Multiple mutants in the nitrate binding site
Mapping of Vps21 and HOPS Binding Sites in Vps8 and Effect of Binding Site Mutants on Endocytic Trafficking
... Vps21 binding only had a modest effect on Ste6 trafficking and CPY sorting, while dele- tions that abolish interaction with the class C/HOPS core com- plex caused severe trafficking ...
9
Infectivity Studies of Influenza Virus Hemagglutinin Receptor Binding Site Mutants in Mice
... its binding properties, that mutations located at various positions in and around the HA receptor binding site can be selected during replication of this mutant in the mouse respiratory tract, and ...
5
Analysis of site-directed mutants of the FX-binding region of photosystem I and second site revertants in Chlamydomonas reinhardtii
... on the "borderline" o f being com petent in photosynthesis. O ne o f the factors w hich determ ines the rate o f electron transfer is the distance betw een carriers. A \ has not been exactly located in the current 4Â ...
153
Replication and Pathogenicity of Primer Binding Site Mutants of SL3-3 Murine Leukemia Viruses
... PBS mutants were found to revert to tRNA Pro utilization, PBS-modified HIV-1 (11, 21, 45) and avian leukosis virus (47), analyzed by extended growth in cell culture, were found to eventually revert to the PBS ...
6
Using Antibodies and Mutants To Localize the Presumptive gH/gL Binding Site on Herpes Simplex Virus gD
... Perhaps the viral population for these mutants became extinct before an escape mutant could emerge. Although both MC2 and MC5 block a step that occurs after gD binds its receptor, our data show that they bind in ...
15
MONKEY: identifying conserved transcription factor binding sites in multiple alignments using a binding site specific evolutionary model
... constrained binding sites should improve until we are no longer able to reliably assign orthology based on sequence ...of multiple closely related species can be used to span the same evolutionary distances ...
15
Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression.
... with site-directed mutagenesis using Quick Change XL (Agilent, Santa Clara, ...and site- directed mutagenesis changes were Sanger-sequenced using primers detailed in Supplementary Table ...
9
Second-site proviral enhancer alterations in lymphomas induced by enhancer mutants of SL3-3 murine leukemia virus: negative effect of nuclear factor 1 binding site.
... The fact that we frequently find variations in the number of repeats but only rarely see the NF1 site deletions indicates that the two types of alterations do not occur with the same fre- quency. The deletions ...
11
Ahr Transcription Factor Binding Site
... peptide binding specificity. Binding Sites Influence AHR Ligand-Dependent Gene ...dre site will be performed. Ahr transcriptional factor binding sites can alter transcription factors next step ...
15
Multiple Heparan Sulfate Binding Site Engagements Are Required for the Infectious Entry of Human Papillomavirus Type 16
... primary binding and allowing second- ary receptor engagements in the absence of MMP ...The site 3 residues could also be directly involved in mediating an interaction with non-HSPG receptors on the cell ...
12
Potent Rescue of Human Immunodeficiency Virus Type 1 Late Domain Mutants by ALIX/AIP1 Depends on Its CHMP4 Binding Site
... Tsg101 binding site ...p6 mutants to replicate in T-cell lines, we noticed that Jurkat cells are partially permissive for viruses that have only the Tsg101 or only the ALIX binding site ...
9
Calorimetric scrutiny of lipid binding by sticholysin II toxin mutants
... POC-binding site described by X-ray crystallography 7 ...POC-binding site was proposed to be a phospholipid-binding region 7 ...membrane binding 7 ...
32
Protocol for Genome Editing to Produce Multiple Mutants in Wheat
... genome-edited multiple-recessive mutants in wheat, the target se- quences must have a protospacer adjacent motif (PAM) for Cas9 nuclease and a re- striction site for verifying the ...
20
Functional analysis of the adenovirus type 5 DNA-binding protein: site-directed mutants which are defective for adeno-associated virus helper activity.
... For these experi- ments, we used AAV-infected cells transfected with plas- mids containing the E4 gene, the VA RNA genes, Ela, and the appropriate mutant DBP gene under the control of th[r] ...
9
Multiple high affinity binding sites for
... 5-HT binding sites in the Arctic charr brain, all showing high affinities for the endogenous ligand but differing affinities for the synthetic ligands, best illustrated by the three-site model found with ...
7
CiteSeerX — Binding Site on the Light Neurofilament Subunit
... The properties of the NFL-TBS.40-63 peptide are affected by their phosphorylation status Neurofilaments are known phospho-proteins, and multiple aspects of their biology, including assembly and axonal transport, ...
12
Identification of an allosteric binding site for RORγt inhibition.
... Helix 12 repositions to generate a novel binding pocket. Literature suggests that the RORs feature ligand-independent transcription, with their LBDs partially in a conformation promoting coactivator binding ...
10
MicroRNA-binding site polymorphisms in hematological malignancies
... The second polymorphism found to affect survival of patients with multiple myeloma was rs11077 in XPO5. This miRSNP, apart from its potential impact on expres- sion of XPO5, can also affect the whole miRNA-ome of ...
6
Dynamics of transcription factor binding site evolution
... Sequence-specific binding of transcription factors to the regulatory regions on the DNA is a key regulatory mechanism that determines gene expression and hence heritable phenotypic ...factor binding sites ...
28
Transcription Factor Binding Site Prediction Online
... factor binding site prediction online primer designing a special ...tf binding from work, with one can model to publications office is equivalent positions ...factor binding site ...
10