Huperzine A
The pharmacology and therapeutic potential of (-)-huperzine A
... The manifold pharmacological effects of ( - )-huperzine A (1), especially when considered in the context of its favorable toxicity profile, argue for its development for the treatment of neurological disorders. ...
11
New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease
... Acknowledgment. Fellowships from Comissio´ In- terdepartamental de Recerca i Innovacio´ Tecnolo`gica (CIRIT) of the Generalitat de Catalunya to J. Morral, from Agencia Espan ˜ ola de Cooperacio´n Internacional (Instituto ...
10
Conformational Flexibility and the Interaction of Huperzine A in the Active Site of Acetylcholinesterase: A Quantum Chemical and Charge Density Study
... (-)-Huperzine A (Scheme 1) is one of the reported inhibitors of AChE [1]. It is an alkaloid isolated from the club moss [1‒10] Huperzia serrata and used as a Chinese herbal medicine. The pharmacologic studies ...
22
Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease
... Intranasal delivery of huperzine a to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of alzheimer’s disease.. Qingqi[r] ...
14
Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease
... A-like binding modes, which in some cases (modes 5 and 7) lead to better interaction of the ( + )-enantiomer. In contrast, modes 1 and 3 provide the largest binding free energy differences and clearly distinguish the ...
16
ANXIOLYTIC AND MOTOR COORDINATION ACTIVITY OF HUPERZINE A IN RATS
... Thin Layer Chromatography (TLC): Silica gel plates having size 2.5×7.5 cm. Chloroform/ acetone/water (1.0:1.5:1.5) used as developer and 0.3%potassium permanganate solution used as a color reagent. Huperzine-A ...
7
Original Article Huperzine A protects neural stem cells against Aβ-induced apoptosis in a neural stem cells and microglia co-culture system
... To evaluate effects of microglial cells on the survival of NSCs before and after microglial cells were activated by Aβ1-42, for NSCs group, NSCs were cultured on a Transwell insert and m[r] ...
9
Ultrastructural mitochondria changes in perihematomal brain and neuroprotective effects of Huperzine A after acute intracerebral hemorrhage
... Aim: The purpose of the study was to observe the ultrastructural changes of neuronal mitochondria in perihematomal brain tissue and assess the therapeutic potential of Hup[r] ...
9
Identification of the optimal cognitive drugs among Alzheimer’s disease: a Bayesian meta-analytic review
... Table 1 presents the baseline data of demographic charac- teristics from 35 trials included. A total of 9,820 AD patients underwent Population, Intervention, Outcomes strategies. The ChEI group holds an overwhelming ...
13
Compound danshen tablet ameliorated aβ25 35 induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins
... zine A), D-large dose of Compound Danshen Tablets group (LCDT) and E-small dose of Compound Danshen Tablets (SCDT) group. The mice in the large (LCDT), and small dose groups (SCDT) were administrated orally with doses of ...
10
Traditional Chinese medicine: a promising candidate for the treatment of Alzheimer’s disease
... Huperzine A (HupA) is an extract of Huperzia serrata, it has been used for centuries in China to treat fever, swelling, and blood disorders. HupA is a potent, revers- ible, and selective inhibitor of acetylcholine ...
7
2011-Potter-Yukon-Yenisei
... In the two hypotheses presented above (seasonal and functional variability), the four sites without microblade technology assigned to the Nenana complex (Walker Road component 1, Dry [r] ...
21
2010-Potter-APUA
... (Paleoarctic/Denali) tradition likely represented multiple language groups, some of whom expanded south into central North America through the ice-free corridor while others expanded so[r] ...
30
2010-Potter-etal-Bison
... The wood bison ( B.b. athabascae ) was the most recent variant to occur in Alaska, the Yukon and Northwest Territories and the plains bison ( B.b. bison ) is the most recent southern [r] ...
9
2010-Potter-etal-JAS
... In this paper, we present an assessment of pRIA in the identification of ancient proteins using faunal remains and stone tools from two Alaskan prehistoric sites, the Gerstle River and Cr[r] ...
9
2011-Potter-etal-Science
... Horizon boundaries within these upper forest soils (above the cultural components) range from clear to abrupt in distinctness with topography of the boundaries consistently wavy to sl[r] ...
19
2015-halffman-potter-etal
... Here we con- firm the presence of an anadromous salmon species, Oncorhynchus keta (chum salmon) through ancient DNA (aDNA) and stable isotope analyses of fish remains at the Upward Sun R[r] ...
12
2012-Potter-Reuther-American-Antiquity
... A site such as Gerstle River that has re- markable spatial resolution among hearth fea- tures and faunal clusters lends itself to studies concerning systematic vari[r] ...
28
2013-Potter-et-al
... Evidence from Mead, Swan Point, Broken Mammoth, Upward Sun River, and Gerstle River sites in the Tanana valley of central Alaska indicates that a com- plex adaptive strategy operated w[r] ...
23
2014-Potter-etal-pnas
... The burial and cremation are con- temporaneous, and differences in body orientation, treatment, and associated grave goods within a single feature and evidence for residential occupation[r] ...
30