Human telomerase reverse transcriptase (hTERT)
Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding Sites
... High-risk human papillomaviruses (HPVs) immortalize keratinocytes by disrupting the retinoblastoma protein (Rb)/p16 pathway and activating ...induces telomerase activity in human ...activates ...
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Human telomerase reverse-transcriptase promoter-controlled and herpes simplex virus thymidine kinase-armed adenoviruses for renal cell carcinoma treatment
... using human telomerase reverse transcriptase (hTERT)-controlled herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) in the hTERT promoter-driven HSV-TK/ GCV suicide ...
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Original Article Screening and identification of antisense accessible sites of the human telomerase reverse transcriptase gene in prostate cancer cell lines
... the human telomerase reverse transcriptase (hTERT) gene in prostate ...total hTERT complementary RNA (cRNA) that had been transcribed in ...total hTERT cRNA was cut into ...
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Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase
... overexpressing human telomerase reverse transcriptase (hTERT) for the treatment of ...with hTERT (EPCs-hTERT). EPCs-hTERT secreted more growth factors and ...
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Expression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells
... called telomerase to solve this ...active telomerase adds up some nonfunctional DNA repeats to the telomeric ends, to keep the critical length of DNA during multiple cell divisions ...of telomerase ...
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HTLV 1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT)
... the hTERT promoter To examine the role of HBZ in regulating the activity of the hTERT promoter, luciferase assays were performed with reporter plasmids containing various lengths of the 5' flanking sequence ...
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Diverse regulatory manners of human telomerase reverse transcriptase
... regulates hTERT in various ways. The hTERT peptide ( 817 AVRIRGKSYV 826 ) could be phosphorylated by the activated AKT kinase in vitro, which plays a cru- cial role in maintaining the telomere length and ...
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Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas
... of hTERT mRNA and p38 MAPK was performed with the Light- Cycler TaqMan Master using the LightCycler instru- ment (Roche Molecular System, Alameda, ...for hTERT, and 5’-ATGCCGAAGATGAACTTTGC-3’ and 5’- ...
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The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
... man telomerase reverse transcriptase (hTERT) gene ...The hTERT gene being the key component of telomerase catalytic activity, encodes the reverse transcriptase com- ...
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Original Article MicroRNA-138 suppresses cell proliferation of human malignant melanoma cells by targeting hTERT
... in human malignant melanoma (MM) are still poorly ...identified human telomerase reverse transcriptase (hTERT) as a direct target gene of miR-138, and demonstrated that the ...
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Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
... 1989, telomerase activity was reported for the first time ...of telomerase was only identified and functionally characterized in 1997, more than a decade after its discovery ...repeats. Telomerase is ...
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Switching of mesodermal and endodermal properties in hTERT-modified and expanded fetal human pancreatic progenitor cells
... = human embryonic stem cells; HNF = hepatic nuclear factor; hTERT = human telomerase reverse transcriptase; hTERT-FPC = human telomerase reverse ...
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Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer
... follows: human telomer- ase RNA ( hTR ): 5 ’ -cgccttccaccgttcattc-3 ’ (sense, 400 nM), 5’-gctgacagagcccaactc-3’ (antisense, 400 nM), 5’-FAM- agctgctggcccgttcgccc-TAMRA-3’ (TaqMan Probe, 200 nM); human ...
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Targeting Human Telomerase RNA via Biochemical and in vitro Selection Methods
... normal human cells there is little or no telomerase activity, whereas in 80% to 90% of tumor cells there is active enzyme (Neidle and Parkinson ...of telomerase in cancer is highlighted by its role ...
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The MNS16A Tandem Repeats Minisatellite of Human Telomerase: Influence on Polycythaemia Vera susceptibility in Sudanese Patients
... Background: Telomerase is a reverse transcriptase enzyme that can elongate the TTAGGG repeats of telomeres in cells, where it is expressed to sustain cellular ...of telomerase include RNA ...
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Original Article The functional TERT MNS16A polymorphic tandem repeat minisatellite contributes to gliomas development
... 2]. Telomerase is a cellular ribonu- cleoprotein with a rate-limiting determinant of the reverse transcriptase activity which main- tenance of telomeric repeats at the end of ch- romosomes ...[3-5]. ...
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Original Article TERT rs2736098 polymorphism and bladder cancer risk: a meta-analysis
... the human telomerase reverse transcriptase (TERT) gene variant rs2736098 polymorphism and bladder cancer risk, but the sample size has been small and the results were ...
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Alternative splicing and extra-telomeric role of telomerase reverse transcriptase isoforms in human embryonic stem cells
... of hTERT expression is orchestrated by several transcription factors and DNA/histone modifying complexes at the promoter ...for telomerase DNA binding and association with hTERC [113], [123, 124] was found ...
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Post-transcriptional regulation of telomerase reverse transcriptase (TERT) in human embryonic stem cells cultured under varying oxygen microenvironments
... Many human genes are known to be alternatively-spliced in response to hypoxia, and in some cases this process has appear to be regulated by HIF1 (Hang et ...
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Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma
... of human gen- ome with important regulatory effects on the gene expres- sion in cancer ...of telomerase reverse transcriptase (TERT) gene in about 85% of human tumors, including liver ...
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