Limb Development
Interplay between the molecular signals that control vertebrate limb development
... Conditional gene targeting of the type I BMP receptor (BmpR- IA) in mice and molecular gain and loss of function studies in the chick demonstrate that BMP signaling is necessary and sufficient to regulate both D-V ...
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Initiation of vertebrate limb development
... the limb buds (Crossley et ...induce limb development (see section ...endogenous limb inducers. FgfS expression in the limb ectoderm is detectable from stage 16 (Crossley et ...after ...
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The effect of perinatal brachial plexus lesion on upper limb development
... upper limb development [10-13]. Dif- ferences in upper limb length between healthy and af- fected limbs are more pronounced in total brachial plexus lesions than upper lesions ...whole limb ...
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Limb development: an international model for vertebrate pattern formation
... vertebrate limb development has been truly inter- ...on limb development was carried out in the United States particularly in the late 1940’s and continuing into the 1950’s and ...of ...
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Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development
... The function of TBX5 is primarily modulated by its interacting proteins, but as recent studies suggest it can also be modulated by posttranslational modifications such as acetylation (Lewandowski et al. 2014) and ...
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The role of the gene Msx-1 in limb development
... the limb in the progress zone, that are responsible for proximo-distal growth; second, the e?q)ression o f Msx-1 at the anterior margin o f the limb has been related to anterior positional identity and ...
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Sim1 and Sim2 expression during chick and mouse limb development
... Fig. 2. cSim1 expression during chick limb development. (A) In situ hybridisation to HH19 embryo with the cSim1 probe. (B,C) Consecutive transverse sections of HH19 embryos at the forelimb level hybridized ...
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Positional information in vertebrate limb development; an interview with Lewis Wolpert
... to development of the limb with Amata ...the limb the subject of his PhD and Julian Lewis joined the ...of limb development; Anthony Smith (another PhD student) and later Jonathan Slack ...
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Mechanobiology of embryonic limb development
... bone development, and perhaps this is due to the fact that the hypothesis that mechanical forces are essential for normal embryonic skeletal development is difficult to test and elaborate experimentally in ...
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The evolutionary transformation of phyllopodous to stenopodous limbs in the Branchiopoda (Crustacea) is there a common mechanism for early limb development in arthropods?
... early development of the trunk limbs in Leptodora kindtii and Cyclestheria hislopi is quite ...subdivided limb buds, six pairs of limb buds in ...long limb buds first form a lateral tip, then ...
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Genetic interaction of Gli3 and Alx4 during limb development
... nascent limb bud mesenchyme (Masuya et ...antero-posterior limb bud patterning (Wang et al., 2000). During progression of limb bud development, Alx4 becomes critical to suppress anterior ...
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The role of fibroblast growth factors in embryonic limb development
... of limb buds of ...the limb buds in MEM medium supplemented as described, the posterior thirds of the limb buds, which contain the polarizing region, were dissected and the mesenchyme was ...
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Anterior posterior differences in HoxD chromatin topology in limb development
... distal limb bud compared with distal anterior (P0.04) and also compared with the flank (P<0.0001), the proximal anterior (P0.02) and proximal posterior (P0.002) (Fig. 7B; supplementary material Table S7). ...
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Growing models of vertebrate limb development
... chick limb reaggregates in which the mesenchymal cells from the limb buds were disaggregated into single cells and then placed inside a normal ectodermal jacket (Pautou, 1973) (reviewed by Wolpert, ...
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Cell Signalling in Limb Development and Hindbrain Segmentation
... The analysis of the way the receptor operates in the hindbrain, the progress zone and during tendon development may help to define the function of Cek-8, f^A-receptor activation requires binding by ...
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Wnt signalling during limb development
... myogenic development such as migration and cell morphology. In the limb bud, N-cadherin is essential for myogenic migration and, during chondrogenesis, Wnt7a has been shown to maintain the expression of ...
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Signals regulating muscle formation in the limb during embryonic development
... mouse limb (Ontell et ...chick limb. This sequential activation during limb development reflects the hierar- chy among MRF family members defined by gene ...
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Limb patterning genes and heterochronic development of the emu wing bud
... fore- limb development in the emu, key patterning genes were examined during ...heterochronic development relative to that in chicken, as the developing forelimb bud is small in size and fails to ...
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SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis
... to limb morphogenesis were skeletal myogenesis, skeletogenesis and vascular network ...early limb development, such as genes for HOX transcription factors and morphogens (Table ...
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Transcriptional heterochrony in talpid mole autopods
... specializations in the autopodial skeleton, it is synchron- ous, we hypothesize that this transcriptional hetero- chrony in limbs of the talpid mole accounts for the pattern heterochrony in chondral limb ...
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