genome integrity
Nucleotide excision repair : a multi-step mechanism required to maintain genome integrity
... genome integrity is continuously challenged by various sources that potentially damage ...the genome (de laat et ...global genome Ner ...the genome (de laat et ...
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The Mitochondrial Genome Integrity Gene, MGI1, of Kluyveromyces lactis Encodes the β-Subunit of F1-ATPase
... lactis, we named these nuclear genes MGI for mitochondrial genome integrity because we imagined that their function could be to prevent ectopic recombination in mtD[r] ...
10
Phosphorylation of Herpes Simplex Virus 1 dUTPase Regulates Viral Virulence and Genome Integrity by Compensating for Low Cellular dUTPase Activity in the Central Nervous System
... Effect of the vdUTPase S187A mutation on the mutation fre- quency in progeny viral genomes in cell cultures and mouse CNS. To examine whether Us3 phosphorylation of vdUTPase Ser-187 was involved in regulation of viral ...
8
miR146a-mediated targeting of FANCM during inflammation compromises genome integrity
... miR146a directly targets the 3ʹUTR of FANCM It is becoming well-accepted that inflammation- induced miR146a is associated with cancer development [4–6, 26]. Our initial analysis of miR146a showed that its overexpression ...
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The replicative histone chaperone CAF1 is essential for the maintenance of identity and genome integrity in adult stem cells
... Chromatin packaging and modifications are important to define the identity of stem cells. How chromatin properties are retained over multiple cycles of stem cell replication, while generating differentiating progeny at ...
13
Transcription Factor RFX1 Is Crucial for Maintenance of Genome Integrity in Fusarium graminearum
... The survival of cellular organisms depends on the faithful replication and transmission of DNA. Regulatory factor X (RFX) tran- scription factors are well conserved in animals and fungi, but their functions are diverse, ...
10
CSN6 deregulation impairs genome integrity in a COP1- dependent pathway
... of genome integrity with increased chromosomal breakages (Figure 5F, Table 1), suggesting that the COP1-p27-Aurora A axis may play a role in genome ...
15
Drosophila mitochondrial topoisomerase III alpha affects the aging process via maintenance of mitochondrial function and genome integrity
... There are two well-documented mitochondrial topoi- somerases in mammalian cells, Top1mt (mitochondrial topoisomerase I) [38] and Top3α [39]. Top1mt is encoded in the nuclear genome and imported into mito- chondria ...
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Mitotic Accumulation of Dimethylated Lysine 79 of Histone H3 Is Important for Maintaining Genome Integrity During Mitosis in Human Cells
... of genome instability and ...with genome instability (Chernikova et ...in genome stability will provide new insight into the mechanisms re- quired to maintain genome ...
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Maintenance of Genome Integrity by Mi2 Homologs CHD-3 and LET-418 in Caenorhabditis elegans
... ABSTRACT Meiotic recombination depends upon the tightly coordinated regulation of chromosome dynamics and is essential for the production of haploid gametes. Central to this process is the formation and repair of meiotic ...
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Maternal Haploid, a Metalloprotease Enriched at the Largest Satellite Repeat and Essential for Genome Integrity in Drosophila Embryos
... paternal genome into the ...in genome mainte- nance but opens an exciting avenue of using Drosophila MH to understand the paternal genome remodeling process during early animal ...
11
DNA Methylation, Its Mediators and Genome Integrity
... the genome during development and for newly inte- grated retroviral sequences [48, ...of genome-wide demethylation in the preimplantation embryo, Dnmt3a and Dnmt3b are highly expressed at implantation and ...
14
A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity
... ABSTRACT The protein phosphatase 2A (PP2A) is a conserved heterotrimeric enzyme that regulates several cellular processes including the DNA damage response and mitosis. Consistent with these functions, PP2A is mutated in ...
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Iron-sulfur cluster protein NITROGEN FIXATION S-LIKE 1 and its interactor FRATAXIN function in plant immunity
... Luo D, Bernard DG, Balk J, Hai H, Cui X (2012) The DUF59 family gene AE7 acts in the cytosolic iron-sulfur cluster assembly pathway to maintain nuclear genome integrity in Arabidopsis Pl[r] ...
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The CDK-resistant pRB-E2F1 complex recruits chromatin-organizing proteins to repetitive DNA sequences
... Since repetitive element expression remains suppressed throughout the cell cycle, a repeat-silencing mechanism must be resistant to fluctuations in cell cycle phase. An interaction between the pRB C-terminus and the E2F1 ...
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VOLUNTARY DISCLOSURE OF CORPORATE INTEGRITY IN THE ANNUAL REPORT OF THE MALAYSIAN FEDERAL STATUTORY BODIES
... the integrity disclosures ...on integrity disclosures in the context of public sector organization in ...corporate integrity disclosure in companies has been done by Arshad (2013a, ...corporate ...
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CRISPR Technology Challenge Facing the Numerical Integrity of Whole Human Genome DNA
... Diversity of Chromosomes from 3 Human Genomes The Chromosomes UPSTREAM the HGO theoretical point = 0.6909830056; Neanderthal, Sapiens 2003 Build34, Sapiens 2013 HG38 In the following, we demonstrate a real interaction, a ...
6
HITB-Ezine-Issue-002.pdf
... mandatory integrity control is an important ad- vance in maintaining the security and stability of Windows ...figuring integrity level were provided, many people would find the feature and start researching ...
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Directed genome engineering for genome optimization
... non-selectable genome editing ...plants, genome editing of non-selectable genes will only be possible by using multicellular tissue culture ...where genome editing may have happened. Once ...
8
“Philosophical Treatises on Life and Death”:Newspaper Coverage of a Controversial Brain Death Case
... possesses integrity, it usually means that he does not have the morally vicious commitments or principles that other people would obnoxiously disagree ...that integrity implies morality in general and that ...
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