endothelial cell dysfunction
Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium
... mediator of endothelial dysfunction and CAD? We need to closely follow this debate before reaching a final conclusion. Caution must also be applied to in vitro studies with human recombinant CRP, as it has ...
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Pro-inflammatory endothelial cell dysfunction is associated with intersectin-1s down-regulation
... hepatocytes, ECs [28,29]. A mitochondrial NOS, mtNOS, constitutively expressed, continuously active and associated with the inner mitochondrial membrane has been reported [21,30]. LPS-induced up-regulation of ...
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Endothelial cell markers reflecting endothelial cell dysfunction in patients with mixed connective tissue disease
... anti- endothelial cell antibodies (AECAs) ...of endothelial cells ...the endothelial cells. TM - an endothelial high-affinity receptor for thrombin - has an anticoagulant effect, ...
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Bench to bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?
... (12.0 ± 1.6 versus 7.1 ± 1.2; P = 0.026). An increase in circu- lating ECs can therefore be identified during sepsis and septic shock. That study was among the first to support the hypothesis that endothelial ...
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Original Article Long non-coding RNA MEG3 mediates high glucose-induced endothelial cell dysfunction
... locus located on chromosome 14q32 in hu- mans [13]. Previous studies showed that MEG3 is expressed in normal human tissue. However, the loss of MEG3 expression has been found in various types of human tumors, including ...
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Cellular and molecular mechanisms of endothelial cell dysfunction
... Another factor that may affect endothelial NO production in various pathophysiological conditions is the level of expression of the eNOS enzyme. Although eNOS is constitutively ex- pressed, both in vivo and in ...
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Aldose reductase mediates endothelial cell dysfunction induced by high uric acid concentrations
... HUVECs UA (300 μM) reduced total ROS levels in endothelial cells, whereas high UA (600 μM) treatment increased intracellular ROS production (Fig. 1a). NO re- lease was reduced after high UA treatment in vitro with ...
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Original Article Roles of claudin-5 and von Willebrand factor in patients with rheumatoid arthritis
... that endothelial function is associated with the proinflammatory state of ...RA. Endothelial dysfunction/activation reflects the increased level of von Willebrand factor (vWF) and a shift toward ...
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Original Article SIRT3 protects endothelial cells from high glucose-induced cytotoxicity
... society. Endothelial cells dysfunction was involved in the development of diabetes-associated ...diabetes-associated endothelial cell dysfunction was relatively ...glucose-induced ...
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Is type 2 diabetes mellitus a vascular disease (atheroscleropathy) with hyperglycemia a late manifestation? The role of NOS, NO, and redox stress.
... Could it be that one of the polygenic causes of T2DM in- volve the eNOS enzyme? Such as one or more gene poly- morphisms resulting in a defective but functioning eNOS enzyme. This would certainly help to explain the ...
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Preeclampsia: long-term consequences for vascular health
... stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vas- cular cell adhesion molecule type ...
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α2AP regulates vascular alteration by inhibiting VEGF signaling in systemic sclerosis: the roles of α2AP in vascular dysfunction in systemic sclerosis
... vascular endothelial cad- herin, GAPDH, phospho-VEGFR2, VEGFR2, phospho- Akt, Akt, phospho-ERK1/2, ERK1/2, phospho-p38, p38, phospho-SHP2, SHP2, and ATGL by incubation with the respective antibodies followed by ...
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Evidence based antioxidant activity of the essential oil from Fructus A zerumbet on cultured human umbilical vein endothelial cells’ injury induced by ox LDL
... The MTT assay utilizes the yellow MTT, which is metabo- lized by the mitochondrial succinate dehydrogenase to yield a purple formazan reaction product. Exposure of endothe- lial cells to 100 mg/L ox-LDL for 24 h ...
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Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment
... inhibit endothelial proliferation, blunt angiogenesis, and be a cardioprotective ...vein endothelial cells (HUVEC) treated in a diabetic-like environment with the addition of ...
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Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig
... Furthermore, endothelial function of pulmonary arteries in healthy smokers lies between that in non-smokers and COPD patients, thereby indicating that endothelial dysfunction is present at the origin ...
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EFFECT OF RUBIA CORDIFOLIA ALONE OR AS AN ADJUVANT WITH ATORVASTATIN IN EXPERIMENTAL HYPERLIPIDEMIA AND ATHEROSCLEROSIS
... Recent studies have indicated that the cholesterol or methionine-enriched diet induced elevation in BP. [40, 63] This observation was consistent with the observed alteration mean BP by feeding the rats with [C+M] diet. ...
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The Ras activator RasGRP3 mediates diabetes-induced embryopathy and ET1-induced vessel morphogenesis
... endothelial cells were grown to 60% confluence, serum-starved in 0.1% FBS/EBM-2 media overnight, then left untreated or treated with 100 nM PMA, 5 nM VEGF-A, or 100 nM ET1 diluted in 0.1% FBS/EBM-2 medium for 30 ...
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Endothelial dysfunction in patients with Buerger disease
... However, the present study has several limitations. First, direct comparisons between Buerger disease patients and healthy subjects might more concretely confirm the clinical significance of PAT. Furthermore, the ...
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Endothelial Dysfunction in Systemic Lupus Erythematosus.
... Endothelial dysfunction appears when the normal functions of the endothelial cells (control of vascular tone and blood pressure, regulation of leucocytes traffic from the blood to the tissues, and ...
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GLP-1 treatment protects endothelial cells from oxidative stress-induced autophagy and endothelial dysfunction
... The cells were treated with different conditions respectively. Following 30 min fixation in 4 % paraformaldehyde, they were washed with PBS, and then permeabilized with 0.5 % Triton X-100 in PBS. After washing with PBS ...
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