Based on the literature and insights gained from discussion with our pharmaceutical distributor, we have devel- oped the following framework (Figure 1) to help supply chain professionals plan and prepare for a DC reloca- tion. This framework focuses on three decisions managers must address regardless of their industry. The first decision examines whether a DC shutdown is possible during the relocation. If another DC can service the cus- tomers or if customers have been given enough notice to plan their orders accordingly, then a DC shutdown is possible. When a DC shutdown is possible, managers need to determine the duration of the shutdown. The firm will then need to decide when they should begin shipping all incoming product to the new DC in advance of the relocation. Managers of the firm will also need to plan how the remaining product from the current DC will be moved to the new DC. The speed of this move will depend on the amount of product to be moved, labor and transportation constraints, and the cost of the move especially if it involves overtime or weekend pay additions. Mix  discusses how much shutdown time is practical. He suggests the shorter the shutdown, the longer the time to achieve smooth operations after the move. In one situation with a manufacturer’s distribution center, op- erations were shut down for nearly three weeks with stabilized smooth operations achieved relatively quickly. In another instance, with a distributor moving a much shorter distance, the move was made over a long weekend with a one-business-day shutdown but resulted in excessive overtime for two months afterward. The length of the shutdown will be strongly influenced by senior management, and rightfully so, as it affects all aspects of the business including marketing and sales.
the logistics activities are almost entirely carried out with the center, which is a very important node in the supply chain. The positioning of the distribution center almost determines the cost required for the distribution business. Scientific and rational location not only can save the future business costs, more importantly, is able to provide customers with high quality and efficient logistics services. Therefore, the location problem of the distribution center plays a very important role in the whole logistics system research, which mainly belongs to the research problem of the logistics management strategy level. Distribution center location, includes a single distribution center location and multiple distribution center location. This article discusses multiple distribution center location. To set the distribution center, the so-called distribution center location selects a certain number of location in a number of known sites, so that the total cost of forming the logistics network is minimal, which includes basic investment costs, variable fees and constant costs. For this type of problem, with the nature of NP-hard problems, should not use linear model to deal with. Therefore, its mathematical model is usually expressed in discrete form. Assuming there are 𝑛 demand points in the logistics network, it is necessary to set up m distribution centers, how to set the distribution center and their respective distribution range, so that the costs of the total distribution are the lowest. The planning models are as follows:
In the above mentioned literatures, these researches cannot be proceeded smoothly without the assumption that there are enough history data to obtain probability distribution which is closed to the real frequency. How- ever, sometimes the lack of history data posed difficulties for applying probability theory, especially when a new product was shipped to the customer by distribution center. In this case, we have to invite some experts to give the belief degree that each event will occur. In order to deal with belief degree, uncertainty theory was found by Liu  in 2007, which has become a new tool to describe the human uncertainty.
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According to the geographic location of steel company and the demand of steel in Hu- nan province, the location model of distribution center with minimum total transpor- tation cost was established by using accurate center of gravity method. The iterative so- lution was carried out by Matlab software. The conclusion can be seen by comparing the transport costs: from the steel mills in Wuhan to Hunan cities, the total transporta- tion costs greatly reduced after the establishment of distribution centers. In the direct transport, Wuhan steel logistics flexibility is poor and can’t fully focus on its core busi- ness; the cost is huge whose competitiveness is not good in the market. The establish- ment of steel logistics distribution center is to meet customer’s needs better and quickly adapt to market changes, and large-scale transportation can reduce costs, so the con- struction of specialized distribution center has broad prospects. The results of this study can be the decision-making basis for the iron and steel plant construction logis- tics center.
locations satisfying both of the mentioned conditions are the feasible next locations. Out of the feasible options, the neighbor with the lowest priority is chosen. The failure to find a next location results in the load being blocked and all the tagged loads to be reset. The load remains blocked until such time that the search procedures do not find an empty location in subsequent time steps. In cases where any of the neighbors shortlisted as feasible next locations are in a passive state (empty), such neighbors are preferred as the next location. Once a module is tagged as the next location, then it in turn searches for the next location and this iterative search procedure stops only when some module encounters an empty module as its next location. The common property between all the tagged modules is the inherited priority; all the tagged modules inherit the priority of the order load that initiates this procedure. Figure 6 details the Tagging Modules for movement process. The values at the bottom right corner indicate the location IDs; the values in the small squares at the top center indicate the inherited priorities and the numerical values at the center show the priority values of each module.
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The international division of production methods has changed dramatically and Taiwan's wireless industry has undergone a structural shift, including relocating their production lines to low-cost production countries, which has forced ACLPs to rethink the international configuration of service value to meet client’s demands. In order to handle logistics activities effectively and efficiently, companies generally have the choices of keeping logistics functions in-house, setting up or buying a logistics firm, or outsourcing to logistics companies (Razzaque and Sheng, 1998). After experiencing the 2008 financial crisis and the outward migration of industry, increasingly competitive pressures have forced ACLPs to transform their capabilities to meet a client’s logistics image. To achieve effective improvements in the aspects of logistics image considered in this study, it will be necessary to address the client’s lead-time for air cargo, production abroad, global distribution, and the role of international logistics. In addition to facilitating the outsourcing of a client’s global marketing and cargo logistics system, a distribution center adds value by providing a number of service attributes to shippers, such as storage, cargo tracking, inland transport service, customs clearance service, consolidation, packing, labeling, assembly, documentation service, and the overall service value from ACLPs (Lu, 2003).
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In this paper, key distribution for symmetric key cryptography is studied. Cryptography is a technique to convert a plain data in to non-readable form. We can convert the plain data into non-readable from using symmetric key cryptography. Symmetric cryptography uses only one secret key to encrypt and decrypt the data. To do the encryption and decryption in symmetric cryptography we need to share a key between two parties. The key can be distributed in different ways between two parties. If there is a point to point encryption the key can easily distributed, but if the key need be share in end to end encryption then we can use trusted third party to distribute the keys (key distribution center) between the sender and receiver. In a distributed network, there is also need for authentication of the client who requesting the services of a server. Many authentication and key distribution protocols are used; the main two are Needham-Schroeder key distribution protocol and Kerberos protocol. In Needham-Schroeder key distribution protocol, the key distribution center generates a number once used session keys to allow access to the server services by the client. By the number of the session key allotted by KDC, sever can identify the authorized work satiations. In Kerberos protocol, each session key generated by the Kerberos KDC server will have time stamp associated with it, so that after some time it is going to expire. The server can easily identify the authorized client by checking the validity of the session key.
The coding method directly arranged by the customer is adopted, that is, the customer randomly arranges according to the serial number without repetition, and the arrangement constituted by the customer constitutes a solution to the problem, that is, a distribution method is generated. Assume that there are 3 vehicles that need to deliver goods to 5 customers, so that the customer's arrangement is 32541. The delivery route can be obtained as follows: First, customer 3 is the first customer of the first vehicle service, combined with the first vehicle. The maximum load capacity and the maximum travel distance determine whether the customer 3 satisfies the condition. If it is satisfied, the customer who takes 2 as the second service also judges whether the condition is satisfied according to the maximum load capacity and the maximum travel distance of the vehicle, and if so, if it is not satisfied, try to find the next customer at a time. If it is not satisfied, return to the distribution center and serve the other customers by the next vehicle. With this representation method, it is possible to obtain a delivery route scheme in which the delivery scheme is smaller than the total number of vehicles. In addition, if all customers cannot be serviced, that is, the delivery vehicle cannot pass through all the customers, the solution is an infeasible solution.
Aimed at a cloud with various PSin a data center, an interesting direction of RA is how to attain efficient resource consumption . Study by Steiner et al. Examine the distribution of resources for various combinations of workloads and imagine a data center management mechanism to increase server resource consumption . D and Wang increase resource employment and optimal implementation efficacy by recommending a new system, DOPS. Cardoza et al. studying the effectiveness of using map resources reduces clouds . They offer a spatio-temporal compromise method for scaling a map, dynamically shrinking clusters to increase power consumption even though improving performance. George et al.  demonstrates a multi-tasking resource scheduling method for reducing the map, which develops RU when meeting runtime goals. Sunholm and Lau  present a RA system that uses user-defined preferences for threshold rental levels and dynamically adjusts RA to suit needs.
Water application uniformity is an impor- tant performance criterion for the design and evaluation of center pivot irrigation systems. System unifor- mity coefficient is a numeric judg- ment of the overall performance of an irrigation system's ability to evenly apply water to the field. However, the water application depth of a center pivot irrigation system is not usually uniform across a field as it depends on the sprinkler package, field topo- graphy, movement of the machine, and many other factors. In addition to that wind distortion of sprinkler distribution patterns is a major dynamic factor (Evans, 2001). The uniformity coefficient for the systems of the study was found to be 87% in NARC, 90% in AZRI (BWP) and 92% in TB Khan. The results of all locations were obtained in a range of 87 to 92%. According to Zoldoske et al. (1994), CU of AZRI (BWP) and TB Khan system lies in a range of excellent and only requires regular maintenance. Although the CU of NARC system is considered as good and does not need major adjustments but regular maintenance and inspection are re- quired. Therefore, CU of all the sys- tems is in good and excellent range.
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In order to demonstrate the applicability of the proposed model, a sample problem is developed and solved via GAMS 23.6 by using CUENNE solver and the numerical results are then analyzed. There are various suppliers in this problem based on quality of which different costs are provided for supply of raw materials. Moreover, manufacturing, distribution, collection, repair and disposal centers are considered as potential sites that only after the solution of model would it be possible to specify which of these potential centers may either be closed or open. Furthermore, customer and supply centers are predetermined. Other relevant data are explained in table (2).
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The FPGA designs of all three cryptographic operations consist of three main components: matrix-matrix multiplication, addition of an error distribution, and the use of random oracles via cSHAKE. Our designs use two cSHAKE modules and one AES module. Essentially all the designs proposed have the same critical path, that is, the matrix-matrix multiplications. All other modules, such as random number generation, occur in parallel to this which saves significant clock cycles and simplifies the overall design. This also means the clock cycles per operation are easily calculable and, more importantly, happen in constant time, where for example, encapsulation happens in ˆ n × (n × n ˆ + ˆ n × n) clock ˆ cycles. Efficient constant runtime is a practical countermeasure to some simple side-channel attacks such as timing analysis.
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de Rescate y Conservación de Vida Silvestre and its staff; Consejo Nacional de Áreas Protegidas Suroriente; Dirección de Normatividad de la Pesca y Acuicultura del Ministerio de Agricultura, Ganadería y Alimentación; Ministerio de la Defensa Nacional; and Protortugas, Guatemala. We also thank the support of the communities of Barra del Jiote and Hawaii, many donors (Hotel Hawaian Paradise, Hotel Honolulu, Guatemala Unida por los Animales, Universidad Rafael Landivar, Universidad del Valle de Guatemala, Universidad de San Carlos de Guatemala, Clínica Veterinaria San Cristóbal) and volunteers for their invaluable assistance, and those who helped to organize and secure the release of the Galapagos fur seal at CONAPAC. Lastly, we thank the invaluable support provided by local and foreign veterinarians and pinniped specialists (alphabetic order): Carlos Alfaro (Protortugas, Guatemala), Daniela Bárcenas (Universidad Autónoma de Baja California Sur, México), Fernando Elorriaga-Verplancken (Centro Interdisciplinario de Ciencias Marinas, México), Sophie Guarasci (The Marine Mammal Center, U.S.), Diego Páez-Rosas (Universidad San Francisco Quito, Ecuador), Jaime Pérez (Protortugas, Guatemala), Claire Simeone (The Marine Mammal Center, U.S.), Stella Villegas (University of California, Santa Cruz, U.S.), and Carlos Yaipén-Llanos (Organización Científica para la Conservación de Animales Acuáticos, Peru). We thank Juan J. Alava, Ruben Montano-López, Claire Simeone and one anonymous reviewer for valuable comments on the manuscript. Kerri Scolardi prepared the figure of the study area. This work is dedicated to Francis, the Galapagos fur seal described in this article.
Unfortunately, the above assumptions have not been investigated in the study of risks associated with metals-loaded dust in Nigeria cities. This report will fill such a gap. The study is part of the Urban Dust Monitoring and Health Risk Assessment (UDMAHRA) project, initiated to monitor urban dust and its potential health risks in Nigerian cities. As studies continued to unravel the characteristics and potential health risks of dust in urban atmosphere, the aim of this contribution was to investigating the relative bioavailability and toxic potentials of some heavy metal contents of suspended dust samples in a fast growing city (Akure: 7˚10ʹN and 5 ˚ 15 ʹ E). The objectives of this study include (i) assessing the particle size distribution of dusts of the monitoring sites, (ii) evaluating the bioavailability of metals-loaded dust samples collected in atmosphere of Nigeria city, and (iii) assessing the carcinogenic and non-carcinogenic toxicity potentials of the metals on the basis of the relative content of the fractions. The novelty of this study is that we attempt to incorporate adjusted relative bioavailability to human health risk assessments. It is envisaged that the data generated in this study will stimulate environmental concerns on the impacts of dust particles and be translated into improved respiratory health among the people. Materials and Method
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) which contribute to both cortical and subcortical telencephalic neurons, and whose distribution/dispersion is restricted by Fgf signaling. Surprisingly, Fgf8 + and Fgf17 + progenitors generate most of the cholinergic neurons in the basal ganglia. The mosaic distribution of Fgf8 + and Fgf17 + progenitors in the telencephalon VZ suggests that they are interspersed with progenitor subtypes of different origins. This provides novel insight into a mechanism that may underlie regional growth and cellular complexity in the forebrain. To fully appreciate the significance of our find- ings, we need a greater understanding of how heteroge- neous progenitor subtypes differentially contribute to forebrain development and function. Future studies using our CreER knock-in lines could begin to address these questions by labeling, isolating, and characterizing different telencephalon progenitor subpopulations.
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Generally, the mortality rate due to non- penetrant trauma is far more than penetrating trauma, and despite new and applied diagnostic methods such as CT scan, damage to any medical device is still a complicated issue (14). Considering the high rates of injuries caused by driving accidents in Mazandaran province and imposing heavy costs on patients and the health system, and the need for accurate statistics and information for future planning and targeting, and the lack of specific epidemiological studies for injuries caused by driving accidents, studying to respond to this need was felt. In this study, we evaluated the frequency of injuries caused by driving accidents in patients referred to the emergency department of the Sari hospital from April 2014 to April 2016, over a period of 2 years, to improve preventive and remedial planning with the help of this information in the future. It should also be noted that due to the lack of such information in this center and the high distribution of clients with driving accidents, such a project has been of particular
The larger number of responses at high angles by P. violacea may indicate a difference in signal characteristics used to direct behavior. These rays often entered the electric field but continued on a straight trajectory until they reached the steep gradient drop near 90 deg. from the dipole axis. By contrast, U. halleri and M. californica appeared to respond more frequently to an increasing electric field, making a single turn or adding a second turn to reach the center (Table 3). Pteroplatytrygon violacea overshot the center of the electrode much more frequently and then reversed their trajectory to swim backwards to position the mouth over the dipole center. There are several possible explanations for this behavior: (1) accuracy may be reduced due to the lower pore number and density; (2) movement of prey targets may be anticipated as they typically feed on fast moving, pelagic prey; or (3) these movements may have been exaggerated due to the larger size and slower movements of P. violacea individuals. Because all rays were
This is not only the largest group, but also the only group for which the inventory level is actually too low if one wants to achieve a target fill rate of 98%. Currently, the inventory is a factor 1.2 too low. There are two important issues. Firstly, there is much difference between the SKU’s in this group. Some are relatively fast, others very slow. What’s more, is that this means that to control such a large group, there is more work needed. The compound Poisson probability distribution used to construct the rLTD distribution can still be used, but a strategic decision should be taken here and this decision is yet to be researched: should TU invest in inventory to reach a higher fill rate, or should the fill rate be lowered for some products so that the costs are cut. Apart from that, the compound Poisson probability distribution method can still be used to determine the reorder points for items in this group.
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However, regarding liberal parties that are located at the center of the party spectrum, evidence is much more manifold and no explicit indication of their positioning on immigration issues is made. Due to the fact that the liberal group in the EP, i.e. the Alliance of Democrats and Liberals for Europe (ALDE), is in favor of protecting minorities "involving citizens from all ethnic backgrounds ensuring safe and legal entry possibilities" (ALDE, 2015), this EPG is generally seen as moderately in favor of more open immigration policies. However, as liberal parties are considered to form the most ideologically diverse and heterogenic of the major party families and European liberalism, unlike the rest of the party families, is rooted in a variety of cleavages that according to Marks et al. (2000) arose out of the urban-rural cleavage (GB; GER in the 19th century), the state-church cleavage taking an anti-clericalism and pro-capitalism stance (FR; IT; ESP), and the center-periphery cleavage (Nordic countries in 20th century) favoring progressive politics, that are often anti-authoritarian and relatively liberal-radical. Whereas for instance the Dutch VVD takes a liberal-conservative position concerning immigrant integration, emphasizing economic freedoms and thus tends to be located right-of-center, the Danish Venstre Party and Dutch D66 support liberal-radicalism favoring social justice and opposing nationalism, which is why they are considered to take an open position towards immigrant integration. 5 A study by McElroy et al. (2011) proves that in terms of the overall diversity of positions
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At last, we propose a AHP- GP material flow based on center location model. This model is mainly suitable for the constraint. Under the condition of limited resource, we will optimize the combination of a plurality of logistics center location. When the constraints of the resource become large, the model accuracy and rationality will decrease. The selection of Logistics center location is a very complex issue, and involves legal, regulations, planning, land use rights, logistics business category, logistics facilities, financing ability, traffic environment, natural conditions and other factors [1-5]. Therefore, logistics center location need to be decided by combining qualitative analysis and quantitative analysis together, or by using integrated methods In the construction, we will often use a combination of qualitative and quantitative analysis of analytic hierarchy process(Analytic Hierarchy Process, AHP) [6 ,7].