Gene and Environment
Design and analysis issues in gene and environment studies
... of environment retro- spectively is fraught with potential recall ...of gene-environment interactions will not be sub- ject to selection bias if participation does not differ by genotype conditional ...
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Interaction between ELMO1 gene polymorphisms and environment factors on susceptibility to diabetic nephropathy in Chinese Han population
... between gene and environment factors were associated with the DN ...elmo1 gene polymorphism and environmen- tal factors on DN ...significant gene–alcohol drinking interaction combination, but ...
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Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example
... candidate gene studies, genome-wide linkage screens followed by positional cloning studies and more recently genome- wide association studies (GWAS) ...the environment are not taken into ac- count, or if ...
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Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease
... the environment might be even more pronounced in patients whose phenotypes are caused by the aggregation of small contributions from many genetic and non-genetic ...replicated gene-gene and ...
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Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development
... A genetic contribution to refractive error has been confirmed by the discovery of more than 150 associated variants in genome-wide association studies (GWAS). Environmental factors such as education and time outdoors also ...
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Comparison of 2 models for gene–environment interactions: an example of simulated gene–medication interactions on systolic blood pressure in family based data
... complementary gene–environment (G × E) interaction methods have been described in the lit- erature to test G × E interactions such as differential response to antihypertensives resulting from genetic ...a ...
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Gene × gene and gene × environment interactions for complex disorders
... BioMed CentralBMC Proceedings ss Open AcceProceedings Gene ? gene and gene ? environment interactions for complex disorders Robert Culverhouse*1, Anthony L Hinrichs2, Carol H Jin2,3 and Brian K Suarez[.] ...
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Gene-environment interactions and obesity: recent developments and future directions
... and environment factors in the development of ...examining gene and dietary intervention interactions for weight loss and main- tenance [8,23,24,41], but there are still many ...
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Original Article Methylenetetrahydrofolate reductase gene A1298C polymorphism and gene-environment interactions are associated with carotid plaque in a south Chinese population
... MTHFR gene A1298C polymorphism in combi- nation with certain conventional risk factors and CP risk could explain the observed gene- environment ...
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Gene-Environment Interaction in Type II Diabetes
... is gene-environment ...and environment factors have been significantly associated with type 2 ...that gene-environment interaction can significantly increase the chances of progression ...
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CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits
... This gene resides within a region identified as having been subject to a selective sweep in Ethiopian highlanders with respect to hypoxia tolerance adaptation ...
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Regulation of bacterial virulence gene expression by the host environment
... February 1, 1997 Arthropod- and host-specific gene expression by Borrelia burgdorferi ................................................. Aravinda M. de Silva ...
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Gene Environment Interactions in Asthma: Genetic and Epigenetic Effects
... candidate gene polymorphism studies, and genome-wide association studies ...a gene and the environment is a candidate interaction of both a well known gene and envi- ronmental factor in a ...
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Extraction of Gene Environment Interaction from the Biomedical Literature
... the gene-disease relation is sen- sitive to external factors, their identifica- tion is important to study a ...called Gene-Environment interaction (GxE), have been considered as impor- tant factors ...
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Interpreting Coronary Artery Disease Risk Through Gene–Environment Interactions in Gene Regulation
... arbitrary environment, and thus it is necessary to annotate regulatory regions across multiple ...of gene expression, such as RNA-seq, provides insights into the reg- ulatory code governing gene ...
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Operating Characteristics of Statistical Methods for Detecting Gene-by-Measured Environment Interaction in the Presence of Gene-Environment Correlation under Violations of Distributional Assumptions
... In the past few decades, it has become increasingly clear that any inquiry into the roots of psychopathology such as anx- iety or depression, as well as other complex behaviors, re- quires accounting for possible ...
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Comparison of the power of haplotype based versus single and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis
... analyzing gene × environment (gene × sex) interactions was compared using the Genetic Analysis Workshop 15 (GAW15) simulated data on rheumatoid arthritis with prior knowledge of the ...
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A model of gene-gene and gene-environment interactions and its implications for targeting environmental interventions by genotype
... The model shows that the potential for reducing the inci- dence of common diseases using environmental interven- tions targeted by genotype may be limited, except in special cases. The model also confirms that the impor- ...
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Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies
... At the model level, the RIPPER algorithm outperformed the other two evaluated algo- rithms. RIPPER discovered the true model (grade “A”) or a slight variation of the true model (grade “B”) >40% of the time with ...
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Testing gene environment interactions in gene based association studies
... (one gene at a time) and found that the quadratic and Gaussian kernels produced consistent results but that the quadratic kernel was com- putationally much ...a gene-environment interaction effect ...
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