Mutation–selection balance
Pleiotropic Model of Maintenance of Quantitative Genetic Variation at Mutation-Selection Balance
... at mutation-selection balance is ...stabilizing selection (V s ) and the genetic variance maintained in segregating populations (V G ) were ...
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Mutation-Selection Balance, Dominance and the Maintenance of Sex
... the mutation rate per genome must be of order one, and, second, multiple mutations within a genome must act with positive epistasis, that is, two or more mutations of different genes must be more harmful together ...
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Influence of Dominance, Leptokurtosis and Pleiotropy of Deleterious Mutations on Quantitative Genetic Variation at Mutation-Selection Balance
... stabilizing selection have that inclusion of more realistically variable dominance abundant variation (Falconer and Mackay 1996; Bu ¨ r- of mutations strengthens the previous joint-effect model ger ...that ...
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Disequilibrium in two-locus mutation-selection balance models.
... FELDMAN, CHRISTIANSEN, and BROOKS (1980) show that if disequilibrium generated by mutation selection balance is positive, modifiers which increase recombination rate will [r] ...
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Dynamic Mutation–Selection Balance as an Evolutionary Attractor
... purifying selection. Yet in finite asexual populations, purifying selection cannot completely prevent the accumulation of deleterious mutations due to Muller’s ratchet: once lost by stochastic drift, the ...
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EFFECTS OF PLEIOTROPY ON PREDICTIONS CONCERNING MUTATION-SELECTION BALANCE FOR POLYGENIC TRAITS
... T h e house-of-cards prediction that increasing intensity of pleiotropic selection drives the equilibrium genetic variance downward depends critically on the assumption that [r] ...
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MUTATION-SELECTION BALANCE IN MULTI-LOCUS SYSTEMS. I. DUPLICATE GENE ACTION
... Similarly, an extended model is more appropriate for loci that have undergone multiple tandem duplications over time, such as has occurred i n the globin-like clusters.. For example,[r] ...
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Joint Effects of Pleiotropic Selection and Stabilizing Selection on the Maintenance of Quantitative Genetic Variation at Mutation-Selection Balance
... The pure pleiotropic model (Keightley and Hill 1990; Kondrashov and Turelli 1992; Zhang et al. 2002) can account for substantial quantitative genetic variation, but the apparent stabilizing selection of strength V ...
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Mutation-Selection Balance Under Genomic Imprinting at an Autosomal Locus
... CER and WILLIAMS ( 1995), to examine the equilibrium frequency of a deleterious autosomal mutant at a locus subject to imprinting. I first look at the simplest case of c[r] ...
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Linkage and the maintenance of heritable variation by mutation-selection balance.
... two-locus models. Cambridge University Press. FELDMAN, 1970 Linkage and selection: two locus symmetric viability model. HILL, 1988 Quantitative genetic variability maintained b[r] ...
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Multivariate mutation-selection balance with constrained pleiotropic effects.
... In terms of quantitative genetic theory this means that the possi- ble pleiotropic effects of quantitative genetic variation are most often not changed by mutations at [r] ...
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Mutation-Selection Balance at a Modifier-of-Imprinting Locus
... The models predict the stable equilibrium frequencies of the mutant modifier and functionally diploid individuals in a large population in terms of up to four parameters: the m[r] ...
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Mutation-selection balance and metabolic control theory.
... Changes in activity of an enzyme will affect the immediately flanking metabolite pools more than pools more distant in the pathway (as is the case for the human inborn e[r] ...
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The Population Genetics of Synthetic Lethals
... Unbalanced mutation rates: The influence of unbal- anced mutation rates in complete epistasis has been solved by Christiansen and Frydenberg (1977), who found that populations will evolve to an equilibrium ...
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Background Selection in Partially Selfing Populations
... background selection on neutral diversity in randomly mating populations, using different approaches (Hudson and Kaplan 1995; Nordborg et ...at mutation–selection balance reduces the expected ...
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Conditions for Positive and Negative Correlations Between Fitness and Heterozygosity in Equilibrium Populations
... the mutation rate at a locus? Our knowledge about the conclusions are the ...a mutation-selection balance has been 11 can be reduced to Equation 10 for the biallelic situa- approximately ...
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Selection on metabolic pathway function in the presence of mutation-selection-drift balance leads to rate-limiting steps that are not evolutionarily stable
... of mutation-selection balance as a limit to pathway control will disappear with a larger effective population ...with selection just on metabolic ...that mutation-selection bal- ...
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THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. XVIII. CLINAL AND UNIFORM GENETIC VARIATION OVER POPULATIONS
... R States populations maintain a greater amount of genetic variability of viability that can be explained by a mutation-selection balance (MUKAI et al. T h e estimat[r] ...
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Asexual but Not Clonal: Evolutionary Processes in Automictic Populations
... size, mutation–selection balance, selection with overdominance, the spread of bene fi cial mutations, and selection on crossover ...
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Redistribution of Gene Frequency and Changes of Genetic Variation Following a Bottleneck in Population Size
... of selection and mutation generate different predictions of frequency ...at mutation-selection balance passes through a rapid bottleneck in size, the frequency distribution of genes is ...
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