mutations in the hypervariable region 1.
Hypervariable Region 1 Deletion and Required Adaptive Envelope Mutations Confer Decreased Dependency on Scavenger Receptor Class B Type I and Low-Density Lipoprotein Receptor for Hepatitis C Virus
... for 1 h at 37°C in four replicates with anti-ApoE MAb (1D7) in the indicated dilution series, along with four replicates with 50 g/ml of control antibody (mouse IgG1) and 6 replicates with medium ...
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Hypervariable Region 1 Differentially Impacts Viability of Hepatitis C Virus Strains of Genotypes 1 to 6 and Impairs Virus Neutralization
... Serum from patient H was shown to prevent H77C (geno- type 1a) infection in vivo (31) and exhibited cross-genotype neutralization in vitro (20, 29). Therefore, we chose H06 serum to investigate susceptibility to ...
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Genetic Heterogeneity of Hypervariable Region 1 of the Hepatitis C Virus (HCV) Genome and Sensitivity of HCV to Alpha Interferon Therapy
... genotype 1 and genotype 2 to IFN-␣ ...HVR-1 region in HCV-1b- and HCV-2c-infected pa- tients have also been reported ...of mutations in the HVR-1 region compared to the same ...
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Vertical Transmission of the Hepatitis C Virus to Infants of Anti Human Immunodeficiency Virus Negative Mothers: Molecular Evolution of Hypervariable Region 1 in Prenatal and Perinatal or Postnatal Infections
... E1 region in a previous study, where nucleotide variability was considerably greater at the time of birth than 6 months after birth ...a region found within the E2 envelope protein which was shown to be a ...
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Basic Residues in Hypervariable Region 1 of Hepatitis C Virus Envelope Glycoprotein E2 Contribute to Virus Entry
... The N terminus of hepatitis C virus (HCV) envelope glycoprotein E2 contains a hypervariable region (HVR1) which has been proposed to play a role in viral entry. Despite strong amino acid variability, HVR1 ...
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Production and Characterization of Monoclonal Antibodies Specific for a Conserved Epitope within Hepatitis C Virus Hypervariable Region 1
... In contrast, when the analysis was restricted to the five C- terminus amino acids, some features emerged. Both MAbs appear to recognize a limited repertoire of sequences in posi- tions 23 to 26 containing G–P/A–R/Q–Q in ...
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Evolution of Hepatitis C Virus Quasispecies in Hypervariable Region 1 and the Putative Interferon Sensitivity-Determining Region during Interferon Therapy and Natural Infection
... genotype 1, including four nonresponders, four responders who relapsed after therapy, and one responder who experienced a breakthrough of viremia during ...variable region 1 (HVR1) and the putative ...
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Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus
... Hypervariable region 1 (HVR1) (amino acids [aa] 384 to 410) on the E2 glycoprotein of hepatitis C virus contributes to persistent infection by evolving escape mutations that attenuate binding ...
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Hypervariable Region 1 Sequence Stability during Hepatitis C Virus Replication in Chimpanzees
... variable region referred to as hypervariable region 1 ...random mutations in a region with relatively little functional ...nonsynonymous mutations indicate selection ...
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Characterization of Hepatitis C Virus genotype 3a Hypervariable region 1 in patients achieved rapid virological response to alpha interferon and Ribavirin Combination therapy
... this region is imperative for understanding the role of envel- ope gene specifically HVR1 in virus interaction to target cells and its persistence which will effect the outcome of ...significant mutations ...
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Analysis of Hepatitis C Virus Hypervariable Region 1 Sequence from Cryoglobulinemic Patients and Associated Controls
... HCV hypervariable region 1 (HVR1) may be associated with ...of mutations, principal component analysis, and phylogenetic analysis failed to show statistically significant differences between ...
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Evolution of Hypervariable Region 1 of Hepatitis C Virus in Primary Infection
... The hypervariable region 1 (HVR-1) of the putative envelope encoding E2 region of hepatitis C virus (HCV) RNA was analyzed in sequential samples from three patients with acute type C ...
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Epitope mapping of antibodies directed against hypervariable region 1 in acute self-limiting and chronic infections due to hepatitis C virus.
... have mutations in B- and T-cell epitopes (28, ...a region of about 27 amino acids, termed hypervariable region 1 (HVR1), which is located at the N terminus of envelope pro- tein E2 (13, ...
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Sequence evolution of the hypervariable region in the putative envelope region E2/NS1 of hepatitis C virus is correlated with specific humoral immune responses.
... the hypervariable region 1 (HVR1) in the N terminus of E2/NS1 of hepatitis C virus (HCV) was studied retrospectively in six chimpanzees inoculated with the same genotype 1b strain, containing a ...
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The Hypervariable HIV-1 Capsid Protein Residues Comprise HLA-Driven CD8+ T-Cell Escape Mutations and Covarying HLA-Independent Polymorphisms
... pensatory mutations, we identified “high-variability” positions in the p24 NTD by analyzing amino acid sequences using the Los Alamos National Laboratory (LANL) database Shan- non entropy tool ...(loop 1, ...
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The Hypervariable Region of Meningococcal Major Pilin PilE Controls the Host Cell Response via Antigenic Variation
... some mutations in the pilin-related machinery could be restored in a pilus retraction-deficient background (PilT ⫺ ) (33), we tested the ability of a PilT ⫺ PilV ⫺ strain to signal to endothelial ...Fig. 1, ...
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Single amino acid substitution in constant region 1 or 4 of gp120 causes the phenotype of a human immunodeficiency virus type 1 variant with mutations in hypervariable regions 1 and 2 to revert.
... The second major cysteine loop of gp120 contains 5 to 11 consensus N-linked glycosylation sites (Asn-Xaa-Ser/Thr), which is disproportionately higher than the number of such sites found in most other regions of gp120 ...
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Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus.
... Furthermore, analysis of the kinetics of the appearance of antibodies in two patients with chronic hepatitis, with whom successive alterations of amino acids of HVR1 have been observed, [r] ...
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Two laboratory collaborative study on identification of mycobacteria: molecular versus phenotypic methods
... (i) The first is a group of species which exhibit slow growth and yet show the molecular signature of rapidly growing spe- cies, i.e., a short helix 18. These species have a nucleic acid sequence in hypervariable ...
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Combination of 16S rRNA variable regions provides a detailed analysis of bacterial community dynamics in the lungs of cystic fibrosis patients
... per cent stringency, which resulted in a very small database of organisms and their corresponding frag- ment lengths. Many CF pathogens, including P. aer- uginosa, were not present at this high stringency. By lowering ...
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