dissolution rate enhancement
Formulation and evaluation of solid dispersions of Flurbiprofen for dissolution rate enhancement
... that dissolution of the Flurbiprofen could be improved by solid dispersions and PEG 6000 based Solid dispersions are more effective in the enhancing the ...The dissolution of a poorly/sparingly soluble drug ...
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SURFACE SOLID DISPERSION OF DOMPERIDONE FOR DISSOLUTION RATE ENHANCEMENT
... drugs. Among various approaches, solid dispersion has shown promising results in improving the solubility, wettability, dissolution rate and subsequently its bioavailability. Only a few commercial solid ...
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DEVELOPMENT OF FAST RELEASE FORMULATION FOR DISSOLUTION RATE ENHANCEMENT
... A drug substance is initially dispersed in the nonvolatile solvent systems (Polysorbate 80, PEG-200) termed as liquid vehicles with different drug: vehicle ratios. Then a mixture of carrier or different polymers and ...
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Formulation development and dissolution rate enhancement of efavirenz by solid dispersion systems
... the dissolution profile of EFV from the solid dispersions prepared in PEG 8000 in 1:10 ...the dissolution data up to 10 and 30 min; Q 10 and Q 30 ...corresponding dissolution efficiencies are shown ...
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FORMULATION AND EVALUATION OF ACECLOFENAC SOLID DISPERSIONS FOR DISSOLUTION RATE ENHANCEMENT
... and/or dissolution rate, therefore major problems associated with these drugs was its very low solubility in biological fluids, which results into poor bioavailability after oral ...improve ...
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COMPARISON OF LIQUISOLID AND INCLUSION COMPLEXATION TECHNIQUE FOR DISSOLUTION RATE ENHANCEMENT OF VALSARTAN
... Dissolution studies of liquisolid tablets were carried out in USP Apparatus II (Paddle type) (Electro Lab). Tablets were placed in dissolution vessel containing 900 ml simulated gastric fluid maintained at ...
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Formulation and evaluation of solid dispersions of fenofibrate for dissolution rate enhancement
... the dissolution of Fenofibrate solid dispersions as better than that of prepared Fenofibrate solid dispersions using these polymers as carriers individually and this Was increased with the increase of polymer ...
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DISSOLUTION RATE ENHANCEMENT OF FEBUXOSTAT BY LIQUISOLID TECHNIQUE
... the dissolution rate of poorly soluble drug Febuxostat by delivering the drug as a liquisolid ...vitro dissolution study. The solubility and dissolution rate were found significantly ...
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APPLICATION OF SOLID DISPERSION TECHNIQUE IN SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF NATEGLINIDE
... Nateglinide is a quick acting anti-diabetic medication whose potent activity lasts for a short duration. The present investigation was aimed at developing a safe and effective controlled release dosage form of ...
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SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF EZETIMIBE BY SOLID DISPERSION AND PELLETIZATION TECHNIQUES
... as enhancement of drug dissolution; ease of coating with desirable release characteristics including sustained, controlled, delayed, site-specific, or pulsatile delivery of drug from coated pellets; uniform ...
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ENHANCEMENT OF DOMPERIDONE DISSOLUTION RATE VIA FORMULATION OF ADSORBATES AND CO ADSORBATES
... the dissolution rate of water- insoluble, weakly basic antiemetic drug; Domperidone (DMP), through the formulation of adsorbates and ...the dissolution rate ...in-vitro dissolution ...
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Drug resinates an attractive approach of solubility enhancement of atorvastatin calcium
... faster dissolution rate of complexed ATV compared to its unprocessed ...solubility enhancement of even very weakly acidic as well as basic, but ionisable poorly soluble drug molecules with low ...
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ENHANCEMENT OF DISSOLUTION RATE OF OXCARBAZEPINE BY USING VARIOUS SOLID DISPERSION TECHNIQUES
... station dissolution test apparatus equipped with paddles employing pH ...of dissolution medium throughout the ...The dissolution profiles were depicted in in Tables: 4, 5, 6 to 7 and Figure: 2 ...
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Studies on enhancement of dissolution rate of etoposide
... increased dissolution rate. The increase in dissolution might be due to increase in the wettability of hydrophobic drug like etoposide and also lowering effect of surface tension, hence increasing ...
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ENHANCEMENT OF DISSOLUTION RATE OF CIPROFLOXACIN BY USING VARIOUS SOLID DISPERSION TECHNIQUES
... Drug content of the samples was determined by Spectro 2080 plus Analytical technologies ltd UV Spectrophotometer at 288nm after suitable dilution of samples 11 . Necessary corrections were made for the loss of drug due ...
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ENHANCEMENT OF THE DISSOLUTION RATE OF NATEGLINIDE TABLETS USING LIQUISOLID COMPACT TECHNIQUE
... Its dissolution profile was compared with that of the marketed ...the dissolution profiles of optimized and marketed formulation it was concluded that optimized formulation was equally or better releasing ...
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ENHANCEMENT OF THE SOLUBILITY AND THE DISSOLUTION RATE OF CANDESARTAN CILEXETIL USING MICROSPONGE TECHNOLOGY
... The dissolution rates for the prepared microsponges formulae were carried out using USP paddle method at 50 rpm in 900 ml of phosphate buffer H ...a dissolution media, maintained at ...the ...
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Enhancement of Solubility and Dissolution Rate of Racecadotril through Solid Dispersion Methods.
... SOLID DISPERSION Page 11 to a reference standard) of the solvent by the use of co-solvents rather than the pH of the solvent. The use of salt forms is a well known technique to enhanced dissolution profiles. Salt ...
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ENHANCEMENT OF CANDESARTAN CILEXETIL DISSOLUTION RATE BY USING DIFFERENT METHODS
... enhanced dissolution rates of SDs may be due to many factors such as decreased particle size of drug, specific form of drug in these SDs, in addition to increase in drug wettability and preventing of drug ...
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Formulation Development and Evaluation of Poorly Water Soluble Gliclazide Tablet Containing Aerosil 380 as Carrier
... Gliclazide is a second-generation hypoglycemic sulfonylurea used in the treat- ment of type 2 diabetes [1] [2]. As a poorly water-soluble drug gliclazide possess drawback of low aqueous solubility [3] [4] [5], it is ...
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