proteins act as CR3 antagonists, since U937 binding to ...
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What does complement do in Alzheimer’s disease? Old molecules with new insights
... as complement inhibitors CD55, CD59 on the cell surface (a phenomenon referred to as homologous ...two complement inhibitors, CD55 and CD59, are glycosylphosphatidyl- inositol (GPI)-anchored cell membrane ...
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Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b
... disease. Complement-mediated opsonization is a critical host defense against many pathogenic bacteria, and C3, the central complement component, plays an important role in host defense against ...by ...
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Mechanisms of activation of the classical pathway of complement by Hageman factor fragment
... delineated. When serum or platelet-poor plasma was incubated with various concentrations of HFf, the total complement hemolytic activity was reduced in a dose-dependent manner. This activation appears to be due to ...
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Expression of complement proteins C2 and factor B in transfected L cells
... similar complement proteins encoded by genes that are closely linked within the class III region of the major histocompatibility complex ...murine factor B and C2 were introduced into mouse L cells by ...
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