Gene environment
Gene × gene and gene × environment interactions for complex disorders
... BioMed CentralBMC Proceedings ss Open AcceProceedings Gene ? gene and gene ? environment interactions for complex disorders Robert Culverhouse*1, Anthony L Hinrichs2, Carol H Jin2,3 and Brian K Suarez[.] ...
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Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development
... A genetic contribution to refractive error has been confirmed by the discovery of more than 150 associated variants in genome-wide association studies (GWAS). Environmental factors such as education and time outdoors also ...
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A novel approach to simulate gene environment interactions in complex diseases
... We implemented the MLM in the Gene-Environment iNteraction Simulator, a GxE simulator for case-control studies. The intended audience of GENS is the biomedi- cal community, thus the main efforts have been ...
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Gene-Environment Interactions and Airway Disease in Children
... candidate gene studies may reflect inaccurate phenotyping of ...specific environment-gene-asthma phenotype combina- ...specific gene-environment interactions have defined the ...
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Gene-Environment Interaction in Type II Diabetes
... of gene-environment interaction has been found to vary with the field of diabetes research, yet the epidemiological definition of this interaction can be adopted for the purpose of this ...word ...
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Original Article Methylenetetrahydrofolate reductase gene A1298C polymorphism and gene-environment interactions are associated with carotid plaque in a south Chinese population
... (MTHFR) gene polymorphisms with the risk of carotid plaque in a south Chinese ...explore gene-environment interactions and potential relationship with carotid ...MTHFR gene polymorphisms and ...
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Gene-environment interactions and obesity: recent developments and future directions
... set-based gene environment interaction test (SBERIA) Jiao et ...set-based gene environment inter- action test (SBERIA) to explore the GEI using case-con- trol data ...
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Comparison of 2 models for gene–environment interactions: an example of simulated gene–medication interactions on systolic blood pressure in family based data
... complementary gene–environment (G × E) interaction methods have been described in the lit- erature to test G × E interactions such as differential response to antihypertensives resulting from genetic ...a ...
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Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease
... the environment might be even more pronounced in patients whose phenotypes are caused by the aggregation of small contributions from many genetic and non-genetic ...replicated gene-gene and ...
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The impact of imprecisely measured covariates on estimating gene-environment interactions
... a gene-environment interac- tion in the situations described, so if the primary goal of a study is estimating the gene-environment interaction, measurement error in a confounder is of lesser ...
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Comparison of the power of haplotype based versus single and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis
... of gene × environment interaction terms in association analyses may improve the power to detect genetic effects and may contribute to the identification of important environmental effect modifiers ...for ...
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Gene Environment Interactions in Asthma: Genetic and Epigenetic Effects
... the environment. Al- though the concept of gene-environment (GxE) interactions emerged in the 19th century, investigation of GxE interac- tions has been mainly limited to candidate genes or candi- ...
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CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits
... the gene-environment interaction [9]. A gene- environment interaction refers to modification by an environmental factor of the effect of a genetic variant on a phenotypic trait ...
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Extraction of Gene Environment Interaction from the Biomedical Literature
... the gene-disease relation is sen- sitive to external factors, their identifica- tion is important to study a ...called Gene-Environment interaction (GxE), have been considered as impor- tant factors ...
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A model of gene-gene and gene-environment interactions and its implications for targeting environmental interventions by genotype
... The four-category model of population risks developed by Khoury and others [19] is a useful starting point for a top- down analysis of genetic prediction and prevention. It allows the merits of a targeted intervention ...
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Testing gene environment interactions in gene based association studies
... of gene-environment interac- tion using the GAW17 simulated ...a gene, as we demonstrated in our ...one gene is simulated with a gene-environment interac- ...
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Predictors of patient uptake of colorectal cancer gene environment risk assessment
... combination gene-environment test to AAs and expressed interest and consent to be in the study, we believed that actual GERA testing uptake would be less than in white participants, similar to the low ...
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Gene-Environment Interaction in Chronic Disease
... The identification of genetic or epigenetic asso- ciations with disease phenotypes facilitates risk stratification and can therefore help to guide mon- itoring and prevention. In order to convert these observations into ...
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Gene environment interaction impacts on heart development and embryo survival
... a gene-environment interaction (GxE) between genetic predisposition to vertebral segmentation defects and short- term gestational hypoxia (Sparrow et ...
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Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies
... At the model level, the RIPPER algorithm outperformed the other two evaluated algo- rithms. RIPPER discovered the true model (grade “A”) or a slight variation of the true model (grade “B”) >40% of the time with ...
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